ENSG00000036672

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260187 ENSG00000036672 HEK293_OSMI2_2hA HEK293_TMG_2hB USP2 protein_coding protein_coding 7.693564 9.78799 7.255606 0.5839028 0.2605328 -0.4314026 0.8121268 1.0449124 0.701235 0.08601616 0.07961424 -0.5687251 0.1006292 0.1082000 0.0962000 -0.0120000 8.353169e-01 7.053172e-06 FALSE TRUE
ENST00000455332 ENSG00000036672 HEK293_OSMI2_2hA HEK293_TMG_2hB USP2 protein_coding protein_coding 7.693564 9.78799 7.255606 0.5839028 0.2605328 -0.4314026 4.9891752 7.5461373 3.825915 0.41723811 0.13477006 -0.9780782 0.6350042 0.7714333 0.5298000 -0.2416333 7.053172e-06 7.053172e-06 FALSE TRUE
ENST00000525735 ENSG00000036672 HEK293_OSMI2_2hA HEK293_TMG_2hB USP2 protein_coding protein_coding 7.693564 9.78799 7.255606 0.5839028 0.2605328 -0.4314026 1.4743793 0.7722202 2.402912 0.39696521 0.43333630 1.6251287 0.2126167 0.0746000 0.3284333 0.2538333 2.321845e-01 7.053172e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000036672 E001 301.728064 0.0072668032 1.025692e-09 1.518437e-08 11 119355215 119356533 1319 - 2.281 2.556 0.918
ENSG00000036672 E002 106.631029 0.0002968584 7.370980e-02 1.494638e-01 11 119356534 119356922 389 - 1.947 2.053 0.355
ENSG00000036672 E003 71.357815 0.0009448152 7.768035e-01 8.562836e-01 11 119357187 119357307 121 - 1.804 1.860 0.191
ENSG00000036672 E004 65.486531 0.0004020180 9.322483e-01 9.613297e-01 11 119357483 119357590 108 - 1.780 1.820 0.136
ENSG00000036672 E005 65.420457 0.0008953723 4.958868e-03 1.581660e-02 11 119357757 119357835 79 - 1.852 1.771 -0.272
ENSG00000036672 E006 57.043763 0.0020751676 3.626286e-05 2.111603e-04 11 119357981 119358034 54 - 1.843 1.683 -0.541
ENSG00000036672 E007 47.338420 0.0008122979 6.497379e-03 1.991666e-02 11 119358035 119358061 27 - 1.729 1.634 -0.322
ENSG00000036672 E008 62.046608 0.0004555945 3.077725e-05 1.826246e-04 11 119358149 119358252 104 - 1.867 1.729 -0.468
ENSG00000036672 E009 2.104598 0.0071243395 3.486281e-01 4.928599e-01 11 119358665 119358772 108 - 0.557 0.432 -0.614
ENSG00000036672 E010 60.841730 0.0004284343 2.162875e-03 7.729094e-03 11 119358773 119358837 65 - 1.831 1.738 -0.313
ENSG00000036672 E011 73.030279 0.0003867155 6.285819e-03 1.936157e-02 11 119359024 119359134 111 - 1.893 1.826 -0.226
ENSG00000036672 E012 0.810555 0.0141562705 7.606186e-02 1.532140e-01 11 119359135 119359230 96 - 0.396 0.109 -2.390
ENSG00000036672 E013 58.574549 0.0044153036 3.728630e-01 5.172920e-01 11 119359231 119359342 112 - 1.758 1.755 -0.011
ENSG00000036672 E014 45.122468 0.0133086413 6.156903e-01 7.339031e-01 11 119359537 119359660 124 - 1.635 1.649 0.048
ENSG00000036672 E015 22.680727 0.0008579089 4.397351e-03 1.425675e-02 11 119360184 119360234 51 - 1.450 1.289 -0.559
ENSG00000036672 E016 17.002116 0.0010829631 2.293671e-03 8.130549e-03 11 119363849 119364207 359 - 1.354 1.148 -0.726
ENSG00000036672 E017 9.652883 0.0017818160 5.357166e-01 6.675167e-01 11 119372707 119372977 271 - 1.029 1.004 -0.092
ENSG00000036672 E018 5.785198 0.0029133937 3.176471e-01 4.605387e-01 11 119372978 119373067 90 - 0.708 0.877 0.673
ENSG00000036672 E019 12.400798 0.0083432290 4.484471e-01 5.897414e-01 11 119373068 119373521 454 - 1.044 1.164 0.434
ENSG00000036672 E020 0.000000       11 119376224 119376356 133 -      
ENSG00000036672 E021 0.000000       11 119379007 119379115 109 -      
ENSG00000036672 E022 4.125470 0.0039855524 3.734721e-01 5.179170e-01 11 119381473 119381711 239 - 0.600 0.765 0.695