ENSG00000029725

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341923 ENSG00000029725 HEK293_OSMI2_2hA HEK293_TMG_2hB RABEP1 protein_coding protein_coding 24.76879 15.00859 36.37526 0.3285636 0.7701393 1.276605 1.288045 0.87090998 1.258257 0.46070645 0.1156680 0.52578013 0.05465833 0.057133333 0.03470000 -0.02243333 1.000000e+00 1.067653e-23 FALSE TRUE
ENST00000537505 ENSG00000029725 HEK293_OSMI2_2hA HEK293_TMG_2hB RABEP1 protein_coding protein_coding 24.76879 15.00859 36.37526 0.3285636 0.7701393 1.276605 13.626891 5.24435000 21.254630 0.80310104 0.7741905 2.01687157 0.52847083 0.352000000 0.58510000 0.23310000 3.198831e-02 1.067653e-23 FALSE TRUE
ENST00000572250 ENSG00000029725 HEK293_OSMI2_2hA HEK293_TMG_2hB RABEP1 protein_coding protein_coding 24.76879 15.00859 36.37526 0.3285636 0.7701393 1.276605 1.253223 0.21447895 1.705413 0.07325079 0.4309035 2.93390364 0.05207500 0.014466667 0.04680000 0.03233333 6.563835e-02 1.067653e-23 FALSE FALSE
ENST00000575475 ENSG00000029725 HEK293_OSMI2_2hA HEK293_TMG_2hB RABEP1 protein_coding retained_intron 24.76879 15.00859 36.37526 0.3285636 0.7701393 1.276605 1.424512 0.05431502 3.467222 0.01075514 1.0551876 5.75663580 0.04425417 0.003566667 0.09453333 0.09096667 3.814984e-05 1.067653e-23 FALSE TRUE
MSTRG.13506.4 ENSG00000029725 HEK293_OSMI2_2hA HEK293_TMG_2hB RABEP1 protein_coding   24.76879 15.00859 36.37526 0.3285636 0.7701393 1.276605 5.468375 6.93242786 6.507104 0.29934625 0.3164933 -0.09120933 0.25013750 0.461533333 0.17886667 -0.28266667 1.067653e-23 1.067653e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000029725 E001 0.7352129 0.1084354307 8.115669e-01 8.804166e-01 17 5282265 5282283 19 + 0.237 0.198 -0.329
ENSG00000029725 E002 13.7342298 0.0013023442 5.147198e-02 1.117681e-01 17 5282284 5282298 15 + 1.166 0.988 -0.643
ENSG00000029725 E003 29.8586797 0.0079328339 2.213329e-01 3.520268e-01 17 5282299 5282321 23 + 1.457 1.387 -0.244
ENSG00000029725 E004 80.8682721 0.0104974639 7.721217e-01 8.529149e-01 17 5282322 5282486 165 + 1.849 1.903 0.182
ENSG00000029725 E005 62.3893638 0.0004035622 8.669458e-02 1.701126e-01 17 5282487 5282520 34 + 1.718 1.836 0.397
ENSG00000029725 E006 0.3666179 0.0306985647 4.271018e-01 5.699393e-01 17 5283884 5283982 99 + 0.073 0.200 1.682
ENSG00000029725 E007 0.5117906 0.2258990492 7.234740e-01 8.172976e-01 17 5283983 5284069 87 + 0.134 0.202 0.705
ENSG00000029725 E008 0.4460135 0.0304012745 4.266143e-01 5.694252e-01 17 5297489 5297514 26 + 0.189 0.001 -8.545
ENSG00000029725 E009 159.2746273 0.0002273064 1.324942e-05 8.555088e-05 17 5308694 5308822 129 + 2.102 2.269 0.557
ENSG00000029725 E010 231.7937920 0.0002205764 1.705048e-11 3.417438e-10 17 5331949 5332054 106 + 2.252 2.455 0.676
