ENSG00000039319

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338008 ENSG00000039319 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE16 protein_coding protein_coding 8.938397 0.8448021 16.07903 0.0526255 1.222115 4.234343 0.98981841 0.367149099 1.97980298 0.068785897 0.20960617 2.399419 0.22433750 0.427366667 0.123933333 -0.30343333 3.439264e-05 5.57549e-09 FALSE TRUE
ENST00000505560 ENSG00000039319 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE16 protein_coding protein_coding 8.938397 0.8448021 16.07903 0.0526255 1.222115 4.234343 1.31774562 0.035377962 1.94835278 0.035377962 0.14595157 5.431505 0.12642083 0.039533333 0.121500000 0.08196667 8.708880e-02 5.57549e-09 FALSE TRUE
ENST00000510995 ENSG00000039319 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE16 protein_coding retained_intron 8.938397 0.8448021 16.07903 0.0526255 1.222115 4.234343 0.82398609 0.009726577 1.37875137 0.009726577 0.37029030 6.137504 0.05481250 0.010800000 0.083333333 0.07253333 1.132679e-01 5.57549e-09 FALSE TRUE
ENST00000511050 ENSG00000039319 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE16 protein_coding processed_transcript 8.938397 0.8448021 16.07903 0.0526255 1.222115 4.234343 1.94219916 0.000000000 3.55199879 0.000000000 0.46392955 8.476543 0.13408333 0.000000000 0.218900000 0.21890000 1.160812e-06 5.57549e-09 FALSE FALSE
ENST00000511829 ENSG00000039319 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE16 protein_coding retained_intron 8.938397 0.8448021 16.07903 0.0526255 1.222115 4.234343 0.09838897 0.204145540 0.06324932 0.107752630 0.03404720 -1.547704 0.08575833 0.256233333 0.004033333 -0.25220000 3.455877e-02 5.57549e-09 FALSE TRUE
ENST00000512442 ENSG00000039319 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE16 protein_coding processed_transcript 8.938397 0.8448021 16.07903 0.0526255 1.222115 4.234343 0.08697562 0.188930014 0.07908255 0.055217637 0.04577154 -1.159046 0.07236250 0.219100000 0.005366667 -0.21373333 3.779990e-06 5.57549e-09   FALSE
ENST00000512558 ENSG00000039319 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFYVE16 protein_coding retained_intron 8.938397 0.8448021 16.07903 0.0526255 1.222115 4.234343 2.95035105 0.005222413 5.79691898 0.005222413 0.17545746 8.575432 0.20935833 0.007066667 0.363766667 0.35670000 5.575490e-09 5.57549e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000039319 E001 2.9818534 0.0948013801 7.103354e-01 8.075353e-01 5 80407622 80407881 260 + 0.402 0.365 -0.208
ENSG00000039319 E002 0.7728905 0.0144328732 3.398541e-01 4.837799e-01 5 80408013 80408023 11 + 0.121 0.365 2.037
ENSG00000039319 E003 3.2881185 0.0045556685 7.792349e-01 8.580230e-01 5 80408024 80408054 31 + 0.416 0.561 0.714
ENSG00000039319 E004 4.4769472 0.0035341718 8.664979e-01 9.180623e-01 5 80408055 80408063 9 + 0.512 0.561 0.229
ENSG00000039319 E005 7.8876518 0.0022228588 2.633026e-01 4.011829e-01 5 80408064 80408075 12 + 0.707 0.561 -0.636
ENSG00000039319 E006 12.5510964 0.0013564540 3.166486e-01 4.594398e-01 5 80408076 80408082 7 + 0.871 0.797 -0.285
ENSG00000039319 E007 18.6552715 0.0011268279 1.085296e-01 2.033795e-01 5 80408083 80408114 32 + 1.027 0.880 -0.548
ENSG00000039319 E008 23.5646164 0.0008024277 5.423918e-02 1.166670e-01 5 80408115 80408153 39 + 1.121 0.950 -0.626
ENSG00000039319 E009 2.3509463 0.0064929847 8.123594e-08 8.397395e-07 5 80409692 80410340 649 + 0.147 1.109 4.885
