ENSG00000038219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000040738 ENSG00000038219 HEK293_OSMI2_2hA HEK293_TMG_2hB BOD1L1 protein_coding protein_coding 9.452199 6.017457 12.55295 1.157645 0.5585006 1.059554 3.6887897 1.8001805 5.5097459 0.3190532 0.19472523 1.6084683 0.37377500 0.30163333 0.44183333 0.14020000 4.274659e-02 1.257459e-29 FALSE TRUE
ENST00000482713 ENSG00000038219 HEK293_OSMI2_2hA HEK293_TMG_2hB BOD1L1 protein_coding nonsense_mediated_decay 9.452199 6.017457 12.55295 1.157645 0.5585006 1.059554 0.3337911 0.4667274 0.3991581 0.0494794 0.01739163 -0.2205059 0.04332083 0.08263333 0.03190000 -0.05073333 1.111557e-02 1.257459e-29 FALSE TRUE
ENST00000507943 ENSG00000038219 HEK293_OSMI2_2hA HEK293_TMG_2hB BOD1L1 protein_coding protein_coding 9.452199 6.017457 12.55295 1.157645 0.5585006 1.059554 0.6673579 1.6899837 0.0000000 0.2171598 0.00000000 -7.4093771 0.09937500 0.29166667 0.00000000 -0.29166667 1.257459e-29 1.257459e-29 FALSE TRUE
ENST00000509897 ENSG00000038219 HEK293_OSMI2_2hA HEK293_TMG_2hB BOD1L1 protein_coding retained_intron 9.452199 6.017457 12.55295 1.157645 0.5585006 1.059554 0.5699547 0.2930700 1.1149747 0.2930700 0.76109507 1.8921694 0.05667083 0.04080000 0.08390000 0.04310000 6.946209e-01 1.257459e-29   FALSE
MSTRG.24637.2 ENSG00000038219 HEK293_OSMI2_2hA HEK293_TMG_2hB BOD1L1 protein_coding   9.452199 6.017457 12.55295 1.157645 0.5585006 1.059554 1.2242824 0.0000000 2.4396687 0.0000000 0.07566026 7.9364428 0.10561667 0.00000000 0.19463333 0.19463333 3.912786e-24 1.257459e-29 FALSE TRUE
MSTRG.24637.4 ENSG00000038219 HEK293_OSMI2_2hA HEK293_TMG_2hB BOD1L1 protein_coding   9.452199 6.017457 12.55295 1.157645 0.5585006 1.059554 1.3177407 1.1198132 2.0540414 0.6405085 0.39247575 0.8693877 0.13931667 0.15613333 0.16293333 0.00680000 8.665468e-01 1.257459e-29 FALSE TRUE
MSTRG.24637.8 ENSG00000038219 HEK293_OSMI2_2hA HEK293_TMG_2hB BOD1L1 protein_coding   9.452199 6.017457 12.55295 1.157645 0.5585006 1.059554 1.2447069 0.5310974 0.4449235 0.2655525 0.33942029 -0.2502643 0.13960000 0.10880000 0.03726667 -0.07153333 7.731928e-01 1.257459e-29 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000038219 E001 129.837931 0.0236655588 3.917560e-10 6.257757e-09 4 13568738 13569505 768 - 1.857 2.367 1.709
ENSG00000038219 E002 50.397280 0.0197834302 4.501759e-09 5.917192e-08 4 13569506 13569785 280 - 1.441 1.961 1.765
ENSG00000038219 E003 22.227915 0.0328813730 9.001811e-04 3.614442e-03 4 13569786 13569838 53 - 1.158 1.563 1.409
ENSG00000038219 E004 12.941903 0.0018347382 3.908275e-05 2.258203e-04 4 13569839 13569855 17 - 0.941 1.349 1.466
ENSG00000038219 E005 10.678517 0.0016925076 2.362299e-04 1.117625e-03 4 13569856 13569856 1 - 0.870 1.265 1.442
ENSG00000038219 E006 22.901650 0.0150462692 5.885806e-03 1.831130e-02 4 13569857 13569889 33 - 1.240 1.512 0.942
ENSG00000038219 E007 79.806671 0.0014363782 2.340506e-08 2.692143e-07 4 13569890 13570128 239 - 1.767 2.033 0.895
ENSG00000038219 E008 18.715959 0.0488287831 2.669784e-02 6.536178e-02 4 13572702 13572842 141 - 1.139 1.450 1.090
ENSG00000038219 E009 81.236895 0.0003142721 4.745141e-08 5.143927e-07 4 13576838 13576991 154 - 1.781 2.026 0.824
ENSG00000038219 E010 67.495442 0.0007952148 3.238861e-04 1.476401e-03 4 13577403 13577487 85 - 1.725 1.914 0.638
ENSG00000038219 E011 0.000000       4 13577581 13577581 1 -      
ENSG00000038219 E012 46.291461 0.0005787592 4.055422e-02 9.203693e-02 4 13577582 13577631 50 - 1.581 1.717 0.462
ENSG00000038219 E013 1.771482 0.0079216748 1.392779e-02 3.806210e-02 4 13577632 13578201 570 - 0.514 0.000 -11.033
ENSG00000038219 E014 40.184436 0.0006390855 5.136544e-02 1.115803e-01 4 13579928 13579969 42 - 1.519 1.657 0.471
