ENSG00000033030

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000538116 ENSG00000033030 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC8 protein_coding retained_intron 13.8428 6.714262 18.79524 0.2258043 0.226299 1.483687 6.319878 3.6023628 7.693952 0.26061444 0.4835052 1.0926559 0.48030000 0.53516667 0.40886667 -0.12630000 0.04217595 0.04217595 FALSE TRUE
ENST00000633063 ENSG00000033030 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC8 protein_coding protein_coding 13.8428 6.714262 18.79524 0.2258043 0.226299 1.483687 1.076123 0.7591907 1.400244 0.08830641 0.1143529 0.8745311 0.08647917 0.11280000 0.07446667 -0.03833333 0.22839329 0.04217595 FALSE TRUE
MSTRG.8213.6 ENSG00000033030 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC8 protein_coding   13.8428 6.714262 18.79524 0.2258043 0.226299 1.483687 3.131208 1.1617410 4.780245 0.04458184 0.3117427 2.0314457 0.20094167 0.17310000 0.25466667 0.08156667 0.09019515 0.04217595 FALSE TRUE
MSTRG.8213.7 ENSG00000033030 HEK293_OSMI2_2hA HEK293_TMG_2hB ZCCHC8 protein_coding   13.8428 6.714262 18.79524 0.2258043 0.226299 1.483687 1.580662 0.6567418 2.528155 0.14417734 0.1351273 1.9285800 0.10942083 0.09866667 0.13440000 0.03573333 0.50811242 0.04217595 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000033030 E001 0.0000000       12 122471599 122471599 1 -      
ENSG00000033030 E002 11.7506511 0.0015653163 8.727364e-03 0.0256043119 12 122471600 122472869 1270 - 0.968 1.239 0.979
ENSG00000033030 E003 1.8476635 0.0089338794 9.003575e-02 0.1751897798 12 122472870 122472892 23 - 0.309 0.609 1.565
ENSG00000033030 E004 246.0651761 0.0042857921 2.695825e-05 0.0001621681 12 122472893 122473939 1047 - 2.308 2.465 0.526
ENSG00000033030 E005 127.9006407 0.0008838312 4.826147e-01 0.6207517141 12 122473940 122474275 336 - 2.069 2.108 0.133
ENSG00000033030 E006 0.4751703 0.0208692891 1.898627e-01 0.3135902383 12 122477838 122477840 3 - 0.082 0.305 2.300
ENSG00000033030 E007 59.5799976 0.0004624754 7.091500e-01 0.8066185203 12 122477841 122477916 76 - 1.743 1.776 0.113
ENSG00000033030 E008 46.3910710 0.0005756637 6.647951e-01 0.7725683685 12 122477917 122477958 42 - 1.651 1.643 -0.028
ENSG00000033030 E009 54.2986511 0.0012670917 2.666693e-01 0.4049026689 12 122478206 122478292 87 - 1.730 1.686 -0.148
ENSG00000033030 E010 4.7411506 0.0134079431 4.656765e-01 0.6053356719 12 122478293 122478533 241 - 0.761 0.661 -0.413
ENSG00000033030 E011 67.0719803 0.0004223264 7.904101e-01 0.8659199845 12 122480190 122480311 122 - 1.805 1.809 0.012
ENSG00000033030 E012 1.2460731 0.1079476905 3.201964e-01 0.4632994212 12 122480312 122481422 1111 - 0.389 0.180 -1.492
ENSG00000033030 E013 69.6069103 0.0043709453 6.576513e-01 0.7669629121 12 122481522 122481664 143 - 1.823 1.814 -0.031
ENSG00000033030 E014 46.0916825 0.0069524628 2.715949e-01 0.4103696347 12 122481945 122481990 46 - 1.666 1.606 -0.205
ENSG00000033030 E015 37.6674966 0.0005798726 2.936851e-01 0.4347379365 12 122481991 122482001 11 - 1.576 1.528 -0.166
ENSG00000033030 E016 64.5350363 0.0003707135 9.354387e-01 0.9633715785 12 122482002 122482087 86 - 1.786 1.798 0.040
ENSG00000033030 E017 1.9500635 0.0076261607 7.272765e-01 0.8200647991 12 122482088 122482458 371 - 0.457 0.404 -0.282
ENSG00000033030 E018 52.5139568 0.0005412237 9.018393e-01 0.9414472764 12 122482635 122482695 61 - 1.695 1.717 0.074
ENSG00000033030 E019 10.6815006 0.0037853018 1.517384e-01 0.2640262539 12 122482696 122483278 583 - 1.086 0.938 -0.547
ENSG00000033030 E020 48.9575402 0.0004960831 7.854415e-02 0.1571557032 12 122483279 122483344 66 - 1.697 1.617 -0.272
ENSG00000033030 E021 7.3042984 0.0023832218 2.017836e-01 0.3284131939 12 122483345 122483459 115 - 0.938 0.786 -0.586
ENSG00000033030 E022 46.4165812 0.0006027012 2.852854e-02 0.0690716069 12 122483460 122483563 104 - 1.680 1.571 -0.369
ENSG00000033030 E023 8.8506381 0.0019281229 1.048399e-04 0.0005443602 12 122483564 122484162 599 - 1.079 0.551 -2.105
ENSG00000033030 E024 40.2408914 0.0005739196 2.459829e-01 0.3812449949 12 122489386 122489463 78 - 1.606 1.553 -0.182
ENSG00000033030 E025 42.4231324 0.0005798662 6.903034e-01 0.7920340162 12 122490462 122490567 106 - 1.613 1.606 -0.025
ENSG00000033030 E026 1.7090385 0.0094843041 1.011909e-01 0.1922928414 12 122490935 122491053 119 - 0.488 0.179 -2.020
ENSG00000033030 E027 36.8290049 0.0006233462 7.844615e-01 0.8617276287 12 122492715 122492789 75 - 1.554 1.553 -0.004
ENSG00000033030 E028 30.3099986 0.0007538757 1.527707e-01 0.2654300349 12 122498827 122498867 41 - 1.498 1.415 -0.284
ENSG00000033030 E029 19.9130935 0.0009708643 3.399404e-01 0.4838764908 12 122498868 122498869 2 - 1.316 1.252 -0.224
ENSG00000033030 E030 4.7989716 0.0974708563 4.611809e-01 0.6011748505 12 122498870 122499972 1103 - 0.692 0.824 0.529
ENSG00000033030 E031 4.7219440 0.0034280779 1.178546e-01 0.2168552947 12 122499973 122500595 623 - 0.656 0.883 0.913
ENSG00000033030 E032 0.8375349 0.3601822716 3.361525e-01 0.4799642053 12 122500640 122500641 2 - 0.150 0.406 1.902
ENSG00000033030 E033 63.1822862 0.0013215514 1.365642e-02 0.0374441834 12 122500642 122501248 607 - 1.813 1.704 -0.370