ENSG00000031003

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000033079 ENSG00000031003 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM13B protein_coding protein_coding 9.351412 2.68995 16.45083 0.3188774 0.2420048 2.608032 2.9028261 1.2432858 4.2659504 0.16665512 1.13461092 1.770530 0.3807042 0.47276667 0.2604667 -0.21230000 2.527268e-01 4.764078e-10 FALSE TRUE
ENST00000513640 ENSG00000031003 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM13B protein_coding retained_intron 9.351412 2.68995 16.45083 0.3188774 0.2420048 2.608032 0.4337371 0.1194596 0.2742215 0.07204245 0.03804441 1.134514 0.0566750 0.03926667 0.0166000 -0.02266667 5.232727e-01 4.764078e-10   FALSE
ENST00000689681 ENSG00000031003 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM13B protein_coding protein_coding 9.351412 2.68995 16.45083 0.3188774 0.2420048 2.608032 3.5727667 1.1866819 7.3339766 0.27659455 1.23030125 2.617522 0.3608417 0.43613333 0.4445333 0.00840000 1.000000e+00 4.764078e-10 FALSE TRUE
MSTRG.26988.3 ENSG00000031003 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM13B protein_coding   9.351412 2.68995 16.45083 0.3188774 0.2420048 2.608032 2.1607525 0.0934014 4.1901707 0.05111362 0.17704238 5.344120 0.1665125 0.03390000 0.2545667 0.22066667 4.764078e-10 4.764078e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000031003 E001 389.9808952 0.0128892367 4.779482e-11 8.906733e-10 5 137937960 137939841 1882 - 2.360 2.751 1.301
ENSG00000031003 E002 111.9659226 0.0002913036 1.797457e-01 3.008419e-01 5 137939842 137940150 309 - 1.882 2.011 0.432
ENSG00000031003 E003 44.7034693 0.0005054875 9.286059e-01 9.590717e-01 5 137940151 137940171 21 - 1.501 1.576 0.258
ENSG00000031003 E004 40.1122089 0.0005588124 8.323579e-01 8.949563e-01 5 137940172 137940180 9 - 1.460 1.513 0.182
ENSG00000031003 E005 98.3410625 0.0002809024 1.974926e-01 3.230752e-01 5 137940181 137940348 168 - 1.827 1.957 0.436
ENSG00000031003 E006 73.7743793 0.0004033253 7.239285e-01 8.176290e-01 5 137941944 137942045 102 - 1.712 1.801 0.301
ENSG00000031003 E007 94.6854452 0.0003637292 8.339226e-01 8.960017e-01 5 137942875 137943038 164 - 1.820 1.900 0.270
ENSG00000031003 E008 58.0690762 0.0004987983 6.715909e-01 7.777805e-01 5 137943133 137943194 62 - 1.622 1.665 0.145
ENSG00000031003 E009 38.0041626 0.0007347772 6.511333e-01 7.620852e-01 5 137943195 137943216 22 - 1.433 1.535 0.351
ENSG00000031003 E010 61.3228400 0.0004852552 4.649008e-01 6.045846e-01 5 137945902 137945997 96 - 1.648 1.672 0.083
ENSG00000031003 E011 1.9124110 0.0077805295 2.485184e-02 6.156768e-02 5 137945998 137946227 230 - 0.272 0.721 2.294
ENSG00000031003 E012 31.9042579 0.0006479538 2.625297e-01 4.003209e-01 5 137946228 137946311 84 - 1.377 1.349 -0.100
ENSG00000031003 E013 1.5961310 0.0109747185 6.497816e-01 7.609188e-01 5 137946312 137946395 84 - 0.300 0.433 0.781
ENSG00000031003 E014 83.1192596 0.0008611731 4.102143e-03 1.343044e-02 5 137948955 137949184 230 - 1.791 1.696 -0.323
ENSG00000031003 E015 56.7800647 0.0004808876 1.550413e-01 2.684659e-01 5 137952628 137952709 82 - 1.619 1.595 -0.081
