ENSG00000031823

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340578 ENSG00000031823 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP3 protein_coding protein_coding 73.57341 104.1303 53.61442 7.007071 3.176032 -0.9575669 29.726301 40.07208 21.214311 3.322946 0.67233135 -0.9172396 0.39627083 0.3843333 0.39870000 0.01436667 9.100353e-01 6.251597e-29 FALSE TRUE
ENST00000439268 ENSG00000031823 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP3 protein_coding protein_coding 73.57341 104.1303 53.61442 7.007071 3.176032 -0.9575669 5.331230 15.23258 0.000000 1.564857 0.00000000 -10.5738915 0.06652083 0.1499333 0.00000000 -0.14993333 6.251597e-29 6.251597e-29 FALSE TRUE
ENST00000587159 ENSG00000031823 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP3 protein_coding processed_transcript 73.57341 104.1303 53.61442 7.007071 3.176032 -0.9575669 6.316348 13.17705 2.220756 1.993456 1.20029377 -2.5635170 0.07405417 0.1251000 0.04106667 -0.08403333 4.881674e-01 6.251597e-29 FALSE FALSE
ENST00000591092 ENSG00000031823 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP3 protein_coding protein_coding 73.57341 104.1303 53.61442 7.007071 3.176032 -0.9575669 19.841966 21.64137 18.370637 3.963921 0.03246374 -0.2362715 0.28214583 0.2043667 0.34490000 0.14053333 1.579067e-02 6.251597e-29 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000031823 E001 2.2873462 0.0065008124 3.514110e-01 4.956355e-01 19 5912537 5912575 39 - 0.590 0.440 -0.721
ENSG00000031823 E002 21.8029530 0.0008605626 2.234302e-04 1.063843e-03 19 5912576 5913213 638 - 1.483 1.214 -0.936
ENSG00000031823 E003 1865.1582905 0.0018440512 2.993645e-10 4.873053e-09 19 5916139 5917315 1177 - 3.111 3.256 0.480
ENSG00000031823 E004 192.0610819 0.0005691211 5.128008e-02 1.114352e-01 19 5917316 5917321 6 - 2.184 2.253 0.228
ENSG00000031823 E005 171.3505065 0.0005832526 4.501357e-01 5.912885e-01 19 5917322 5917322 1 - 2.162 2.195 0.109
ENSG00000031823 E006 266.1409527 0.0002217266 2.616579e-01 3.993290e-01 19 5917323 5917351 29 - 2.349 2.385 0.121
ENSG00000031823 E007 504.8379491 0.0003302990 4.323589e-04 1.898857e-03 19 5917352 5917639 288 - 2.594 2.672 0.259
ENSG00000031823 E008 163.3592425 0.0002425856 9.385078e-03 2.724406e-02 19 5917640 5917653 14 - 2.093 2.185 0.306
ENSG00000031823 E009 637.1449183 0.0002932360 2.450923e-05 1.489957e-04 19 5917794 5917980 187 - 2.689 2.772 0.278
ENSG00000031823 E010 1.0266130 0.0121989077 4.313702e-01 5.739253e-01 19 5918403 5918495 93 - 0.171 0.322 1.186
ENSG00000031823 E011 801.8663963 0.0001389630 1.369774e-03 5.208319e-03 19 5918496 5918638 143 - 2.810 2.866 0.186
ENSG00000031823 E012 1.8821031 0.0406443287 1.602655e-02 4.279386e-02 19 5920892 5921200 309 - 0.000 0.506 13.895
ENSG00000031823 E013 700.8108975 0.0006616556 9.117677e-01 9.480228e-01 19 5921201 5921321 121 - 2.789 2.797 0.026
