ENSG00000036448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262113 ENSG00000036448 HEK293_OSMI2_2hA HEK293_TMG_2hB MYOM2 protein_coding protein_coding 1.635862 2.597853 1.310617 0.1543207 0.1829088 -0.9816505 0.63009162 0.8032655 0.63548000 0.19422080 0.02351061 -0.3333539 0.43871667 0.31990000 0.5052333 0.18533333 0.44088620 0.04299397 FALSE TRUE
ENST00000518513 ENSG00000036448 HEK293_OSMI2_2hA HEK293_TMG_2hB MYOM2 protein_coding retained_intron 1.635862 2.597853 1.310617 0.1543207 0.1829088 -0.9816505 0.12627308 0.0730920 0.00000000 0.07309200 0.00000000 -3.0547096 0.05713750 0.02576667 0.0000000 -0.02576667 0.82875030 0.04299397 FALSE TRUE
ENST00000520298 ENSG00000036448 HEK293_OSMI2_2hA HEK293_TMG_2hB MYOM2 protein_coding processed_transcript 1.635862 2.597853 1.310617 0.1543207 0.1829088 -0.9816505 0.46242267 1.1771642 0.24244851 0.03690166 0.08309537 -2.2334583 0.25304583 0.45686667 0.1901333 -0.26673333 0.04299397 0.04299397 FALSE TRUE
ENST00000523438 ENSG00000036448 HEK293_OSMI2_2hA HEK293_TMG_2hB MYOM2 protein_coding protein_coding 1.635862 2.597853 1.310617 0.1543207 0.1829088 -0.9816505 0.12451406 0.1982198 0.00000000 0.19821984 0.00000000 -4.3800356 0.06567500 0.06990000 0.0000000 -0.06990000 0.85375434 0.04299397 FALSE TRUE
ENST00000523443 ENSG00000036448 HEK293_OSMI2_2hA HEK293_TMG_2hB MYOM2 protein_coding retained_intron 1.635862 2.597853 1.310617 0.1543207 0.1829088 -0.9816505 0.07943575 0.0000000 0.35955165 0.00000000 0.18005962 5.2077041 0.04584167 0.00000000 0.2442000 0.24420000 0.08488750 0.04299397 FALSE FALSE
ENST00000612167 ENSG00000036448 HEK293_OSMI2_2hA HEK293_TMG_2hB MYOM2 protein_coding processed_transcript 1.635862 2.597853 1.310617 0.1543207 0.1829088 -0.9816505 0.12243018 0.1244177 0.02230044 0.12441772 0.02230044 -2.0570976 0.08786250 0.04390000 0.0229000 -0.02100000 1.00000000 0.04299397 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000036448 E001 0.6955713 0.017550732 5.497845e-01 6.794892e-01 8 2045046 2045068 23 + 0.275 0.170 -0.885
ENSG00000036448 E002 3.3713315 0.075456949 6.747665e-01 7.802196e-01 8 2045069 2045168 100 + 0.657 0.590 -0.291
ENSG00000036448 E003 5.4685528 0.026707815 8.031522e-01 8.746941e-01 8 2050755 2050873 119 + 0.800 0.764 -0.141
ENSG00000036448 E004 7.2000997 0.024441170 8.253644e-01 8.900081e-01 8 2052158 2052313 156 + 0.857 0.889 0.120
ENSG00000036448 E005 6.6342372 0.003382900 2.060160e-01 3.337049e-01 8 2057348 2057486 139 + 0.953 0.797 -0.598
ENSG00000036448 E006 7.5148463 0.002442605 6.362108e-01 7.502865e-01 8 2057623 2057780 158 + 0.931 0.873 -0.219
ENSG00000036448 E007 6.0736695 0.100440440 4.921254e-01 6.293230e-01 8 2059153 2059245 93 + 0.884 0.774 -0.429
ENSG00000036448 E008 5.9088032 0.194800260 6.029308e-01 7.238035e-01 8 2069278 2069366 89 + 0.885 0.760 -0.491
ENSG00000036448 E009 4.7262194 0.067804494 7.533151e-01 8.393023e-01 8 2069447 2069497 51 + 0.769 0.706 -0.256
ENSG00000036448 E010 5.8605180 0.002988563 1.069914e-01 2.010953e-01 8 2072345 2072509 165 + 0.931 0.725 -0.804
ENSG00000036448 E011 3.7967940 0.041336925 2.156224e-01 3.451620e-01 8 2073339 2073500 162 + 0.769 0.564 -0.869
ENSG00000036448 E012 5.8823739 0.046159893 5.810657e-01 7.056695e-01 8 2076141 2076282 142 + 0.857 0.768 -0.349
ENSG00000036448 E013 7.0949603 0.017032831 2.267194e-01 3.584791e-01 8 2078734 2078933 200 + 0.973 0.815 -0.604
ENSG00000036448 E014 5.3717424 0.045279091 5.261635e-01 6.594299e-01 8 2079560 2079613 54 + 0.830 0.730 -0.396
ENSG00000036448 E015 0.0000000       8 2081788 2082182 395 +      
ENSG00000036448 E016 0.0000000       8 2085000 2085021 22 +      
