ENSG00000030066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378460 ENSG00000030066 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP160 protein_coding protein_coding 37.25305 12.98341 56.89292 0.681218 1.485152 2.130723 29.508386 10.9190801 44.109461 0.8654495 1.5010567 2.013243 0.8027708 0.83910000 0.77530000 -0.06380000 4.106926e-01 1.371431e-05 FALSE  
ENST00000694867 ENSG00000030066 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP160 protein_coding protein_coding 37.25305 12.98341 56.89292 0.681218 1.485152 2.130723 1.069711 1.1508998 1.416610 0.2521676 0.1067839 0.297348 0.0425375 0.08806667 0.02483333 -0.06323333 1.371431e-05 1.371431e-05 FALSE  
MSTRG.5498.4 ENSG00000030066 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP160 protein_coding   37.25305 12.98341 56.89292 0.681218 1.485152 2.130723 2.605273 0.2073313 4.296651 0.1185336 0.4685029 4.308599 0.0500750 0.01596667 0.07590000 0.05993333 6.383096e-02 1.371431e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000030066 E001 0.1472490 0.0437319562 1.000000e+00   11 47778087 47778117 31 - 0.063 0.000 -9.161
ENSG00000030066 E002 28.6641667 0.0188688656 1.495020e-12 3.559470e-11 11 47778118 47778236 119 - 1.125 1.831 2.436
ENSG00000030066 E003 192.2765678 0.0165017459 4.906318e-08 5.299243e-07 11 47778237 47778429 193 - 2.076 2.490 1.383
ENSG00000030066 E004 798.1479151 0.0087155977 5.601411e-12 1.214432e-10 11 47778430 47779164 735 - 2.718 3.064 1.148
ENSG00000030066 E005 223.0629248 0.0054211307 7.066014e-05 3.832995e-04 11 47779165 47779194 30 - 2.212 2.428 0.722
ENSG00000030066 E006 278.0176419 0.0038338215 5.074024e-07 4.483692e-06 11 47780343 47780447 105 - 2.302 2.532 0.767
ENSG00000030066 E007 273.3208564 0.0001557237 3.427492e-06 2.533842e-05 11 47783073 47783195 123 - 2.318 2.475 0.526
ENSG00000030066 E008 106.2619704 0.0002989454 1.166065e-01 2.151166e-01 11 47783196 47783198 3 - 1.925 2.030 0.355
ENSG00000030066 E009 2.5808913 0.0067205173 3.551016e-01 4.994576e-01 11 47784664 47784921 258 - 0.525 0.372 -0.793
ENSG00000030066 E010 254.4743356 0.0001891221 8.776594e-04 3.535928e-03 11 47784922 47785063 142 - 2.296 2.425 0.432
ENSG00000030066 E011 202.6573985 0.0002472208 2.137415e-05 1.316275e-04 11 47786453 47786554 102 - 2.188 2.353 0.552
ENSG00000030066 E012 1.1050531 0.0117768344 6.923715e-01 7.936378e-01 11 47786989 47787079 91 - 0.287 0.225 -0.470
ENSG00000030066 E013 234.6104572 0.0002103755 1.895561e-05 1.182172e-04 11 47788182 47788305 124 - 2.253 2.411 0.526
ENSG00000030066 E014 233.4959587 0.0001878727 3.758780e-02 8.656152e-02 11 47788501 47788611 111 - 2.266 2.366 0.333
ENSG00000030066 E015 172.9854338 0.0009368817 7.650210e-01 8.479064e-01 11 47791930 47791990 61 - 2.148 2.200 0.176
ENSG00000030066 E016 26.9971973 0.0007691031 8.234002e-01 8.887159e-01 11 47792012 47792785 774 - 1.357 1.416 0.204
ENSG00000030066 E017 325.1486952 0.0029339524 4.529908e-01 5.937917e-01 11 47792786 47792946 161 - 2.429 2.447 0.059
ENSG00000030066 E018 274.9000910 0.0022086918 9.160770e-01 9.509430e-01 11 47797779 47797884 106 - 2.352 2.394 0.140
ENSG00000030066 E019 247.8451427 0.0002551373 9.947623e-01 1.000000e+00 11 47797978 47798074 97 - 2.306 2.349 0.143
ENSG00000030066 E020 259.4880463 0.0001826139 8.242537e-01 8.892809e-01 11 47798168 47798262 95 - 2.327 2.364 0.123
ENSG00000030066 E021 234.9567250 0.0040970583 6.159600e-01 7.341044e-01 11 47798368 47798463 96 - 2.286 2.307 0.069
ENSG00000030066 E022 247.5040613 0.0001680386 9.081590e-01 9.456876e-01 11 47801811 47801930 120 - 2.305 2.344 0.132
ENSG00000030066 E023 0.4439371 0.0215601224 6.041870e-01 7.248078e-01 11 47803437 47803437 1 - 0.167 0.000 -10.696
ENSG00000030066 E024 229.7892095 0.0001665865 6.924660e-01 7.937125e-01 11 47803438 47803536 99 - 2.275 2.307 0.106