ENSG00000031823 E014 415.5717085 0.0005050466 4.592854e-01 5.994933e-01 19 5923194 5923214 21 - 2.574 2.567 -0.022
ENSG00000031823 E015 619.2672821 0.0018458859 1.697602e-01 2.878959e-01 19 5923215 5923303 89 - 2.760 2.735 -0.082
ENSG00000031823 E016 636.6130786 0.0009667890 1.838224e-03 6.721340e-03 19 5923812 5923914 103 - 2.793 2.738 -0.182
ENSG00000031823 E017 490.4544261 0.0001974517 5.360801e-03 1.691192e-02 19 5924827 5924905 79 - 2.670 2.628 -0.139
ENSG00000031823 E018 3.0224679 0.0072269350 4.226324e-01 5.657606e-01 19 5924906 5925633 728 - 0.467 0.610 0.671
ENSG00000031823 E019 291.7277094 0.0002004482 6.991902e-03 2.120336e-02 19 5925634 5925651 18 - 2.453 2.400 -0.178
ENSG00000031823 E020 273.9833909 0.0001684497 2.442801e-01 3.792312e-01 19 5925652 5925663 12 - 2.401 2.382 -0.064
ENSG00000031823 E021 432.7179924 0.0001319521 1.010096e-02 2.900989e-02 19 5925664 5925737 74 - 2.613 2.573 -0.133
ENSG00000031823 E022 1.5060351 0.0096765512 2.958814e-02 7.114966e-02 19 5925738 5925765 28 - 0.000 0.441 14.183
ENSG00000031823 E023 344.4316897 0.0001597886 1.243478e-02 3.458311e-02 19 5927968 5928015 48 - 2.517 2.473 -0.148
ENSG00000031823 E024 319.3799632 0.0004319394 7.213823e-02 1.468934e-01 19 5928016 5928061 46 - 2.476 2.443 -0.111
ENSG00000031823 E025 276.2946229 0.0004219422 5.039628e-02 1.098714e-01 19 5928062 5928087 26 - 2.417 2.377 -0.133
ENSG00000031823 E026 1.2040641 0.3507760554 5.307197e-01 6.632623e-01 19 5928088 5928279 192 - 0.171 0.365 1.448
ENSG00000031823 E027 0.3289534 0.0274424043 5.566376e-01   19 5928280 5928313 34 - 0.171 0.086 -1.135
ENSG00000031823 E028 0.3289534 0.0274424043 5.566376e-01   19 5928314 5928444 131 - 0.171 0.086 -1.135
ENSG00000031823 E029 122.8416673 0.0004212134 4.702644e-01 6.094679e-01 19 5931404 5931418 15 - 2.053 2.035 -0.058
ENSG00000031823 E030 276.2047720 0.0001919288 9.468766e-01 9.706553e-01 19 5931419 5931450 32 - 2.381 2.391 0.034
ENSG00000031823 E031 306.7874774 0.0004424910 1.167876e-01 2.153730e-01 19 5931451 5931495 45 - 2.399 2.446 0.158
ENSG00000031823 E032 229.1530032 0.0028085723 2.334159e-01 3.664565e-01 19 5931496 5931500 5 - 2.267 2.322 0.186
ENSG00000031823 E033 240.0750719 0.0013826192 9.686306e-01 9.843640e-01 19 5931501 5931512 12 - 2.319 2.330 0.038
ENSG00000031823 E034 268.3853518 0.0003703431 9.759274e-01 9.889866e-01 19 5931513 5931531 19 - 2.368 2.378 0.032
ENSG00000031823 E035 447.9052037 0.0001228723 3.545121e-01 4.988250e-01 19 5932452 5932544 93 - 2.606 2.597 -0.029
ENSG00000031823 E036 6.3717543 0.1063097152 3.719408e-01 5.164097e-01 19 5932545 5933318 774 - 0.942 0.757 -0.716
ENSG00000031823 E037 1.5468358 0.0663972499 8.763889e-01 9.246705e-01 19 5933412 5933413 2 - 0.389 0.366 -0.131
ENSG00000031823 E038 253.0951256 0.0006255822 2.343960e-02 5.865921e-02 19 5933414 5933416 3 - 2.391 2.340 -0.170