ENSG00000029725 E011 250.9714177 0.0003074795 3.558744e-12 7.975789e-11 17 5332055 5332152 98 + 2.288 2.492 0.681
ENSG00000029725 E012 277.0068761 0.0002638977 1.162679e-16 4.955366e-15 17 5335184 5335344 161 + 2.322 2.547 0.749
ENSG00000029725 E013 19.9537614 0.0187662342 2.620237e-13 7.024140e-12 17 5336488 5336689 202 + 0.908 1.686 2.746
ENSG00000029725 E014 188.5551395 0.0026030582 2.380050e-03 8.398401e-03 17 5338019 5338138 120 + 2.184 2.328 0.480
ENSG00000029725 E015 149.2894819 0.0297456499 5.914826e-04 2.502280e-03 17 5346790 5346925 136 + 2.185 1.913 -0.912
ENSG00000029725 E016 81.7305146 0.0010008173 2.969068e-12 6.745995e-11 17 5350451 5350471 21 + 1.935 1.603 -1.124
ENSG00000029725 E017 177.2669802 0.0061796120 4.935681e-10 7.734077e-09 17 5350472 5350629 158 + 2.262 1.975 -0.958
ENSG00000029725 E018 107.3106029 0.0003229870 3.044791e-11 5.857297e-10 17 5354359 5354400 42 + 2.040 1.789 -0.842
ENSG00000029725 E019 127.8627614 0.0013906407 3.265772e-10 5.281635e-09 17 5354401 5354490 90 + 2.112 1.879 -0.785
ENSG00000029725 E020 0.5212538 0.0202537569 1.353366e-01 2.415867e-01 17 5356508 5356573 66 + 0.073 0.335 2.679
ENSG00000029725 E021 195.7261076 0.0002212091 1.490448e-16 6.281665e-15 17 5361208 5361438 231 + 2.295 2.070 -0.751
ENSG00000029725 E022 195.8712659 0.0002137480 1.351740e-12 3.241969e-11 17 5361439 5361675 237 + 2.288 2.105 -0.612
ENSG00000029725 E023 149.3306221 0.0002736538 5.915023e-07 5.159699e-06 17 5362912 5363016 105 + 2.163 2.025 -0.462
ENSG00000029725 E024 168.6836468 0.0027516529 3.139666e-04 1.436646e-03 17 5365122 5365238 117 + 2.208 2.096 -0.376
ENSG00000029725 E025 143.3868433 0.0060814408 1.157359e-02 3.252219e-02 17 5368370 5368468 99 + 2.133 2.037 -0.323
ENSG00000029725 E026 174.3803443 0.0004700294 5.417014e-05 3.025909e-04 17 5373314 5373454 141 + 2.219 2.123 -0.321
ENSG00000029725 E027 123.7752129 0.0002406980 5.842719e-04 2.475645e-03 17 5377116 5377210 95 + 2.070 1.977 -0.312
ENSG00000029725 E028 108.7283652 0.0002959791 9.443146e-04 3.769200e-03 17 5377211 5377305 95 + 2.014 1.917 -0.326
ENSG00000029725 E029 85.8056836 0.0003150406 6.706151e-02 1.384788e-01 17 5378177 5378232 56 + 1.900 1.854 -0.153
ENSG00000029725 E030 1.1801942 0.0123100814 9.811304e-01 9.922339e-01 17 5378233 5378693 461 + 0.320 0.335 0.092
ENSG00000029725 E031 107.1977847 0.0002926495 6.193518e-02 1.298765e-01 17 5380364 5380462 99 + 1.993 1.955 -0.129
ENSG00000029725 E032 146.2821882 0.0003774628 4.381513e-03 1.421027e-02 17 5381389 5381505 117 + 2.133 2.070 -0.212
ENSG00000029725 E033 6.6461772 0.0025520740 3.026699e-01 4.445741e-01 17 5381506 5381721 216 + 0.867 0.753 -0.450
ENSG00000029725 E034 1159.0511756 0.0071226018 1.467214e-05 9.381640e-05 17 5383122 5386340 3219 + 2.959 3.137 0.594