ENSG00000039319 E010 0.9619687 0.0125956472 5.567989e-03 1.747028e-02 5 80411646 80411773 128 + 0.094 0.695 4.036
ENSG00000039319 E011 6.8385714 0.0024127078 1.125288e-01 2.092362e-01 5 80427492 80427545 54 + 0.664 0.365 -1.455
ENSG00000039319 E012 36.5573356 0.0016398523 1.875310e-03 6.839518e-03 5 80434109 80434217 109 + 1.305 1.010 -1.057
ENSG00000039319 E013 0.0000000       5 80435762 80435854 93 +      
ENSG00000039319 E014 366.9603591 0.0005586873 1.861249e-26 2.301620e-24 5 80436756 80439007 2252 + 2.286 1.958 -1.101
ENSG00000039319 E015 49.9666042 0.0005051154 2.881460e-01 4.286883e-01 5 80439936 80440032 97 + 1.419 1.437 0.064
ENSG00000039319 E016 3.3332716 0.0046963684 5.817903e-01 7.062768e-01 5 80440033 80440376 344 + 0.429 0.365 -0.355
ENSG00000039319 E017 1.0308569 0.0221632194 8.924048e-01 9.352456e-01 5 80441173 80441249 77 + 0.194 0.000 -10.339
ENSG00000039319 E018 1.1993242 0.2685202595 8.391369e-01 8.994730e-01 5 80443049 80443122 74 + 0.217 0.000 -9.729
ENSG00000039319 E019 36.0535086 0.0005893301 1.995157e-01 3.256270e-01 5 80443123 80443151 29 + 1.286 1.259 -0.096
ENSG00000039319 E020 63.5520032 0.0006874311 3.883489e-01 5.324350e-01 5 80443152 80443284 133 + 1.516 1.564 0.162
ENSG00000039319 E021 0.7448917 0.0584063290 1.000000e+00 1.000000e+00 5 80443794 80443920 127 + 0.147 0.000 -9.591
ENSG00000039319 E022 0.0000000       5 80445261 80445262 2 +      
ENSG00000039319 E023 63.2534839 0.0003678274 1.172392e-02 3.287408e-02 5 80445263 80445405 143 + 1.524 1.416 -0.374
ENSG00000039319 E024 81.3511493 0.0009445370 9.124795e-05 4.808793e-04 5 80448026 80448282 257 + 1.635 1.416 -0.751
ENSG00000039319 E025 44.9954085 0.0004923692 1.344866e-01 2.403955e-01 5 80448283 80448404 122 + 1.378 1.344 -0.118
ENSG00000039319 E026 60.1347660 0.0004163147 5.797459e-01 7.045786e-01 5 80449591 80449713 123 + 1.491 1.563 0.249
ENSG00000039319 E027 77.6336935 0.0003153497 1.314117e-01 2.361199e-01 5 80450431 80450586 156 + 1.603 1.608 0.016
ENSG00000039319 E028 76.6311160 0.0003560678 1.019589e-02 2.924775e-02 5 80451485 80451709 225 + 1.603 1.514 -0.306
ENSG00000039319 E029 1.9273777 0.0625756307 3.694683e-01 5.138807e-01 5 80451710 80452460 751 + 0.311 0.000 -10.852
ENSG00000039319 E030 3.8826406 0.0040230902 4.459244e-01 5.874760e-01 5 80453989 80455691 1703 + 0.478 0.365 -0.607
ENSG00000039319 E031 47.9307613 0.0005009045 1.961736e-01 3.214395e-01 5 80455692 80455774 83 + 1.401 1.393 -0.027
ENSG00000039319 E032 6.0699473 0.0026931317 2.218958e-02 5.606345e-02 5 80455775 80456460 686 + 0.633 0.000 -12.625
ENSG00000039319 E033 51.5213295 0.0004962007 4.488334e-01 5.900732e-01 5 80456461 80456565 105 + 1.428 1.477 0.170
ENSG00000039319 E034 58.0019771 0.0004597309 9.665609e-01 9.830412e-01 5 80456945 80457092 148 + 1.472 1.594 0.415
ENSG00000039319 E035 41.0566895 0.0004944765 8.836915e-01 9.296057e-01 5 80459414 80459438 25 + 1.327 1.458 0.452
ENSG00000039319 E036 52.2342159 0.0009401931 3.039749e-01 4.459521e-01 5 80459439 80459494 56 + 1.420 1.622 0.692
ENSG00000039319 E037 78.0687820 0.0013128043 3.768329e-01 5.211472e-01 5 80472761 80472923 163 + 1.591 1.771 0.611
ENSG00000039319 E038 52.0551866 0.0004588929 1.396726e-01 2.475679e-01 5 80473754 80473859 106 + 1.413 1.649 0.805
ENSG00000039319 E039 58.0526570 0.0008809021 3.562110e-02 8.284811e-02 5 80474663 80474830 168 + 1.457 1.730 0.933
ENSG00000039319 E040 235.9394407 0.0386984035 1.242005e-09 1.807175e-08 5 80477219 80483379 6161 + 1.995 2.616 2.075