ENSG00000038274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280969 ENSG00000038274 HEK293_OSMI2_2hA HEK293_TMG_2hB MAT2B protein_coding protein_coding 25.61057 16.24389 36.62763 4.032987 1.228956 1.172541 2.699174 1.032274 4.145504 0.5299408 0.08588783 1.9952890 0.0904375 0.05603333 0.1133333 0.0573000 0.07123866 0.02676617 FALSE TRUE
ENST00000321757 ENSG00000038274 HEK293_OSMI2_2hA HEK293_TMG_2hB MAT2B protein_coding protein_coding 25.61057 16.24389 36.62763 4.032987 1.228956 1.172541 20.376485 14.142796 27.974338 3.2319110 1.43026454 0.9835325 0.8140625 0.87806667 0.7633333 -0.1147333 0.02676617 0.02676617 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000038274 E001 0.9016039 0.2031340278 4.844850e-01 6.224811e-01 5 163503114 163503232 119 + 0.327 0.167 -1.265
ENSG00000038274 E002 1.2713423 0.1431840729 7.822129e-01 8.601820e-01 5 163503233 163503251 19 + 0.327 0.382 0.330
ENSG00000038274 E003 1.7163236 0.0857682866 8.326533e-01 8.951519e-01 5 163503252 163503262 11 + 0.410 0.459 0.257
ENSG00000038274 E004 26.4857231 0.0009001436 1.653112e-03 6.131830e-03 5 163503263 163503424 162 + 1.501 1.278 -0.772
ENSG00000038274 E005 0.4804688 0.0226572279 1.000000e+00 1.000000e+00 5 163504017 163504122 106 + 0.161 0.168 0.080
ENSG00000038274 E006 0.5922303 0.0178166421 7.753228e-01 8.552563e-01 5 163505545 163505578 34 + 0.223 0.168 -0.507
ENSG00000038274 E007 0.5879639 0.0204850154 7.754547e-01 8.553480e-01 5 163505579 163505583 5 + 0.223 0.168 -0.507
ENSG00000038274 E008 2.8161824 0.0053693432 3.774302e-03 1.250971e-02 5 163505584 163505595 12 + 0.701 0.168 -3.091
ENSG00000038274 E009 4.6660254 0.0034307277 1.224352e-02 3.411780e-02 5 163505596 163505598 3 + 0.848 0.461 -1.676
ENSG00000038274 E010 8.0992504 0.0022466366 2.068790e-01 3.348250e-01 5 163505599 163505613 15 + 0.998 0.854 -0.543
ENSG00000038274 E011 9.5783229 0.0020595225 1.323661e-01 2.373895e-01 5 163505614 163505618 5 + 1.070 0.908 -0.599
ENSG00000038274 E012 9.7298383 0.0026189946 1.153432e-01 2.133511e-01 5 163505619 163505620 2 + 1.078 0.908 -0.630
ENSG00000038274 E013 16.2264761 0.0011240799 2.203071e-02 5.574084e-02 5 163505621 163505625 5 + 1.292 1.092 -0.711
ENSG00000038274 E014 59.1385320 0.0004163973 9.039323e-06 6.070876e-05 5 163505626 163505648 23 + 1.835 1.620 -0.728
ENSG00000038274 E015 122.5216279 0.0007970728 1.382501e-03 5.249300e-03 5 163505649 163505749 101 + 2.117 2.007 -0.368
ENSG00000038274 E016 0.0000000       5 163505794 163505802 9 +      
ENSG00000038274 E017 0.0000000       5 163505803 163505817 15 +      
ENSG00000038274 E018 0.0000000       5 163505818 163505906 89 +      
ENSG00000038274 E019 0.0000000       5 163505907 163505941 35 +      
ENSG00000038274 E020 0.0000000       5 163505942 163505947 6 +      
