ENSG00000029363

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392348 ENSG00000029363 HEK293_OSMI2_2hA HEK293_TMG_2hB BCLAF1 protein_coding protein_coding 112.4842 23.6043 173.8867 2.203966 7.017938 2.880497 6.037955 0.000000 9.057018 0.00000000 0.3564055 9.824484 0.03367083 0.00000000 0.05240000 0.05240000 3.744158e-21 1.253043e-55 FALSE TRUE
ENST00000527536 ENSG00000029363 HEK293_OSMI2_2hA HEK293_TMG_2hB BCLAF1 protein_coding protein_coding 112.4842 23.6043 173.8867 2.203966 7.017938 2.880497 37.970106 12.045834 54.176666 0.91714551 2.8107533 2.168206 0.39787083 0.51296667 0.31123333 -0.20173333 1.934440e-08 1.253043e-55 FALSE TRUE
ENST00000527613 ENSG00000029363 HEK293_OSMI2_2hA HEK293_TMG_2hB BCLAF1 protein_coding nonsense_mediated_decay 112.4842 23.6043 173.8867 2.203966 7.017938 2.880497 10.001533 2.600548 16.242791 0.08722694 1.8599056 2.638263 0.09974583 0.11176667 0.09443333 -0.01733333 7.140144e-01 1.253043e-55 TRUE TRUE
ENST00000534762 ENSG00000029363 HEK293_OSMI2_2hA HEK293_TMG_2hB BCLAF1 protein_coding protein_coding 112.4842 23.6043 173.8867 2.203966 7.017938 2.880497 16.580361 4.551082 25.324011 0.93198501 2.7132854 2.473627 0.16365833 0.19023333 0.14500000 -0.04523333 4.160817e-01 1.253043e-55 FALSE TRUE
ENST00000628517 ENSG00000029363 HEK293_OSMI2_2hA HEK293_TMG_2hB BCLAF1 protein_coding protein_coding 112.4842 23.6043 173.8867 2.203966 7.017938 2.880497 16.591877 0.000000 30.911455 0.00000000 1.9641059 11.594392 0.08945833 0.00000000 0.17763333 0.17763333 1.253043e-55 1.253043e-55 FALSE TRUE
MSTRG.29013.14 ENSG00000029363 HEK293_OSMI2_2hA HEK293_TMG_2hB BCLAF1 protein_coding   112.4842 23.6043 173.8867 2.203966 7.017938 2.880497 9.949495 1.016516 14.993953 0.55773808 1.5104691 3.869514 0.07825417 0.03926667 0.08656667 0.04730000 5.724587e-01 1.253043e-55 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000029363 E001 0.2987644 0.0274045059 1.000000e+00   6 136256627 136256862 236 - 0.106 0.000 -8.055
ENSG00000029363 E002 79.7217683 0.0354985979 6.237918e-02 1.306528e-01 6 136256863 136258293 1431 - 1.739 1.987 0.835
ENSG00000029363 E003 61.8897697 0.0621091177 1.808807e-02 4.731811e-02 6 136258294 136258525 232 - 1.586 1.981 1.338
ENSG00000029363 E004 44.2602408 0.0948863914 9.202348e-02 1.782701e-01 6 136258526 136258585 60 - 1.450 1.828 1.286
ENSG00000029363 E005 30.9494517 0.0901686720 2.159039e-02 5.483109e-02 6 136258586 136258592 7 - 1.274 1.725 1.550
ENSG00000029363 E006 1162.6800626 0.0189696478 1.699310e-07 1.651512e-06 6 136258593 136259350 758 - 2.856 3.230 1.242
ENSG00000029363 E007 832.4867308 0.0007281136 3.844773e-17 1.737964e-15 6 136259351 136259690 340 - 2.763 2.959 0.652
ENSG00000029363 E008 261.8650109 0.0018994185 2.775093e-03 9.598923e-03 6 136259691 136259695 5 - 2.278 2.416 0.463
ENSG00000029363 E009 1482.1342659 0.0005804526 8.935128e-06 6.008992e-05 6 136259696 136260745 1050 - 3.035 3.139 0.346
ENSG00000029363 E010 350.7690891 0.0015483973 9.857962e-01 9.951422e-01 6 136260746 136260894 149 - 2.424 2.461 0.124
ENSG00000029363 E011 98.3378801 0.0040512643 2.832416e-02 6.865049e-02 6 136260895 136260901 7 - 1.852 2.005 0.514
ENSG00000029363 E012 122.9062408 0.0035585574 4.867351e-04 2.109453e-03 6 136260902 136260927 26 - 1.935 2.138 0.679
ENSG00000029363 E013 157.4802206 0.0006154803 1.215564e-06 9.914538e-06 6 136260928 136261003 76 - 2.040 2.248 0.695
ENSG00000029363 E014 110.7641389 0.0002574650 7.011487e-04 2.903209e-03 6 136261004 136261029 26 - 1.898 2.072 0.586
ENSG00000029363 E015 249.2010608 0.0001717627 5.796915e-03 1.807899e-02 6 136261030 136261109 80 - 2.260 2.374 0.381
ENSG00000029363 E016 199.2841692 0.0001783001 8.557482e-01 9.108059e-01 6 136261110 136261115 6 - 2.179 2.221 0.140
ENSG00000029363 E017 321.3423640 0.0001384505 9.710032e-01 9.858815e-01 6 136261265 136261300 36 - 2.386 2.421 0.117
ENSG00000029363 E018 670.0900088 0.0004622621 3.814656e-01 5.257540e-01 6 136261301 136261477 177 - 2.707 2.726 0.063
