ENSG00000029534

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265709 ENSG00000029534 HEK293_OSMI2_2hA HEK293_TMG_2hB ANK1 protein_coding protein_coding 0.7285934 1.521342 0.5939416 0.155487 0.08596399 -1.342315 0.043014891 0.05590156 0.08254013 0.05590156 0.01331176 0.4897664 0.09199167 0.0407000 0.1387 0.09800000 0.2596885181 0.0001176829 FALSE TRUE
ENST00000289734 ENSG00000029534 HEK293_OSMI2_2hA HEK293_TMG_2hB ANK1 protein_coding protein_coding 0.7285934 1.521342 0.5939416 0.155487 0.08596399 -1.342315 0.067132440 0.37546724 0.00000000 0.06615190 0.00000000 -5.2685363 0.05148333 0.2452333 0.0000 -0.24523333 0.0001176829 0.0001176829 FALSE TRUE
ENST00000347528 ENSG00000029534 HEK293_OSMI2_2hA HEK293_TMG_2hB ANK1 protein_coding protein_coding 0.7285934 1.521342 0.5939416 0.155487 0.08596399 -1.342315 0.350004894 0.52934569 0.26859329 0.03452304 0.01188552 -0.9530498 0.51807917 0.3553000 0.4737 0.11840000 0.6353488467 0.0001176829 FALSE TRUE
ENST00000520299 ENSG00000029534 HEK293_OSMI2_2hA HEK293_TMG_2hB ANK1 protein_coding protein_coding 0.7285934 1.521342 0.5939416 0.155487 0.08596399 -1.342315 0.004599618 0.00000000 0.03679694 0.00000000 0.03679694 2.2264142 0.00978750 0.0000000 0.0783 0.07830000 0.6358023421 0.0001176829 FALSE TRUE
ENST00000645531 ENSG00000029534 HEK293_OSMI2_2hA HEK293_TMG_2hB ANK1 protein_coding protein_coding 0.7285934 1.521342 0.5939416 0.155487 0.08596399 -1.342315 0.248926651 0.51766347 0.20601128 0.10906502 0.11237764 -1.2885115 0.30473333 0.3353333 0.3093 -0.02603333 0.9336174168 0.0001176829 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000029534 E001 0.0000000       8 41653220 41653224 5 -      
ENSG00000029534 E002 48.4875538 0.008392287 0.0006493907 0.002713809 8 41653225 41655300 2076 - 1.409 1.662 0.867
ENSG00000029534 E003 2.5097338 0.010088872 0.5880089310 0.711253530 8 41655301 41655323 23 - 0.422 0.521 0.499
ENSG00000029534 E004 3.9803686 0.005327573 0.1569062402 0.270975009 8 41655324 41655374 51 - 0.422 0.671 1.166
ENSG00000029534 E005 5.0016961 0.003423729 0.0431858041 0.096888054 8 41655375 41655439 65 - 0.422 0.767 1.561
ENSG00000029534 E006 16.5016760 0.001260091 0.0095262353 0.027603076 8 41655440 41655685 246 - 0.937 1.212 0.999
ENSG00000029534 E007 7.0572020 0.002720491 0.5959872413 0.717983905 8 41655686 41655753 68 - 0.773 0.846 0.287
ENSG00000029534 E008 0.0000000       8 41660989 41661429 441 -      
ENSG00000029534 E009 0.5117019 0.022890144 0.4004560746 0.544160339 8 41661430 41661526 97 - 0.000 0.199 11.310
ENSG00000029534 E010 0.0000000       8 41661527 41661564 38 -      
ENSG00000029534 E011 0.0000000       8 41661565 41661800 236 -      
ENSG00000029534 E012 2.2004751 0.006603055 0.8020890095 0.873916252 8 41661801 41661875 75 - 0.422 0.468 0.238
ENSG00000029534 E013 4.5192433 0.003857781 0.3434128468 0.487453985 8 41661876 41661941 66 - 0.773 0.633 -0.579
ENSG00000029534 E014 7.2524245 0.002385113 0.7893710109 0.865176166 8 41663659 41663742 84 - 0.879 0.845 -0.129
