ENSG00000037280

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261937 ENSG00000037280 HEK293_OSMI2_2hA HEK293_TMG_2hB FLT4 protein_coding protein_coding 31.43627 48.60512 26.4997 2.8089 0.5076031 -0.8748849 5.458518 8.072858 4.269944 0.4630164 0.27124193 -0.9172737 0.1758333 0.1671333 0.1608667 -0.006266667 9.322046e-01 8.265296e-09 FALSE TRUE
ENST00000502603 ENSG00000037280 HEK293_OSMI2_2hA HEK293_TMG_2hB FLT4 protein_coding retained_intron 31.43627 48.60512 26.4997 2.8089 0.5076031 -0.8748849 3.980443 4.230188 5.045781 0.5060912 0.29631134 0.2538058 0.1402708 0.0866000 0.1902333 0.103633333 7.451961e-08 8.265296e-09 FALSE TRUE
ENST00000514810 ENSG00000037280 HEK293_OSMI2_2hA HEK293_TMG_2hB FLT4 protein_coding retained_intron 31.43627 48.60512 26.4997 2.8089 0.5076031 -0.8748849 5.163153 6.995873 4.192247 1.3764788 0.38540508 -0.7374038 0.1597458 0.1415000 0.1581000 0.016600000 8.222009e-01 8.265296e-09 FALSE FALSE
MSTRG.27469.5 ENSG00000037280 HEK293_OSMI2_2hA HEK293_TMG_2hB FLT4 protein_coding   31.43627 48.60512 26.4997 2.8089 0.5076031 -0.8748849 12.366433 24.143065 7.977096 0.5647292 0.07935121 -1.5964634 0.3694708 0.4989333 0.3011667 -0.197766667 8.265296e-09 8.265296e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000037280 E001 37.988994 0.0169424766 4.950669e-01 6.319370e-01 5 180601506 180601592 87 - 1.579 1.525 -0.182
ENSG00000037280 E002 672.680323 0.0010081568 6.001952e-04 2.533820e-03 5 180601593 180603088 1496 - 2.821 2.759 -0.207
ENSG00000037280 E003 205.839907 0.0009156169 2.506044e-06 1.908593e-05 5 180603089 180603390 302 - 2.354 2.220 -0.448
ENSG00000037280 E004 1.696058 0.0130588404 1.357469e-02 3.724866e-02 5 180607688 180607758 71 - 0.000 0.502 12.520
ENSG00000037280 E005 11.218083 0.0077632443 6.385820e-02 1.331222e-01 5 180607759 180607785 27 - 0.864 1.092 0.847
ENSG00000037280 E006 30.935925 0.0076052622 8.500879e-05 4.516929e-04 5 180607786 180607807 22 - 1.178 1.531 1.230
ENSG00000037280 E007 75.287612 0.0036097515 7.125557e-04 2.943595e-03 5 180607808 180607830 23 - 1.686 1.880 0.653
ENSG00000037280 E008 119.904852 0.0058307128 2.017557e-05 1.250107e-04 5 180607831 180607906 76 - 1.851 2.086 0.791
ENSG00000037280 E009 76.577026 0.0011941123 3.491749e-07 3.186730e-06 5 180607907 180607908 2 - 1.636 1.899 0.890
ENSG00000037280 E010 126.648437 0.0069504030 9.696321e-07 8.066302e-06 5 180607909 180607964 56 - 1.836 2.117 0.946
ENSG00000037280 E011 80.763923 0.0060560599 1.585240e-04 7.851682e-04 5 180607965 180607967 3 - 1.682 1.916 0.790
ENSG00000037280 E012 104.998545 0.0074432731 6.110414e-05 3.369370e-04 5 180607968 180607991 24 - 1.787 2.031 0.824
ENSG00000037280 E013 240.188680 0.0023650903 3.140338e-12 7.110405e-11 5 180607992 180608159 168 - 2.132 2.389 0.858
ENSG00000037280 E014 168.440124 0.0005482260 3.396919e-08 3.787288e-07 5 180608160 180608284 125 - 2.032 2.221 0.630