ENSG00000038274 E021 0.0000000       5 163505948 163505948 1 +      
ENSG00000038274 E022 0.1515154 0.0459398654 1.000000e+00   5 163505949 163505981 33 + 0.088 0.000 -10.845
ENSG00000038274 E023 0.1451727 0.0448341590 1.000000e+00   5 163505982 163506066 85 + 0.088 0.000 -10.854
ENSG00000038274 E024 0.1451727 0.0448341590 1.000000e+00   5 163506067 163506086 20 + 0.088 0.000 -10.854
ENSG00000038274 E025 0.2966881 0.0271845430 5.275427e-01   5 163506087 163506350 264 + 0.161 0.000 -12.054
ENSG00000038274 E026 98.4495332 0.0003317755 6.032547e-03 1.869721e-02 5 163512002 163512004 3 + 2.021 1.925 -0.320
ENSG00000038274 E027 106.4270447 0.0003681488 8.526165e-02 1.678293e-01 5 163512005 163512008 4 + 2.041 1.986 -0.181
ENSG00000038274 E028 283.7735650 0.0001803378 1.776292e-04 8.680401e-04 5 163512009 163512196 188 + 2.469 2.395 -0.246
ENSG00000038274 E029 7.8413277 0.0020659904 1.931781e-07 1.856397e-06 5 163512197 163513264 1068 + 1.094 0.289 -3.593
ENSG00000038274 E030 2.5204247 0.0105384073 4.914246e-02 1.076251e-01 5 163513265 163513554 290 + 0.639 0.289 -1.829
ENSG00000038274 E031 125.3566850 0.0002597757 6.539569e-03 2.002719e-02 5 163513555 163513567 13 + 2.121 2.040 -0.271
ENSG00000038274 E032 204.3209786 0.0002588536 1.585136e-01 2.731358e-01 5 163513568 163513669 102 + 2.312 2.284 -0.093
ENSG00000038274 E033 0.5891098 0.0182739841 1.719579e-01 2.907484e-01 5 163513670 163513820 151 + 0.278 0.000 -13.190
ENSG00000038274 E034 2.1163407 0.1429218741 6.521776e-01 7.629089e-01 5 163513821 163513841 21 + 0.511 0.389 -0.632
ENSG00000038274 E035 213.3464134 0.0016691051 9.438265e-01 9.687606e-01 5 163513842 163513994 153 + 2.319 2.318 -0.004
ENSG00000038274 E036 12.8282491 0.0246693525 8.913972e-04 3.584110e-03 5 163513995 163515765 1771 + 1.239 0.793 -1.652
ENSG00000038274 E037 0.3030308 0.3894744382 6.528339e-01   5 163515802 163515812 11 + 0.161 0.000 -11.073
ENSG00000038274 E038 0.3030308 0.3894744382 6.528339e-01   5 163515813 163515822 10 + 0.161 0.000 -11.073
ENSG00000038274 E039 2.9895815 0.1287212534 8.210796e-02 1.628500e-01 5 163515823 163516517 695 + 0.701 0.288 -2.097
ENSG00000038274 E040 248.7587707 0.0006889013 7.696797e-01 8.512669e-01 5 163516518 163516645 128 + 2.382 2.398 0.052
ENSG00000038274 E041 212.4804293 0.0002204203 4.519839e-01 5.928860e-01 5 163516646 163516711 66 + 2.324 2.315 -0.031
ENSG00000038274 E042 6.3382280 0.0047797441 5.402748e-02 1.163121e-01 5 163516712 163517560 849 + 0.935 0.679 -1.010
ENSG00000038274 E043 266.6605478 0.0009516681 3.898628e-01 5.339092e-01 5 163517561 163517674 114 + 2.422 2.408 -0.050
ENSG00000038274 E044 3.7437194 0.0261046088 4.874860e-01 6.251668e-01 5 163517675 163518192 518 + 0.702 0.584 -0.507
ENSG00000038274 E045 811.1607580 0.0003415531 9.005469e-33 1.852399e-30 5 163518193 163519558 1366 + 2.838 2.994 0.518