ENSG00000038532

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261657 ENSG00000038532 HEK293_OSMI2_2hA HEK293_TMG_2hB CLEC16A protein_coding protein_coding 9.291369 12.0649 6.827184 0.4313438 0.2057172 -0.8205367 1.517900 3.027136 0.1393741 0.5019675 0.03647122 -4.3457093 0.13794583 0.2521667 0.02023333 -0.2319333 1.469402e-08 1.469402e-08 FALSE FALSE
MSTRG.12041.1 ENSG00000038532 HEK293_OSMI2_2hA HEK293_TMG_2hB CLEC16A protein_coding   9.291369 12.0649 6.827184 0.4313438 0.2057172 -0.8205367 4.796505 4.831144 4.2692719 0.7571280 0.19809215 -0.1779827 0.54022500 0.3982000 0.62496667 0.2267667 1.092763e-02 1.469402e-08 FALSE TRUE
MSTRG.12041.2 ENSG00000038532 HEK293_OSMI2_2hA HEK293_TMG_2hB CLEC16A protein_coding   9.291369 12.0649 6.827184 0.4313438 0.2057172 -0.8205367 1.192600 0.000000 1.1975599 0.0000000 0.59899439 6.9159509 0.13834167 0.0000000 0.17796667 0.1779667 1.378618e-01 1.469402e-08 FALSE TRUE
MSTRG.12041.4 ENSG00000038532 HEK293_OSMI2_2hA HEK293_TMG_2hB CLEC16A protein_coding   9.291369 12.0649 6.827184 0.4313438 0.2057172 -0.8205367 1.047289 3.421607 0.5414106 0.1052528 0.38144236 -2.6376854 0.09994167 0.2837667 0.07900000 -0.2047667 2.284453e-01 1.469402e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000038532 E001 0.0000000       16 10944562 10944563 2 +      
ENSG00000038532 E002 1.6359856 0.3984855482 9.158596e-02 1.776096e-01 16 10944564 10944579 16 + 0.617 0.195 -2.468
ENSG00000038532 E003 3.6749079 0.0219854693 2.370116e-04 1.120735e-03 16 10944580 10944580 1 + 0.905 0.373 -2.374
ENSG00000038532 E004 40.6726982 0.0038823792 7.258657e-10 1.104878e-08 16 10944581 10944797 217 + 1.778 1.461 -1.082
ENSG00000038532 E005 52.8527227 0.0059897614 2.229156e-08 2.575670e-07 16 10957782 10957910 129 + 1.870 1.596 -0.928
ENSG00000038532 E006 54.7137224 0.0023746413 1.215046e-05 7.915096e-05 16 10962455 10962588 134 + 1.827 1.658 -0.570
ENSG00000038532 E007 65.3392272 0.0004176563 1.338362e-05 8.632619e-05 16 10969161 10969309 149 + 1.881 1.748 -0.449
ENSG00000038532 E008 57.4664575 0.0013316699 1.122492e-05 7.372004e-05 16 10971125 10971230 106 + 1.839 1.683 -0.528
ENSG00000038532 E009 0.0000000       16 10972481 10972553 73 +      
ENSG00000038532 E010 0.0000000       16 10972554 10972559 6 +      
ENSG00000038532 E011 65.5952227 0.0005020735 1.202819e-07 1.203562e-06 16 10972938 10973061 124 + 1.905 1.731 -0.587
ENSG00000038532 E012 75.5617583 0.0044224766 2.369057e-04 1.120319e-03 16 10977225 10977399 175 + 1.939 1.812 -0.429
ENSG00000038532 E013 41.8534929 0.0063381015 1.134602e-02 3.199188e-02 16 10979329 10979382 54 + 1.673 1.566 -0.365
ENSG00000038532 E014 65.7657168 0.0093338773 3.620968e-01 5.064949e-01 16 10982878 10982991 114 + 1.803 1.809 0.021
ENSG00000038532 E015 86.5087939 0.0062717122 3.595448e-01 5.038776e-01 16 11003074 11003257 184 + 1.916 1.929 0.047
ENSG00000038532 E016 28.1715724 0.0007115230 1.673370e-01 2.847294e-01 16 11003258 11003305 48 + 1.470 1.436 -0.120
ENSG00000038532 E017 57.5143235 0.0004612513 1.039080e-01 1.964597e-01 16 11020193 11020325 133 + 1.761 1.742 -0.065
ENSG00000038532 E018 0.1515154 0.0433366372 3.017219e-01   16 11024153 11024261 109 + 0.143 0.000 -12.545
ENSG00000038532 E019 0.0000000       16 11024473 11024479 7 +      
ENSG00000038532 E020 0.1482932 0.0421368243 7.659233e-01   16 11024480 11024507 28 + 0.000 0.104 11.284
ENSG00000038532 E021 0.1482932 0.0421368243 7.659233e-01   16 11024508 11024526 19 + 0.000 0.104 11.284
ENSG00000038532 E022 0.1482932 0.0421368243 7.659233e-01   16 11024527 11024571 45 + 0.000 0.104 11.284