ENSG00000037280 E015 1.843524 0.0478633597 3.454264e-01 4.895236e-01 5 180608965 180608967 3 - 0.535 0.364 -0.887
ENSG00000037280 E016 305.789608 0.0003545159 5.414389e-01 6.724267e-01 5 180608968 180609053 86 - 2.441 2.430 -0.036
ENSG00000037280 E017 8.045758 0.0020667280 5.521501e-04 2.355026e-03 5 180609054 180609158 105 - 1.149 0.764 -1.448
ENSG00000037280 E018 36.319661 0.0021520589 4.900047e-04 2.122166e-03 5 180609159 180609904 746 - 1.668 1.455 -0.731
ENSG00000037280 E019 327.663482 0.0015268515 7.605326e-01 8.446117e-01 5 180609905 180610025 121 - 2.467 2.463 -0.013
ENSG00000037280 E020 347.952378 0.0001455142 5.576615e-02 1.192919e-01 5 180611331 180611479 149 - 2.458 2.501 0.145
ENSG00000037280 E021 16.782429 0.0010573435 4.562129e-05 2.596064e-04 5 180611480 180611716 237 - 1.419 1.084 -1.181
ENSG00000037280 E022 12.362531 0.0118951801 3.808440e-03 1.260390e-02 5 180612403 180612505 103 - 1.267 0.961 -1.103
ENSG00000037280 E023 262.044093 0.0002059684 5.223339e-02 1.131323e-01 5 180612506 180612611 106 - 2.330 2.381 0.170
ENSG00000037280 E024 267.464380 0.0017221852 1.945095e-01 3.194006e-01 5 180613011 180613110 100 - 2.342 2.386 0.147
ENSG00000037280 E025 33.688488 0.0006379231 1.608432e-09 2.294523e-08 5 180613111 180614067 957 - 1.720 1.358 -1.237
ENSG00000037280 E026 136.480297 0.0002764149 8.882151e-01 9.325416e-01 5 180614068 180614075 8 - 2.077 2.085 0.026
ENSG00000037280 E027 131.310099 0.0002993717 8.306323e-01 8.937590e-01 5 180614076 180614085 10 - 2.070 2.066 -0.014
ENSG00000037280 E028 214.998724 0.0003232787 6.614768e-01 7.699224e-01 5 180614086 180614179 94 - 2.268 2.283 0.051
ENSG00000037280 E029 274.201416 0.0001735538 6.542068e-01 7.644613e-01 5 180616367 180616489 123 - 2.375 2.389 0.046
ENSG00000037280 E030 220.109377 0.0003077168 9.336848e-01 9.622192e-01 5 180616900 180616994 95 - 2.291 2.292 0.003
ENSG00000037280 E031 2.055302 0.0073392119 2.647002e-01 4.026810e-01 5 180618523 180618769 247 - 0.295 0.503 1.169
ENSG00000037280 E032 181.604191 0.0006926397 6.055247e-01 7.258917e-01 5 180618770 180618920 151 - 2.216 2.204 -0.042
ENSG00000037280 E033 35.104701 0.0325175436 1.760687e-01 2.961002e-01 5 180618921 180619020 100 - 1.595 1.463 -0.452
ENSG00000037280 E034 62.661638 0.0004436358 2.179719e-02 5.525319e-02 5 180619021 180619109 89 - 1.823 1.717 -0.358
ENSG00000037280 E035 26.255094 0.0252630360 9.011956e-04 3.617940e-03 5 180619110 180619252 143 - 1.595 1.266 -1.138
ENSG00000037280 E036 60.709817 0.0054689348 3.383363e-02 7.942208e-02 5 180619253 180619366 114 - 1.820 1.699 -0.408
ENSG00000037280 E037 5.901497 0.0062205194 2.051638e-06 1.592024e-05 5 180619367 180619664 298 - 1.134 0.532 -2.392
ENSG00000037280 E038 25.686593 0.0009111889 8.921558e-01 9.351140e-01 5 180619665 180619769 105 - 1.385 1.379 -0.024