ENSG00000030066 E025 0.3666179 0.0348838018 3.163386e-01 4.590954e-01 11 47804296 47804353 58 - 0.063 0.225 2.117
ENSG00000030066 E026 1.4716710 0.0392523362 8.764760e-01 9.247317e-01 11 47804354 47804548 195 - 0.321 0.373 0.315
ENSG00000030066 E027 196.2187995 0.0002103455 9.256006e-03 2.692342e-02 11 47804549 47804618 70 - 2.221 2.182 -0.133
ENSG00000030066 E028 258.9702689 0.0003995145 1.242915e-01 2.261167e-01 11 47806153 47806312 160 - 2.332 2.331 -0.004
ENSG00000030066 E029 8.2662221 0.0032844531 1.934820e-03 7.024105e-03 11 47806313 47806515 203 - 0.961 0.482 -2.002
ENSG00000030066 E030 149.9540802 0.0004152817 2.728182e-01 4.117760e-01 11 47807070 47807140 71 - 2.096 2.099 0.009
ENSG00000030066 E031 179.4585193 0.0001810801 6.828932e-02 1.405393e-01 11 47808396 47808482 87 - 2.179 2.162 -0.056
ENSG00000030066 E032 138.5562554 0.0002548131 1.001677e-02 2.880460e-02 11 47808483 47808529 47 - 2.074 2.019 -0.184
ENSG00000030066 E033 236.1461358 0.0002767918 1.837588e-03 6.719663e-03 11 47812064 47812224 161 - 2.302 2.253 -0.165
ENSG00000030066 E034 1.1951715 0.0726344270 1.355317e-01 2.418574e-01 11 47812225 47812301 77 - 0.353 0.000 -12.114
ENSG00000030066 E035 226.5043221 0.0058628720 6.295652e-02 1.316386e-01 11 47812302 47812429 128 - 2.284 2.234 -0.168
ENSG00000030066 E036 234.9551889 0.0032722041 1.848812e-02 4.820555e-02 11 47812882 47813047 166 - 2.301 2.247 -0.182
ENSG00000030066 E037 189.4961379 0.0001985704 1.849211e-04 8.988980e-04 11 47813316 47813415 100 - 2.214 2.135 -0.267
ENSG00000030066 E038 0.4482035 0.0290243528 6.061027e-01 7.263410e-01 11 47815091 47815478 388 - 0.167 0.000 -10.697
ENSG00000030066 E039 238.5197184 0.0026380399 2.815652e-04 1.304804e-03 11 47815479 47815649 171 - 2.317 2.219 -0.327
ENSG00000030066 E040 191.5951453 0.0005480079 5.169571e-07 4.559403e-06 11 47815946 47816029 84 - 2.230 2.099 -0.438
ENSG00000030066 E041 189.6283843 0.0020495725 5.959545e-07 5.194708e-06 11 47818056 47818124 69 - 2.229 2.069 -0.535
ENSG00000030066 E042 205.6436869 0.0045971156 1.726276e-04 8.465243e-04 11 47819374 47819458 85 - 2.259 2.128 -0.440
ENSG00000030066 E043 3.6570402 0.0214417086 3.434174e-01 4.874567e-01 11 47821376 47821723 348 - 0.632 0.482 -0.693
ENSG00000030066 E044 214.1426035 0.0002581180 4.333669e-10 6.863980e-09 11 47821724 47821821 98 - 2.281 2.122 -0.532
ENSG00000030066 E045 169.0812190 0.0014930925 5.830681e-08 6.193815e-07 11 47822087 47822164 78 - 2.182 2.002 -0.602
ENSG00000030066 E046 0.2987644 0.0273155971 1.000000e+00   11 47822165 47822167 3 - 0.118 0.000 -10.112
ENSG00000030066 E047 1.7862559 0.0128012434 7.456765e-01 8.336550e-01 11 47827075 47827194 120 - 0.409 0.371 -0.211
ENSG00000030066 E048 239.1099283 0.0002919449 1.568901e-13 4.338396e-12 11 47835651 47835809 159 - 2.333 2.145 -0.628
ENSG00000030066 E049 201.8756042 0.0009763780 6.541667e-13 1.655932e-11 11 47836887 47837001 115 - 2.266 2.041 -0.750
ENSG00000030066 E050 159.7593191 0.0028195264 7.448683e-07 6.360742e-06 11 47837545 47837623 79 - 2.159 1.975 -0.616
ENSG00000030066 E051 23.5725041 0.0371918857 1.602619e-10 2.731301e-09 11 47839501 47839842 342 - 0.975 1.791 2.849
ENSG00000030066 E052 214.3352739 0.0003415067 1.081157e-04 5.594089e-04 11 47839843 47839945 103 - 2.268 2.189 -0.264
ENSG00000030066 E053 205.8434689 0.0003516168 2.985433e-05 1.777596e-04 11 47839946 47840065 120 - 2.252 2.160 -0.309
ENSG00000030066 E054 11.3695014 0.0175030882 1.271901e-03 4.883324e-03 11 47840066 47840377 312 - 0.888 1.300 1.494
ENSG00000030066 E055 324.3460734 0.0001381398 1.125683e-17 5.487836e-16 11 47840378 47840588 211 - 2.464 2.281 -0.609
ENSG00000030066 E056 247.3217633 0.0002181251 1.495639e-16 6.302142e-15 11 47847848 47847959 112 - 2.351 2.139 -0.708
ENSG00000030066 E057 161.3258102 0.0050036637 5.195430e-04 2.232993e-03 11 47848219 47848555 337 - 2.153 2.016 -0.461