ENSG00000038532 E023 0.2965864 0.2755169159 4.532776e-01   16 11024818 11024820 3 + 0.000 0.184 11.397
ENSG00000038532 E024 41.1044983 0.0005516253 1.265162e-01 2.292996e-01 16 11024821 11024866 46 + 1.624 1.596 -0.094
ENSG00000038532 E025 36.8674771 0.0006139077 6.140697e-01 7.326444e-01 16 11024867 11024921 55 + 1.544 1.572 0.094
ENSG00000038532 E026 0.3686942 0.0311724308 7.165968e-01 8.122163e-01 16 11036047 11036092 46 + 0.143 0.104 -0.526
ENSG00000038532 E027 51.7341427 0.0004426614 4.783562e-01 6.167776e-01 16 11039754 11039876 123 + 1.691 1.713 0.075
ENSG00000038532 E028 0.3697384 0.0251137735 3.716134e-01 5.160799e-01 16 11039877 11042253 2377 + 0.000 0.188 12.450
ENSG00000038532 E029 52.5045792 0.0004773918 4.668838e-01 6.064099e-01 16 11042254 11042363 110 + 1.647 1.742 0.320
ENSG00000038532 E030 40.8689366 0.0005525015 7.209374e-01 8.154677e-01 16 11044028 11044072 45 + 1.577 1.614 0.126
ENSG00000038532 E031 0.9629111 0.3401444598 1.189789e-01 2.184806e-01 16 11044073 11044105 33 + 0.000 0.407 12.832
ENSG00000038532 E032 0.0000000       16 11044106 11044222 117 +      
ENSG00000038532 E033 42.5677156 0.0012344915 5.082737e-01 6.437271e-01 16 11047292 11047342 51 + 1.603 1.623 0.067
ENSG00000038532 E034 1.6606579 0.0205937670 7.594890e-03 2.275908e-02 16 11047343 11048318 976 + 0.000 0.537 14.596
ENSG00000038532 E035 0.7761102 0.0407774736 5.985169e-01 7.200973e-01 16 11048319 11048518 200 + 0.143 0.260 1.064
ENSG00000038532 E036 65.2663476 0.0058137947 2.971619e-01 4.384662e-01 16 11051513 11051641 129 + 1.803 1.802 -0.004
ENSG00000038532 E037 64.6041350 0.0005448983 2.488605e-01 3.845972e-01 16 11060902 11061022 121 + 1.792 1.798 0.019
ENSG00000038532 E038 82.0694483 0.0003166126 6.192864e-01 7.367525e-01 16 11120615 11120766 152 + 1.874 1.912 0.128
ENSG00000038532 E039 29.5967299 0.0006740174 3.396224e-01 4.835517e-01 16 11123742 11123742 1 + 1.470 1.465 -0.019
ENSG00000038532 E040 72.8971016 0.0003552983 7.411377e-01 8.304140e-01 16 11123743 11123894 152 + 1.821 1.865 0.148
ENSG00000038532 E041 30.7768801 0.0130778775 6.822131e-01 7.856899e-01 16 11123895 11123899 5 + 1.428 1.520 0.317
ENSG00000038532 E042 41.6787489 0.0028361823 4.898098e-01 6.272001e-01 16 11123900 11123946 47 + 1.549 1.649 0.342
ENSG00000038532 E043 41.4011394 0.0005624438 6.857280e-01 7.883719e-01 16 11125979 11126009 31 + 1.559 1.639 0.273
ENSG00000038532 E044 63.6256316 0.0005039607 4.772006e-01 6.158074e-01 16 11126010 11126146 137 + 1.731 1.822 0.307
ENSG00000038532 E045 3.2637956 0.0446305210 4.136604e-01 5.570962e-01 16 11126147 11126787 641 + 0.470 0.660 0.871
ENSG00000038532 E046 0.1451727 0.0432392285 3.021658e-01   16 11136069 11136283 215 + 0.143 0.000 -12.546
ENSG00000038532 E047 2.6120452 0.0068732646 5.969617e-01 7.188151e-01 16 11149886 11150317 432 + 0.471 0.599 0.606
ENSG00000038532 E048 0.0000000       16 11156574 11156682 109 +      
ENSG00000038532 E049 0.1482932 0.0421368243 7.659233e-01   16 11157077 11157233 157 + 0.000 0.104 11.284
ENSG00000038532 E050 61.0302700 0.0021062557 4.589697e-01 5.992078e-01 16 11166388 11166552 165 + 1.708 1.804 0.326
ENSG00000038532 E051 5.5813570 0.0255458025 5.032229e-01 6.391954e-01 16 11174154 11174277 124 + 0.691 0.845 0.619
ENSG00000038532 E052 32.1538507 0.0101568419 7.561042e-01 8.412619e-01 16 11178335 11178384 50 + 1.476 1.511 0.120
ENSG00000038532 E053 99.1922335 0.0009599629 7.363609e-02 1.493543e-01 16 11178385 11178896 512 + 1.986 1.976 -0.033
ENSG00000038532 E054 878.5682082 0.0051030958 3.649324e-12 8.159488e-11 16 11178897 11182186 3290 + 2.755 3.002 0.822