ENSG00000031823 E039 257.8957054 0.0002812815 8.002987e-03 2.378709e-02 19 5933417 5933419 3 - 2.403 2.346 -0.190
ENSG00000031823 E040 356.5287415 0.0001435863 1.311312e-01 2.357300e-01 19 5933420 5933473 54 - 2.518 2.495 -0.076
ENSG00000031823 E041 223.1921301 0.0002150384 1.286417e-01 2.322643e-01 19 5933474 5933479 6 - 2.322 2.290 -0.105
ENSG00000031823 E042 17.6417442 0.0031816281 6.458355e-01 7.579048e-01 19 5933480 5933656 177 - 1.176 1.227 0.180
ENSG00000031823 E043 13.4967143 0.0232443641 1.508642e-01 2.628501e-01 19 5933657 5933802 146 - 1.216 1.058 -0.567
ENSG00000031823 E044 16.8191932 0.0035458563 8.796155e-02 1.720160e-01 19 5933803 5933929 127 - 1.297 1.152 -0.511
ENSG00000031823 E045 39.7772029 0.0005841536 2.000932e-02 5.150695e-02 19 5933930 5934462 533 - 1.647 1.519 -0.437
ENSG00000031823 E046 8.9970189 0.1174440856 9.670045e-03 2.794967e-02 19 5935685 5935839 155 - 1.241 0.758 -1.796
ENSG00000031823 E047 340.0002636 0.0010990630 6.261526e-02 1.310488e-01 19 5941621 5941670 50 - 2.508 2.470 -0.128
ENSG00000031823 E048 296.0782504 0.0027263852 1.690386e-01 2.869393e-01 19 5941671 5941707 37 - 2.445 2.411 -0.116
ENSG00000031823 E049 276.9734452 0.0028845471 3.461892e-01 4.903478e-01 19 5941799 5941835 37 - 2.407 2.386 -0.071
ENSG00000031823 E050 0.4031496 0.0245429754 5.196460e-01 6.537160e-01 19 5950577 5950716 140 - 0.000 0.158 11.834
ENSG00000031823 E051 7.8601823 0.0024902516 9.480384e-01 9.713470e-01 19 5950717 5950872 156 - 0.889 0.905 0.058
ENSG00000031823 E052 0.7331471 0.0172671820 1.775487e-01 2.980607e-01 19 5950873 5950875 3 - 0.000 0.274 12.984
ENSG00000031823 E053 36.2967806 0.0270048152 3.726671e-01 5.170925e-01 19 5951393 5951596 204 - 1.440 1.544 0.358
ENSG00000031823 E054 0.9525186 0.0143351578 7.588083e-02 1.529184e-01 19 5957907 5957917 11 - 0.467 0.158 -2.135
ENSG00000031823 E055 231.0979431 0.0038562272 1.590059e-01 2.737974e-01 19 5957918 5957935 18 - 2.344 2.301 -0.146
ENSG00000031823 E056 236.7090378 0.0043698522 4.891864e-02 1.072365e-01 19 5957936 5957968 33 - 2.372 2.304 -0.226
ENSG00000031823 E057 188.9827394 0.0018287362 2.919054e-04 1.346791e-03 19 5957969 5957973 5 - 2.305 2.191 -0.380
ENSG00000031823 E058 0.5514428 0.0196701891 2.948925e-01 4.359971e-01 19 5965733 5965922 190 - 0.000 0.220 12.516
ENSG00000031823 E059 2.1025318 0.0067961359 6.565441e-01 7.660631e-01 19 5974350 5974431 82 - 0.389 0.474 0.450
ENSG00000031823 E060 2.1370744 0.4325493209 5.369240e-01 6.685886e-01 19 5976381 5976574 194 - 0.294 0.496 1.139
ENSG00000031823 E061 0.1817044 0.0392297159 1.000000e+00   19 5976575 5976579 5 - 0.000 0.086 10.605
ENSG00000031823 E062 227.8710593 0.0038896920 1.650836e-03 6.123747e-03 19 5978061 5978204 144 - 2.386 2.273 -0.375
ENSG00000031823 E063 4.2622219 0.0037906904 7.564606e-01 8.415349e-01 19 5978939 5980727 1789 - 0.641 0.695 0.228