ENSG00000029534 E015 0.0000000       8 41664805 41664909 105 -      
ENSG00000029534 E016 0.0000000       8 41664910 41665207 298 -      
ENSG00000029534 E017 0.0000000       8 41665208 41665261 54 -      
ENSG00000029534 E018 0.0000000       8 41665262 41665274 13 -      
ENSG00000029534 E019 0.0000000       8 41665275 41665286 12 -      
ENSG00000029534 E020 0.0000000       8 41665533 41665830 298 -      
ENSG00000029534 E021 9.2473464 0.001955785 0.5091166686 0.644460651 8 41668267 41668340 74 - 0.879 0.960 0.309
ENSG00000029534 E022 15.7527329 0.016230436 0.9200803827 0.953515614 8 41668341 41668564 224 - 1.166 1.159 -0.027
ENSG00000029534 E023 9.2170609 0.002764728 0.1956961610 0.320829120 8 41672354 41672426 73 - 1.057 0.911 -0.538
ENSG00000029534 E024 6.6436200 0.007423670 0.2430057068 0.377724646 8 41672427 41672515 89 - 0.684 0.856 0.691
ENSG00000029534 E025 3.3589088 0.019181528 0.5452033574 0.675595982 8 41672516 41672529 14 - 0.504 0.611 0.496
ENSG00000029534 E026 10.0506123 0.001912133 0.5627184085 0.690279040 8 41672530 41672912 383 - 0.909 0.979 0.262
ENSG00000029534 E027 11.2139565 0.001697767 0.2674461265 0.405763417 8 41684544 41684690 147 - 1.096 0.979 -0.430
ENSG00000029534 E028 9.5825399 0.027906280 0.8460643505 0.904284079 8 41686152 41686283 132 - 0.964 0.938 -0.096
ENSG00000029534 E029 6.8744535 0.002720795 0.9433567569 0.968471582 8 41688156 41688230 75 - 0.811 0.821 0.039
ENSG00000029534 E030 7.3946511 0.011417283 0.3288750580 0.472364409 8 41688511 41688589 79 - 0.937 0.810 -0.489
ENSG00000029534 E031 6.7742079 0.002706566 0.5188317865 0.652980033 8 41690227 41690285 59 - 0.879 0.795 -0.327
ENSG00000029534 E032 6.2582501 0.003809852 0.6563425567 0.765964791 8 41690286 41690346 61 - 0.730 0.795 0.259
ENSG00000029534 E033 7.7916467 0.004793895 0.5541282514 0.683138770 8 41690474 41690599 126 - 0.811 0.891 0.309
ENSG00000029534 E034 8.4023255 0.002420387 0.9886563857 0.996965882 8 41692648 41692876 229 - 0.909 0.912 0.010
ENSG00000029534 E035 5.1584970 0.003367678 0.2574159999 0.394530155 8 41693105 41693201 97 - 0.572 0.752 0.766
ENSG00000029534 E036 3.5396563 0.004606917 0.9088873386 0.946122959 8 41693898 41693929 32 - 0.572 0.592 0.088
ENSG00000029534 E037 8.0518032 0.004755411 0.8114896920 0.880378843 8 41693930 41694102 173 - 0.909 0.880 -0.111
ENSG00000029534 E038 7.9714823 0.002523652 0.0200826932 0.051662833 8 41694592 41694803 212 - 1.077 0.808 -1.013
ENSG00000029534 E039 6.2227797 0.002676860 0.1204181038 0.220565301 8 41695177 41695331 155 - 0.937 0.737 -0.782
ENSG00000029534 E040 8.0242684 0.002122824 0.8101483790 0.879511622 8 41696363 41696587 225 - 0.909 0.880 -0.111
ENSG00000029534 E041 7.0173500 0.003569389 0.4287804623 0.571501667 8 41696676 41696773 98 - 0.909 0.808 -0.390
ENSG00000029534 E042 0.0000000       8 41697727 41697846 120 -      
ENSG00000029534 E043 5.7567186 0.049155645 0.6291211083 0.744553253 8 41698043 41698121 79 - 0.811 0.741 -0.277