ENSG00000029363 E019 498.9559912 0.0006971300 3.689059e-02 8.526061e-02 6 136267029 136267175 147 - 2.585 2.571 -0.048
ENSG00000029363 E020 440.6974086 0.0002712166 1.866962e-02 4.860587e-02 6 136268162 136268273 112 - 2.532 2.513 -0.064
ENSG00000029363 E021 310.5165951 0.0005548542 3.888686e-01 5.329600e-01 6 136268274 136268339 66 - 2.376 2.387 0.038
ENSG00000029363 E022 13.9406737 0.0044849975 5.104473e-01 6.456489e-01 6 136268340 136268671 332 - 1.040 1.147 0.388
ENSG00000029363 E023 8.6444933 0.0019435379 9.512872e-02 1.830697e-01 6 136269089 136269140 52 - 0.913 0.684 -0.910
ENSG00000029363 E024 34.7860216 0.0101495246 5.275011e-01 6.605514e-01 6 136269141 136269230 90 - 1.444 1.421 -0.081
ENSG00000029363 E025 25.1143280 0.0123845999 5.281657e-02 1.141631e-01 6 136269231 136269261 31 - 1.332 1.148 -0.648
ENSG00000029363 E026 17.6590884 0.0341712689 2.309584e-01 3.636258e-01 6 136269262 136269263 2 - 1.183 1.043 -0.505
ENSG00000029363 E027 22.9549054 0.0136068121 4.977864e-01 6.343186e-01 6 136269264 136269303 40 - 1.275 1.234 -0.146
ENSG00000029363 E028 5.2661954 0.0045383700 7.324885e-01 8.239386e-01 6 136269304 136269436 133 - 0.712 0.684 -0.117
ENSG00000029363 E029 325.1198871 0.0042189319 2.208927e-01 3.514998e-01 6 136269437 136269475 39 - 2.399 2.387 -0.041
ENSG00000029363 E030 514.6508055 0.0112685030 3.937263e-01 5.376186e-01 6 136269476 136269612 137 - 2.597 2.594 -0.009
ENSG00000029363 E031 5.7784534 0.0031260097 3.039799e-01 4.459560e-01 6 136269613 136269959 347 - 0.756 0.609 -0.619
ENSG00000029363 E032 4.8978002 0.0755352242 6.675905e-01 7.747747e-01 6 136270323 136270383 61 - 0.649 0.753 0.435
ENSG00000029363 E033 2.7918437 0.0205787470 1.980289e-02 5.106667e-02 6 136271919 136271994 76 - 0.559 0.000 -12.584
ENSG00000029363 E034 392.0403055 0.0094498725 2.664336e-01 4.046160e-01 6 136271995 136272076 82 - 2.482 2.463 -0.062
ENSG00000029363 E035 232.3088632 0.0034227965 1.836922e-02 4.794172e-02 6 136272077 136272079 3 - 2.263 2.197 -0.221
ENSG00000029363 E036 446.8252549 0.0001838988 8.166325e-08 8.437883e-07 6 136273082 136273187 106 - 2.550 2.459 -0.305
ENSG00000029363 E037 4.1437249 0.0038126980 8.217047e-01 8.875366e-01 6 136273188 136273550 363 - 0.621 0.609 -0.055
ENSG00000029363 E038 27.3995473 0.0012576711 3.780712e-01 5.223678e-01 6 136273963 136274189 227 - 1.348 1.304 -0.154
ENSG00000029363 E039 241.1400129 0.0001925317 7.783078e-10 1.178265e-08 6 136275532 136275554 23 - 2.294 2.125 -0.563
ENSG00000029363 E040 411.9394847 0.0001468535 2.822260e-13 7.528424e-12 6 136275555 136275701 147 - 2.523 2.375 -0.494
ENSG00000029363 E041 360.5171256 0.0006842035 6.690035e-08 7.029435e-07 6 136275843 136275989 147 - 2.462 2.341 -0.402
ENSG00000029363 E042 357.3745425 0.0043036319 8.726307e-04 3.518512e-03 6 136275990 136276467 478 - 2.455 2.354 -0.339
ENSG00000029363 E043 37.4118736 0.0030024733 1.219100e-02 3.398894e-02 6 136276468 136276508 41 - 1.499 1.320 -0.619
ENSG00000029363 E044 840.5996251 0.0066396670 1.161407e-10 2.027964e-09 6 136277865 136278746 882 - 2.844 2.606 -0.791
ENSG00000029363 E045 235.0307660 0.0136260683 9.212930e-07 7.705420e-06 6 136278747 136278770 24 - 2.298 2.000 -0.995
ENSG00000029363 E046 179.9205754 0.0009914577 5.786184e-13 1.474940e-11 6 136278771 136278776 6 - 2.179 1.903 -0.927
ENSG00000029363 E047 0.8275069 0.6559168109 6.641291e-01 7.719988e-01 6 136279483 136279762 280 - 0.193 0.255 0.510
ENSG00000029363 E048 318.1948652 0.0259922450 7.233074e-05 3.914427e-04 6 136279763 136279876 114 - 2.428 2.138 -0.970
ENSG00000029363 E049 0.5933762 0.0214242930 5.593879e-01 6.874987e-01 6 136282316 136282384 69 - 0.191 0.000 -10.358
ENSG00000029363 E050 335.3788670 0.0001933758 3.764727e-33 7.986744e-31 6 136282584 136282687 104 - 2.455 2.118 -1.126
ENSG00000029363 E051 260.3454963 0.0007612718 1.789160e-21 1.351479e-19 6 136289713 136289851 139 - 2.344 2.028 -1.057