ENSG00000038427

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265077 ENSG00000038427 HEK293_OSMI2_2hA HEK293_TMG_2hB VCAN protein_coding protein_coding 5.295164 5.954355 6.817313 0.6312842 0.2631008 0.1949518 0.3806777 0.1020566 0.96287230 0.04969410 0.009790855 3.118023 0.06495833 0.01690000 0.14156667 0.12466667 1.492814e-08 1.492814e-08 FALSE TRUE
ENST00000343200 ENSG00000038427 HEK293_OSMI2_2hA HEK293_TMG_2hB VCAN protein_coding protein_coding 5.295164 5.954355 6.817313 0.6312842 0.2631008 0.1949518 2.6359934 1.6323418 3.67547950 0.30430120 0.089812414 1.166098 0.49238333 0.27363333 0.54110000 0.26746667 8.188104e-04 1.492814e-08 FALSE TRUE
ENST00000503923 ENSG00000038427 HEK293_OSMI2_2hA HEK293_TMG_2hB VCAN protein_coding retained_intron 5.295164 5.954355 6.817313 0.6312842 0.2631008 0.1949518 0.4957440 0.2521222 1.10785918 0.12932625 0.191660276 2.092427 0.08800000 0.03840000 0.16090000 0.12250000 1.804222e-01 1.492814e-08   FALSE
ENST00000505615 ENSG00000038427 HEK293_OSMI2_2hA HEK293_TMG_2hB VCAN protein_coding retained_intron 5.295164 5.954355 6.817313 0.6312842 0.2631008 0.1949518 1.5326315 3.4354708 0.85028493 0.06208525 0.115774623 -2.001815 0.30045833 0.59136667 0.12380000 -0.46756667 5.026813e-08 1.492814e-08 FALSE TRUE
ENST00000507162 ENSG00000038427 HEK293_OSMI2_2hA HEK293_TMG_2hB VCAN protein_coding processed_transcript 5.295164 5.954355 6.817313 0.6312842 0.2631008 0.1949518 0.1673576 0.4632104 0.08116803 0.46321036 0.081168025 -2.375882 0.03970000 0.06653333 0.01266667 -0.05386667 9.773259e-01 1.492814e-08 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000038427 E001 5.3887775 0.0033263459 4.468765e-02 9.962861e-02 5 83471618 83471673 56 + 0.886 0.602 -1.158
ENSG00000038427 E002 6.3872659 0.0034118932 5.741356e-02 1.221923e-01 5 83471674 83471743 70 + 0.938 0.686 -0.994
ENSG00000038427 E003 4.7920783 0.0670479443 3.255116e-01 4.689436e-01 5 83471744 83471763 20 + 0.810 0.650 -0.653
ENSG00000038427 E004 5.2058265 0.0206566640 7.570320e-02 1.526281e-01 5 83471764 83471776 13 + 0.872 0.603 -1.099
ENSG00000038427 E005 4.9949799 0.0085818113 3.986521e-04 1.769157e-03 5 83471777 83471790 14 + 0.926 0.359 -2.533
ENSG00000038427 E006 11.4330508 0.1252794524 3.168859e-03 1.076383e-02 5 83471791 83471924 134 + 1.239 0.691 -2.063
ENSG00000038427 E007 10.3964903 0.0415056718 2.445342e-03 8.598684e-03 5 83471925 83472023 99 + 1.185 0.725 -1.735
ENSG00000038427 E008 8.4319050 0.0444919804 1.684284e-04 8.284629e-04 5 83483513 83483588 76 + 1.134 0.497 -2.557
ENSG00000038427 E009 0.0000000       5 83483589 83483604 16 +      
ENSG00000038427 E010 30.8900404 0.0006553584 7.694502e-17 3.357209e-15 5 83490098 83490472 375 + 1.661 1.018 -2.251
ENSG00000038427 E011 20.8477665 0.0016964649 5.038013e-10 7.880090e-09 5 83493546 83493720 175 + 1.484 0.918 -2.017
ENSG00000038427 E012 16.8510766 0.0012549619 1.657592e-08 1.962171e-07 5 83493804 83493931 128 + 1.398 0.844 -2.004
ENSG00000038427 E013 0.1515154 0.0429963106 8.093370e-01   5 83512102 83512102 1 + 0.096 0.000 -9.556
ENSG00000038427 E014 26.3616143 0.0130550652 1.221462e-09 1.779881e-08 5 83512103 83512396 294 + 1.590 0.981 -2.143
ENSG00000038427 E015 1.8715242 0.0090836371 3.574914e-01 5.018911e-01 5 83512397 83512940 544 + 0.395 0.552 0.787
ENSG00000038427 E016 39.2618462 0.0006055648 8.322994e-22 6.480749e-20 5 83519349 83522309 2961 + 1.767 1.099 -2.314
ENSG00000038427 E017 0.7385489 0.0553692697 7.344495e-02 1.490336e-01 5 83535614 83537006 1393 + 0.350 0.000 -11.797
ENSG00000038427 E018 199.3799806 0.0124808428 3.345711e-12 7.537577e-11 5 83537007 83539684 2678 + 2.411 2.038 -1.245
ENSG00000038427 E019 246.5321928 0.0061427063 8.149189e-03 2.415968e-02 5 83539685 83541947 2263 + 2.422 2.329 -0.309
ENSG00000038427 E020 70.9609613 0.0003938720 6.207603e-06 4.326436e-05 5 83541948 83542268 321 + 1.763 1.950 0.630
ENSG00000038427 E021 0.1472490 0.0435802890 8.092580e-01   5 83544965 83545070 106 + 0.096 0.000 -9.555
ENSG00000038427 E022 45.6030352 0.0006201346 4.120358e-04 1.820659e-03 5 83545537 83545650 114 + 1.573 1.756 0.623
ENSG00000038427 E023 40.4120514 0.0022649077 2.445305e-02 6.075565e-02 5 83547971 83548084 114 + 1.543 1.675 0.450
ENSG00000038427 E024 0.0000000       5 83553362 83553363 2 +      
ENSG00000038427 E025 48.9937295 0.0008251418 4.689876e-02 1.036461e-01 5 83553364 83553522 159 + 1.642 1.743 0.344
ENSG00000038427 E026 34.4549304 0.0145287826 1.522091e-01 2.646873e-01 5 83554956 83555038 83 + 1.494 1.612 0.402
ENSG00000038427 E027 50.1644952 0.0005517930 1.612312e-03 5.999994e-03 5 83572416 83572560 145 + 1.632 1.788 0.527
ENSG00000038427 E028 57.4077728 0.0014248303 2.955678e-04 1.361865e-03 5 83579980 83580162 183 + 1.677 1.852 0.593
ENSG00000038427 E029 12.5535829 0.0026126999 9.294605e-01 9.595988e-01 5 83580163 83580306 144 + 1.118 1.128 0.033
ENSG00000038427 E030 284.6577787 0.0049010751 2.554027e-39 8.473778e-37 5 83580307 83582303 1997 + 2.216 2.650 1.448