ENSG00000031003 E016 36.5031419 0.0005682582 7.339826e-01 8.250658e-01 5 137953336 137953345 10 - 1.423 1.465 0.145
ENSG00000031003 E017 69.4657324 0.0004411541 8.164889e-02 1.621347e-01 5 137953346 137953465 120 - 1.707 1.673 -0.116
ENSG00000031003 E018 81.2753175 0.0013272219 1.118017e-01 2.082023e-01 5 137954166 137954376 211 - 1.772 1.752 -0.067
ENSG00000031003 E019 0.4783925 0.0210579577 3.870117e-01 5.311720e-01 5 137954377 137954624 248 - 0.096 0.268 1.780
ENSG00000031003 E020 20.1103388 0.0049372640 2.949984e-01 4.361135e-01 5 137956477 137956542 66 - 1.191 1.140 -0.182
ENSG00000031003 E021 62.9560023 0.0003837121 6.126132e-05 3.376814e-04 5 137959616 137959763 148 - 1.684 1.477 -0.706
ENSG00000031003 E022 37.8858295 0.0005552611 1.375264e-03 5.226054e-03 5 137960166 137960214 49 - 1.471 1.257 -0.744
ENSG00000031003 E023 48.0107123 0.0004738503 4.445680e-02 9.921553e-02 5 137962405 137962469 65 - 1.555 1.477 -0.267
ENSG00000031003 E024 59.1255976 0.0003930631 2.433537e-03 8.562737e-03 5 137985257 137985389 133 - 1.650 1.513 -0.470
ENSG00000031003 E025 60.2130576 0.0009785662 5.580070e-04 2.377491e-03 5 137987461 137987616 156 - 1.662 1.490 -0.590
ENSG00000031003 E026 39.6848445 0.0006149876 2.065190e-03 7.426677e-03 5 137988274 137988315 42 - 1.490 1.296 -0.673
ENSG00000031003 E027 65.5562743 0.0004660460 2.311594e-04 1.096511e-03 5 138006990 138007147 158 - 1.699 1.524 -0.598
ENSG00000031003 E028 56.9191337 0.0005941309 1.601808e-05 1.015690e-04 5 138011008 138011149 142 - 1.648 1.396 -0.864
ENSG00000031003 E029 44.3687731 0.0082671893 3.944941e-02 9.001377e-02 5 138011768 138011889 122 - 1.527 1.412 -0.394
ENSG00000031003 E030 25.1802178 0.0008003255 3.499541e-01 4.941435e-01 5 138011890 138011945 56 - 1.279 1.257 -0.078
ENSG00000031003 E031 34.2232647 0.0177691758 4.864459e-01 6.241879e-01 5 138018302 138018385 84 - 1.402 1.400 -0.004
ENSG00000031003 E032 28.3674580 0.0127639555 8.727110e-01 9.221408e-01 5 138018386 138018408 23 - 1.315 1.368 0.185
ENSG00000031003 E033 43.3166194 0.0005441660 3.403973e-01 4.843567e-01 5 138018409 138018478 70 - 1.502 1.501 -0.004
ENSG00000031003 E034 33.1794422 0.0006248933 1.563098e-01 2.702109e-01 5 138018479 138018514 36 - 1.402 1.349 -0.184
ENSG00000031003 E035 44.2161982 0.0009390110 5.660602e-01 6.930788e-01 5 138018955 138019146 192 - 1.507 1.535 0.094
ENSG00000031003 E036 0.8814178 0.4256530735 6.057069e-01 7.260570e-01 5 138019881 138019977 97 - 0.241 0.001 -8.300
ENSG00000031003 E037 2.1067783 0.0074631301 3.902379e-01 5.342282e-01 5 138020763 138021030 268 - 0.417 0.268 -0.921
ENSG00000031003 E038 52.6247425 0.0004259265 1.251937e-03 4.816140e-03 5 138021031 138021197 167 - 1.606 1.438 -0.574
ENSG00000031003 E039 55.6106057 0.0047636930 5.356643e-03 1.690094e-02 5 138032782 138033086 305 - 1.626 1.478 -0.503
ENSG00000031003 E040 0.0000000       5 138033773 138033869 97 -      
ENSG00000031003 E041 0.0000000       5 138034001 138034073 73 -      
ENSG00000031003 E042 0.0000000       5 138038566 138038606 41 -      
ENSG00000031003 E043 0.0000000       5 138051878 138051961 84 -