ENSG00000036448 E017 6.9132545 0.023198971 4.056743e-01 5.493283e-01 8 2085263 2085390 128 + 0.931 0.817 -0.435
ENSG00000036448 E018 8.6081084 0.009867397 6.306707e-01 7.458234e-01 8 2090008 2090191 184 + 0.994 0.937 -0.211
ENSG00000036448 E019 6.5038648 0.017440140 7.534946e-01 8.394036e-01 8 2092346 2092520 175 + 0.883 0.842 -0.160
ENSG00000036448 E020 3.9189753 0.091485193 5.732926e-01 6.992337e-01 8 2093970 2094091 122 + 0.736 0.618 -0.495
ENSG00000036448 E021 7.6413445 0.013979357 2.465717e-01 3.819295e-01 8 2096247 2096434 188 + 0.994 0.846 -0.560
ENSG00000036448 E022 0.0000000       8 2098045 2098111 67 +      
ENSG00000036448 E023 6.9977571 0.002468842 8.897654e-01 9.335382e-01 8 2098857 2098983 127 + 0.857 0.873 0.061
ENSG00000036448 E024 0.0000000       8 2100444 2100499 56 +      
ENSG00000036448 E025 8.0713986 0.002121618 7.902886e-01 8.658413e-01 8 2100876 2101054 179 + 0.908 0.937 0.112
ENSG00000036448 E026 0.0000000       8 2102003 2102262 260 +      
ENSG00000036448 E027 7.6944481 0.003492324 7.222319e-01 8.163951e-01 8 2102667 2102781 115 + 0.931 0.887 -0.166
ENSG00000036448 E028 8.7064892 0.003718371 5.120155e-01 6.469500e-01 8 2106242 2106398 157 + 0.908 0.983 0.281
ENSG00000036448 E029 5.5574834 0.043437176 4.543004e-01 5.949454e-01 8 2106491 2106597 107 + 0.697 0.815 0.476
ENSG00000036448 E030 4.3082938 0.059336529 9.655826e-01 9.823726e-01 8 2108786 2108830 45 + 0.697 0.703 0.024
ENSG00000036448 E031 0.0000000       8 2109287 2109394 108 +      
ENSG00000036448 E032 6.9736863 0.005204656 2.310018e-01 3.636730e-01 8 2109395 2109531 137 + 0.974 0.828 -0.552
ENSG00000036448 E033 10.5844365 0.001772214 2.010222e-02 5.170114e-02 8 2115960 2116104 145 + 1.181 0.949 -0.843
ENSG00000036448 E034 8.2022029 0.008899125 6.783530e-01 7.828569e-01 8 2116216 2116275 60 + 0.974 0.924 -0.186
ENSG00000036448 E035 8.0412242 0.002218654 5.973723e-01 7.191540e-01 8 2117885 2117952 68 + 0.974 0.912 -0.229
ENSG00000036448 E036 0.0000000       8 2118865 2119211 347 +      
ENSG00000036448 E037 0.0000000       8 2119258 2119451 194 +      
ENSG00000036448 E038 10.7788660 0.008917007 4.482239e-02 9.987728e-02 8 2123252 2123365 114 + 1.181 0.971 -0.764
ENSG00000036448 E039 9.2557470 0.002164881 2.781600e-01 4.177925e-01 8 2123555 2123642 88 + 1.065 0.949 -0.429
ENSG00000036448 E040 6.2248691 0.002718490 7.368723e-01 8.271999e-01 8 2124179 2124217 39 + 0.857 0.813 -0.171
ENSG00000036448 E041 0.0000000       8 2127735 2127796 62 +      
ENSG00000036448 E042 1.2577119 0.415328714 3.614745e-01 5.058635e-01 8 2127797 2127881 85 + 0.443 0.247 -1.208
ENSG00000036448 E043 11.8572666 0.024971036 7.023472e-01 8.011848e-01 8 2129127 2129232 106 + 1.048 1.094 0.169
ENSG00000036448 E044 8.7228468 0.008721286 2.295929e-01 3.619544e-01 8 2140723 2140742 20 + 0.857 1.003 0.550
ENSG00000036448 E045 13.3371887 0.005991704 7.326588e-02 1.487403e-01 8 2140743 2140848 106 + 0.994 1.179 0.670
ENSG00000036448 E046 8.2476896 0.002134424 1.970847e-01 3.225807e-01 8 2140849 2140886 38 + 0.830 0.983 0.581
ENSG00000036448 E047 4.6557074 0.018505880 4.898793e-01 6.272530e-01 8 2141141 2141177 37 + 0.657 0.761 0.432
ENSG00000036448 E048 3.1185237 0.009856528 8.662784e-01 9.178986e-01 8 2142375 2142397 23 + 0.563 0.588 0.115
ENSG00000036448 E049 0.1482932 0.041364235 8.597354e-01   8 2143349 2143400 52 + 0.000 0.093 8.339
ENSG00000036448 E050 11.8338314 0.001859232 1.234044e-02 3.434999e-02 8 2143401 2143456 56 + 0.883 1.151 0.986
ENSG00000036448 E051 41.1523103 0.004059470 3.606745e-07 3.282351e-06 8 2144664 2145456 793 + 1.338 1.675 1.154
ENSG00000036448 E052 0.0000000       8 2165153 2165552 400 +