ENSG00000038219 E015 26.600685 0.0063797647 8.390388e-02 1.656576e-01 4 13579970 13579973 4 - 1.334 1.500 0.574
ENSG00000038219 E016 2.396089 0.0066588507 5.392152e-01 6.704957e-01 4 13579974 13580066 93 - 0.460 0.581 0.575
ENSG00000038219 E017 34.964230 0.0008064868 1.232871e-01 2.246583e-01 4 13581020 13581051 32 - 1.467 1.587 0.414
ENSG00000038219 E018 20.922397 0.0008590730 8.121288e-02 1.614432e-01 4 13581052 13581054 3 - 1.241 1.401 0.559
ENSG00000038219 E019 1.475722 0.5819974138 2.979127e-01 4.392968e-01 4 13581128 13581131 4 - 0.288 0.515 1.272
ENSG00000038219 E020 41.845368 0.0005502523 1.879009e-01 3.110925e-01 4 13581132 13581207 76 - 1.553 1.652 0.338
ENSG00000038219 E021 0.000000       4 13582230 13582236 7 -      
ENSG00000038219 E022 38.143020 0.0005348344 9.084612e-01 9.458648e-01 4 13582237 13582310 74 - 1.539 1.568 0.100
ENSG00000038219 E023 46.113114 0.0005405307 7.388873e-01 8.286590e-01 4 13582652 13582736 85 - 1.626 1.629 0.010
ENSG00000038219 E024 47.340787 0.0023472065 9.893046e-01 9.973187e-01 4 13586396 13586475 80 - 1.628 1.653 0.084
ENSG00000038219 E025 44.113353 0.0035166848 9.269056e-01 9.579947e-01 4 13587699 13587771 73 - 1.594 1.626 0.108
ENSG00000038219 E026 43.065029 0.0178443783 7.173020e-01 8.127289e-01 4 13588722 13588792 71 - 1.573 1.645 0.245
ENSG00000038219 E027 34.041716 0.0045213322 7.508922e-01 8.374795e-01 4 13590386 13590446 61 - 1.480 1.529 0.165
ENSG00000038219 E028 33.987187 0.0005964458 3.311530e-01 4.747401e-01 4 13591923 13591966 44 - 1.469 1.554 0.292
ENSG00000038219 E029 6.129669 0.0246091610 1.318267e-01 2.366659e-01 4 13591967 13593520 1554 - 0.870 0.640 -0.930
ENSG00000038219 E030 43.598045 0.0043010151 4.314024e-01 5.739522e-01 4 13595860 13595944 85 - 1.577 1.654 0.262
ENSG00000038219 E031 36.137086 0.0198228565 4.988251e-01 6.352277e-01 4 13597104 13597168 65 - 1.534 1.507 -0.090
ENSG00000038219 E032 179.140716 0.0002813294 2.522562e-01 3.885836e-01 4 13598946 13599966 1021 - 2.212 2.201 -0.036
ENSG00000038219 E033 236.498940 0.0003209247 7.784340e-07 6.619921e-06 4 13599967 13601540 1574 - 2.356 2.248 -0.360
ENSG00000038219 E034 56.430373 0.0004190790 6.252705e-03 1.927644e-02 4 13601541 13601831 291 - 1.744 1.618 -0.429
ENSG00000038219 E035 29.831472 0.0082570980 2.199558e-01 3.503662e-01 4 13601832 13601933 102 - 1.464 1.383 -0.281
ENSG00000038219 E036 336.426577 0.0020841579 2.810687e-36 7.426445e-34 4 13601934 13605084 3151 - 2.561 2.194 -1.224
ENSG00000038219 E037 9.442351 0.0163811401 2.306824e-04 1.094550e-03 4 13607117 13607121 5 - 1.077 0.513 -2.275
ENSG00000038219 E038 17.137205 0.0146925393 1.723472e-04 8.453462e-04 4 13607122 13607189 68 - 1.302 0.859 -1.612
ENSG00000038219 E039 25.550590 0.0066846487 2.446606e-08 2.803158e-07 4 13608530 13608668 139 - 1.483 0.920 -2.006
ENSG00000038219 E040 25.927540 0.0030680203 3.507851e-07 3.200191e-06 4 13609295 13609406 112 - 1.480 1.023 -1.613
ENSG00000038219 E041 33.265391 0.0030532039 1.312976e-07 1.303948e-06 4 13610934 13611100 167 - 1.579 1.161 -1.455
ENSG00000038219 E042 0.000000       4 13613506 13613511 6 -      
ENSG00000038219 E043 25.405680 0.0217989386 1.298245e-03 4.970669e-03 4 13613512 13613661 150 - 1.458 1.105 -1.239
ENSG00000038219 E044 60.802137 0.0011869946 6.175079e-10 9.526468e-09 4 13614196 13614810 615 - 1.824 1.480 -1.167
ENSG00000038219 E045 31.060900 0.0007266426 9.467629e-11 1.677215e-09 4 13615312 13615502 191 - 1.564 1.023 -1.900
ENSG00000038219 E046 19.989786 0.0122740904 1.323222e-06 1.070597e-05 4 13619943 13620067 125 - 1.387 0.820 -2.061
ENSG00000038219 E047 43.622346 0.0099555483 1.537262e-19 9.325318e-18 4 13623390 13626312 2923 - 1.298 1.959 2.256
ENSG00000038219 E048 21.981028 0.0130210211 8.559485e-02 1.683540e-01 4 13627345 13627725 381 - 1.363 1.208 -0.543