ENSG00000037280 E039 29.622463 0.0018709229 6.553140e-01 7.652398e-01 5 180620173 180620308 136 - 1.450 1.421 -0.100
ENSG00000037280 E040 27.182764 0.0019494735 7.965881e-02 1.590180e-01 5 180620609 180620715 107 - 1.479 1.355 -0.428
ENSG00000037280 E041 25.104522 0.0007843661 1.515167e-01 2.637326e-01 5 180620876 180620974 99 - 1.435 1.333 -0.353
ENSG00000037280 E042 17.483993 0.0010771128 2.003747e-01 3.266843e-01 5 180620975 180621007 33 - 1.289 1.182 -0.378
ENSG00000037280 E043 1.704772 0.0082811813 3.613595e-05 2.104989e-04 5 180621008 180621105 98 - 0.767 0.086 -4.474
ENSG00000037280 E044 35.573999 0.0008050105 2.601784e-03 9.070168e-03 5 180621106 180621252 147 - 1.631 1.449 -0.624
ENSG00000037280 E045 55.229843 0.0031677220 2.239346e-04 1.065950e-03 5 180621542 180621904 363 - 1.829 1.628 -0.681
ENSG00000037280 E046 22.609063 0.0008308297 2.055502e-03 7.397442e-03 5 180622731 180622839 109 - 1.472 1.245 -0.787
ENSG00000037280 E047 27.527165 0.0007658912 1.466751e-02 3.974233e-02 5 180623935 180624061 127 - 1.519 1.354 -0.568
ENSG00000037280 E048 28.257705 0.0165241832 3.237127e-01 4.670431e-01 5 180625869 180626031 163 - 1.479 1.391 -0.302
ENSG00000037280 E049 29.707667 0.0006657362 3.590659e-02 8.340052e-02 5 180626111 180626265 155 - 1.531 1.394 -0.472
ENSG00000037280 E050 16.831073 0.0010630817 4.190539e-02 9.455177e-02 5 180628882 180628927 46 - 1.320 1.149 -0.603
ENSG00000037280 E051 23.520626 0.0008864277 2.072591e-01 3.352284e-01 5 180628928 180628999 72 - 1.402 1.310 -0.320
ENSG00000037280 E052 34.566156 0.0105664066 1.353771e-01 2.416361e-01 5 180629259 180629423 165 - 1.573 1.460 -0.386
ENSG00000037280 E053 13.725267 0.0338611003 4.205645e-01 5.637692e-01 5 180629424 180629427 4 - 1.178 1.084 -0.338
ENSG00000037280 E054 22.570225 0.0202830451 7.994921e-02 1.594851e-01 5 180629696 180629778 83 - 1.434 1.266 -0.585
ENSG00000037280 E055 16.370413 0.0011428204 4.072568e-02 9.236962e-02 5 180629779 180629835 57 - 1.310 1.135 -0.616
ENSG00000037280 E056 24.579786 0.0010365244 1.074990e-02 3.056760e-02 5 180629943 180630105 163 - 1.479 1.296 -0.632
ENSG00000037280 E057 17.301960 0.0010885845 3.479669e-01 4.921739e-01 5 180630225 180630288 64 - 1.266 1.188 -0.278
ENSG00000037280 E058 16.358077 0.0017600945 1.788134e-01 2.996532e-01 5 180630289 180630337 49 - 1.266 1.149 -0.415
ENSG00000037280 E059 0.699736 0.0166919434 1.779492e-01 2.985630e-01 5 180630338 180630355 18 - 0.000 0.272 11.194
ENSG00000037280 E060 29.430956 0.0181274295 1.926090e-02 4.990045e-02 5 180630555 180630799 245 - 1.567 1.361 -0.710
ENSG00000037280 E061 15.323378 0.0169826444 7.493366e-03 2.249542e-02 5 180631682 180631778 97 - 1.340 1.064 -0.981
ENSG00000037280 E062 9.970841 0.0092874069 1.494175e-04 7.444623e-04 5 180649488 180649625 138 - 1.243 0.826 -1.534