ENSG00000029534 E044 9.0736210 0.046049685 0.6939617707 0.794893197 8 41699452 41699548 97 - 0.879 0.951 0.273
ENSG00000029534 E045 0.0000000       8 41700431 41700454 24 -      
ENSG00000029534 E046 7.3450954 0.027903377 0.9247217069 0.956598738 8 41701550 41701622 73 - 0.846 0.866 0.078
ENSG00000029534 E047 5.5490045 0.005963361 0.3656583203 0.509978075 8 41702052 41702144 93 - 0.846 0.721 -0.498
ENSG00000029534 E048 4.2705512 0.004176826 0.0844548749 0.166533674 8 41704041 41704139 99 - 0.422 0.721 1.375
ENSG00000029534 E049 3.7943514 0.030167075 0.6700482097 0.776632635 8 41704374 41704472 99 - 0.572 0.649 0.338
ENSG00000029534 E050 2.3271001 0.006750123 0.1794783125 0.300479223 8 41706143 41706179 37 - 0.632 0.406 -1.083
ENSG00000029534 E051 4.0662232 0.004274096 0.2252908625 0.356763418 8 41706180 41706241 62 - 0.773 0.592 -0.761
ENSG00000029534 E052 5.8614593 0.003554866 0.2891545168 0.429829990 8 41708778 41708975 198 - 0.879 0.737 -0.560
ENSG00000029534 E053 3.7536143 0.070100229 0.9260036815 0.957407342 8 41714156 41714254 99 - 0.631 0.612 -0.081
ENSG00000029534 E054 3.5471318 0.032401173 0.7216648362 0.815954392 8 41714976 41715074 99 - 0.632 0.572 -0.267
ENSG00000029534 E055 6.0933973 0.011355058 0.6706134148 0.777014156 8 41715652 41715849 198 - 0.731 0.795 0.258
ENSG00000029534 E056 3.3128148 0.100023099 0.3124048446 0.454951307 8 41716953 41717051 99 - 0.730 0.538 -0.831
ENSG00000029534 E057 4.3613005 0.029514092 0.0640181399 0.133380747 8 41717604 41717702 99 - 0.878 0.591 -1.179
ENSG00000029534 E058 5.2782164 0.095333107 0.1236109951 0.225103180 8 41718106 41718204 99 - 0.937 0.653 -1.129
ENSG00000029534 E059 8.7182420 0.150474914 0.7454292580 0.833469854 8 41719661 41719858 198 - 0.987 0.900 -0.328
ENSG00000029534 E060 4.9471961 0.062167425 0.7802905815 0.858796076 8 41723125 41723223 99 - 0.683 0.721 0.157
ENSG00000029534 E061 4.1494006 0.003993120 0.1266786037 0.229522584 8 41723535 41723633 99 - 0.422 0.688 1.240
ENSG00000029534 E062 3.4172856 0.007174500 0.6092998183 0.728816913 8 41724456 41724554 99 - 0.503 0.592 0.411
ENSG00000029534 E063 4.6383902 0.008584779 0.9296436078 0.959683259 8 41725761 41725946 186 - 0.684 0.671 -0.053
ENSG00000029534 E064 3.0476766 0.069529384 0.1393145182 0.247113568 8 41727250 41727348 99 - 0.730 0.471 -1.162
ENSG00000029534 E065 3.3902474 0.009915509 0.0387372063 0.088694209 8 41727908 41728006 99 - 0.811 0.495 -1.362
ENSG00000029534 E066 3.4017738 0.074764737 0.1651471451 0.281881858 8 41733971 41734069 99 - 0.773 0.519 -1.099
ENSG00000029534 E067 2.9505635 0.005428614 0.2401306353 0.374294541 8 41758036 41758137 102 - 0.684 0.495 -0.847
ENSG00000029534 E068 0.0000000       8 41788882 41789297 416 -      
ENSG00000029534 E069 0.9148515 0.015185717 0.1690763383 0.286987887 8 41797512 41797593 82 - 0.000 0.294 12.013
ENSG00000029534 E070 0.7331471 0.017267182 0.2548587187 0.391646818 8 41797594 41797622 29 - 0.000 0.249 11.708
ENSG00000029534 E071 0.4375944 0.024309927 0.0091168870 0.026575887 8 41896355 41896762 408 - 0.422 0.000 -14.510