ENSG00000038002

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264595 ENSG00000038002 HEK293_OSMI2_2hA HEK293_TMG_2hB AGA protein_coding protein_coding 11.12881 4.370337 21.89412 0.8354554 1.049188 2.322089 4.748489 2.498981 8.380852 0.5150681 0.07791726 1.741716 0.4557833 0.5711667 0.3842667 -0.18690000 1.446605e-03 1.193479e-12 FALSE TRUE
ENST00000510635 ENSG00000038002 HEK293_OSMI2_2hA HEK293_TMG_2hB AGA protein_coding protein_coding 11.12881 4.370337 21.89412 0.8354554 1.049188 2.322089 1.208641 0.000000 3.833856 0.0000000 0.61473793 8.586410 0.0630750 0.0000000 0.1732667 0.17326667 1.193479e-12 1.193479e-12 FALSE FALSE
MSTRG.25758.2 ENSG00000038002 HEK293_OSMI2_2hA HEK293_TMG_2hB AGA protein_coding   11.12881 4.370337 21.89412 0.8354554 1.049188 2.322089 4.601501 1.688232 8.938797 0.3203091 0.38228646 2.397660 0.4209125 0.3878000 0.4093333 0.02153333 8.699635e-01 1.193479e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000038002 E001 71.6580020 0.0035513736 7.986398e-01 8.715191e-01 4 177430774 177431562 789 - 1.825 1.810 -0.050
ENSG00000038002 E002 76.3408769 0.0004052846 9.461748e-05 4.967575e-04 4 177431563 177431808 246 - 1.798 1.962 0.553
ENSG00000038002 E003 59.6676579 0.0004607043 6.509871e-03 1.994752e-02 4 177433214 177433260 47 - 1.700 1.831 0.441
ENSG00000038002 E004 87.2731997 0.0002955486 3.603208e-03 1.201960e-02 4 177433261 177433347 87 - 1.871 1.986 0.387
ENSG00000038002 E005 46.5453532 0.0004888304 6.957897e-02 1.426603e-01 4 177434382 177434383 2 - 1.610 1.709 0.338
ENSG00000038002 E006 69.0644062 0.0003653644 8.019137e-02 1.598453e-01 4 177434384 177434439 56 - 1.784 1.862 0.266
ENSG00000038002 E007 67.5071263 0.0003843920 1.166766e-01 2.152207e-01 4 177434440 177434481 42 - 1.777 1.849 0.242
ENSG00000038002 E008 49.4865088 0.0004393023 2.905665e-01 4.313854e-01 4 177434482 177434489 8 - 1.648 1.704 0.193
ENSG00000038002 E009 44.1531985 0.0006618798 2.288125e-02 5.749508e-02 4 177436276 177436297 22 - 1.577 1.704 0.433
ENSG00000038002 E010 70.0941733 0.0004221461 1.603899e-01 2.756544e-01 4 177436298 177436351 54 - 1.795 1.859 0.215
ENSG00000038002 E011 3.2087229 0.0049078506 2.537591e-01 3.903497e-01 4 177437068 177437404 337 - 0.637 0.433 -0.963
ENSG00000038002 E012 104.2280720 0.0003653249 4.598152e-01 5.999031e-01 4 177437405 177437519 115 - 1.992 1.965 -0.092
ENSG00000038002 E013 110.6021187 0.0003151522 1.096375e-02 3.107728e-02 4 177438745 177438857 113 - 2.031 1.934 -0.325
ENSG00000038002 E014 114.2115165 0.0002990730 7.254430e-04 2.990534e-03 4 177439576 177439688 113 - 2.051 1.923 -0.431
ENSG00000038002 E015 0.9986021 0.0134202352 6.243436e-01 7.406759e-01 4 177440042 177440272 231 - 0.241 0.331 0.624
ENSG00000038002 E016 131.5412792 0.0002467985 2.913999e-06 2.186456e-05 4 177440273 177440426 154 - 2.121 1.954 -0.558
ENSG00000038002 E017 91.1233704 0.0003687903 7.031982e-05 3.816720e-04 4 177442249 177442646 398 - 1.963 1.789 -0.585