ENSG00000029364

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000031146 ENSG00000029364 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A9 protein_coding protein_coding 21.82334 15.90901 24.76355 4.414164 0.3124016 0.6380495 3.555947 5.3894610 3.0144381 2.6304677 0.1577641 -0.83614824 0.16355833 0.32986667 0.12180000 -0.20806667 1.980019e-01 4.503716e-12 FALSE TRUE
ENST00000336643 ENSG00000029364 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A9 protein_coding protein_coding 21.82334 15.90901 24.76355 4.414164 0.3124016 0.6380495 12.112678 4.4767078 15.1381941 1.8755568 0.4290497 1.75541667 0.54910000 0.29466667 0.61193333 0.31726667 9.387557e-02 4.503716e-12 FALSE TRUE
MSTRG.9805.11 ENSG00000029364 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A9 protein_coding   21.82334 15.90901 24.76355 4.414164 0.3124016 0.6380495 1.602718 4.0650148 0.3374412 1.8247982 0.0470943 -3.55196446 0.08598333 0.24123333 0.01366667 -0.22756667 4.503716e-12 4.503716e-12 FALSE TRUE
MSTRG.9805.12 ENSG00000029364 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC39A9 protein_coding   21.82334 15.90901 24.76355 4.414164 0.3124016 0.6380495 1.003692 0.6777697 0.6540199 0.2429417 0.2515200 -0.05069921 0.05141250 0.04053333 0.02616667 -0.01436667 6.674639e-01 4.503716e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000029364 E001 1.9345371 0.0650622785 2.014778e-02 5.179430e-02 14 69398015 69398385 371 + 0.583 0.161 -2.655
ENSG00000029364 E002 2.5257233 0.0508539590 4.219121e-03 1.375613e-02 14 69398386 69398389 4 + 0.678 0.161 -3.068
ENSG00000029364 E003 7.0393160 0.0024242471 2.792553e-06 2.104965e-05 14 69398390 69398425 36 + 1.046 0.447 -2.489
ENSG00000029364 E004 9.6527000 0.0018203717 7.573696e-07 6.458762e-06 14 69398426 69398450 25 + 1.158 0.618 -2.088
ENSG00000029364 E005 9.8899456 0.0329425908 6.592481e-02 1.365782e-01 14 69398451 69398603 153 + 1.097 0.911 -0.687
ENSG00000029364 E006 6.1577512 0.1038460960 5.828804e-01 7.071179e-01 14 69398690 69398691 2 + 0.878 0.802 -0.294
ENSG00000029364 E007 19.3106523 0.0103264972 4.079410e-06 2.960022e-05 14 69398692 69398707 16 + 1.413 1.019 -1.399
ENSG00000029364 E008 43.0900205 0.0005156824 8.340904e-07 7.047046e-06 14 69398708 69398737 30 + 1.702 1.506 -0.669
ENSG00000029364 E009 217.7430812 0.0052878936 1.862826e-07 1.795232e-06 14 69398738 69399369 632 + 2.384 2.237 -0.491
ENSG00000029364 E010 73.8238703 0.0071909677 3.421205e-03 1.150056e-02 14 69399370 69399465 96 + 1.904 1.805 -0.335
ENSG00000029364 E011 95.6518651 0.0064198948 9.996352e-05 5.216878e-04 14 69424094 69424202 109 + 2.027 1.890 -0.460
ENSG00000029364 E012 8.9712209 0.0284875370 4.401504e-01 5.818396e-01 14 69428562 69429457 896 + 0.919 1.074 0.572
ENSG00000029364 E013 5.9451910 0.0071179362 1.217019e-01 2.223642e-01 14 69441832 69441972 141 + 0.880 0.741 -0.548
ENSG00000029364 E014 116.0339233 0.0091799489 1.375572e-03 5.226805e-03 14 69442069 69442266 198 + 2.102 1.986 -0.388
ENSG00000029364 E015 65.7133910 0.0252359585 2.560917e-01 3.930471e-01 14 69453241 69453309 69 + 1.834 1.778 -0.192
ENSG00000029364 E016 0.4355181 0.6755273456 4.860042e-01 6.238112e-01 14 69454701 69454811 111 + 0.230 0.001 -9.107
ENSG00000029364 E017 72.0663131 0.0219754095 1.474377e-01 2.582078e-01 14 69454812 69454897 86 + 1.881 1.805 -0.255
ENSG00000029364 E018 95.9582328 0.0125042915 9.398876e-02 1.813633e-01 14 69455732 69455866 135 + 1.998 1.941 -0.191
ENSG00000029364 E019 94.0417028 0.0076990341 9.622723e-02 1.847176e-01 14 69458363 69458464 102 + 1.981 1.951 -0.101
ENSG00000029364 E020 164.7160529 0.0033654250 5.087894e-08 5.476315e-07 14 69458465 69458729 265 + 2.263 2.118 -0.484
ENSG00000029364 E021 1279.2413977 0.0011940513 3.005846e-02 7.207113e-02 14 69458730 69461696 2967 + 3.059 3.160 0.337
ENSG00000029364 E022 493.3595741 0.0123738035 6.055618e-11 1.106286e-09 14 69461697 69462390 694 + 2.480 2.888 1.359