ENSG00000028203

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000436874 ENSG00000028203 HEK293_OSMI2_2hA HEK293_TMG_2hB VEZT protein_coding protein_coding 20.08176 4.3643 33.84213 0.3785278 0.6999972 2.952123 3.9389555 1.5278817 5.8993226 0.17254582 0.36079977 1.9420482 0.23977500 0.35200000 0.174133333 -0.17786667 3.629963e-04 1.400861e-07 FALSE TRUE
ENST00000547611 ENSG00000028203 HEK293_OSMI2_2hA HEK293_TMG_2hB VEZT protein_coding nonsense_mediated_decay 20.08176 4.3643 33.84213 0.3785278 0.6999972 2.952123 1.5886609 0.0826219 3.4498598 0.08262190 0.81095057 5.2232164 0.04681250 0.02186667 0.101066667 0.07920000 1.548085e-01 1.400861e-07 TRUE TRUE
ENST00000549192 ENSG00000028203 HEK293_OSMI2_2hA HEK293_TMG_2hB VEZT protein_coding retained_intron 20.08176 4.3643 33.84213 0.3785278 0.6999972 2.952123 1.7422298 0.2085516 3.3443795 0.01865179 0.09007719 3.9400001 0.07081250 0.04783333 0.098966667 0.05113333 2.505037e-02 1.400861e-07 FALSE TRUE
ENST00000549589 ENSG00000028203 HEK293_OSMI2_2hA HEK293_TMG_2hB VEZT protein_coding processed_transcript 20.08176 4.3643 33.84213 0.3785278 0.6999972 2.952123 0.1515460 0.5372258 0.0768477 0.30173612 0.03843885 -2.6555768 0.02631667 0.11340000 0.002233333 -0.11116667 1.506448e-04 1.400861e-07   FALSE
ENST00000552660 ENSG00000028203 HEK293_OSMI2_2hA HEK293_TMG_2hB VEZT protein_coding nonsense_mediated_decay 20.08176 4.3643 33.84213 0.3785278 0.6999972 2.952123 3.1296346 0.5072395 5.0516555 0.33006433 0.44098286 3.2907050 0.16174167 0.13040000 0.149000000 0.01860000 7.792892e-01 1.400861e-07 FALSE TRUE
MSTRG.7816.4 ENSG00000028203 HEK293_OSMI2_2hA HEK293_TMG_2hB VEZT protein_coding   20.08176 4.3643 33.84213 0.3785278 0.6999972 2.952123 0.9549645 0.0000000 2.3214569 0.00000000 0.25676357 7.8650879 0.03212083 0.00000000 0.068600000 0.06860000 1.400861e-07 1.400861e-07 FALSE TRUE
MSTRG.7816.9 ENSG00000028203 HEK293_OSMI2_2hA HEK293_TMG_2hB VEZT protein_coding   20.08176 4.3643 33.84213 0.3785278 0.6999972 2.952123 0.6228228 0.4039149 0.3557820 0.40391487 0.35578201 -0.1783499 0.05569583 0.09523333 0.010733333 -0.08450000 7.792892e-01 1.400861e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000028203 E001 0.0000000       12 95217746 95217752 7 +      
ENSG00000028203 E002 0.1817044 0.0412601567 6.480418e-02   12 95217753 95217757 5 + 0.000 0.253 13.139
ENSG00000028203 E003 0.3332198 0.0306513240 2.056804e-01   12 95217758 95217760 3 + 0.055 0.253 2.556
ENSG00000028203 E004 0.6319842 0.0234323966 5.794178e-01 7.043290e-01 12 95217761 95217761 1 + 0.147 0.253 0.971
ENSG00000028203 E005 0.7771569 0.0153003659 7.507281e-01 8.373310e-01 12 95217762 95217762 1 + 0.187 0.253 0.556
ENSG00000028203 E006 0.9244060 0.0136968632 9.153605e-01 9.504440e-01 12 95217763 95217763 1 + 0.223 0.253 0.234
ENSG00000028203 E007 1.3704194 0.0141522701 7.532358e-01 8.392535e-01 12 95217764 95217770 7 + 0.317 0.253 -0.444
ENSG00000028203 E008 1.3704194 0.0141522701 7.532358e-01 8.392535e-01 12 95217771 95217771 1 + 0.317 0.253 -0.444
ENSG00000028203 E009 1.3704194 0.0141522701 7.532358e-01 8.392535e-01 12 95217772 95217779 8 + 0.317 0.253 -0.444
ENSG00000028203 E010 2.0983592 0.0066717922 3.776454e-01 5.219584e-01 12 95217780 95217798 19 + 0.438 0.253 -1.145
ENSG00000028203 E011 2.2498747 0.0064532404 3.282988e-01 4.717858e-01 12 95217799 95217806 8 + 0.459 0.253 -1.252
ENSG00000028203 E012 2.2498747 0.0064532404 3.282988e-01 4.717858e-01 12 95217807 95217807 1 + 0.459 0.253 -1.252
ENSG00000028203 E013 2.3950474 0.0062401166 2.852389e-01 4.255436e-01 12 95217808 95217809 2 + 0.479 0.253 -1.351
ENSG00000028203 E014 2.3950474 0.0062401166 2.852389e-01 4.255436e-01 12 95217810 95217810 1 + 0.479 0.253 -1.351
ENSG00000028203 E015 2.6948560 0.0054860734 6.405359e-01 7.537586e-01 12 95217811 95217811 1 + 0.498 0.411 -0.445
ENSG00000028203 E016 5.2099701 0.0041843782 2.625620e-01 4.003540e-01 12 95217812 95217817 6 + 0.724 0.527 -0.860
ENSG00000028203 E017 15.8141024 0.0012875687 5.109228e-01 6.460649e-01 12 95217818 95217823 6 + 1.117 1.052 -0.235
ENSG00000028203 E018 18.6874259 0.0033514621 9.968199e-01 1.000000e+00 12 95217824 95217825 2 + 1.171 1.182 0.041
ENSG00000028203 E019 36.6105232 0.0006329327 6.345323e-01 7.489594e-01 12 95217826 95217841 16 + 1.457 1.432 -0.086
ENSG00000028203 E020 63.9065590 0.0004377994 3.414759e-01 4.853707e-01 12 95217842 95217886 45 + 1.677 1.744 0.226
ENSG00000028203 E021 0.0000000       12 95218065 95218115 51 +      
ENSG00000028203 E022 0.2214452 0.0404153921 6.466118e-02   12 95218116 95218128 13 + 0.000 0.253 15.001
ENSG00000028203 E023 0.2214452 0.0404153921 6.466118e-02   12 95218129 95218228 100 + 0.000 0.253 15.001
ENSG00000028203 E024 0.0000000       12 95218229 95218229 1 +      
ENSG00000028203 E025 0.0000000       12 95218230 95218253 24 +      
ENSG00000028203 E026 0.0000000       12 95218254 95218254 1 +      
ENSG00000028203 E027 0.2214452 0.0404153921 6.466118e-02   12 95218255 95218260 6 + 0.000 0.253 15.001
ENSG00000028203 E028 0.4428904 0.4858324367 3.399779e-02 7.975703e-02 12 95218261 95218277 17 + 0.000 0.426 15.167
ENSG00000028203 E029 0.3686942 0.0309545100 2.056757e-01 3.332676e-01 12 95218278 95218309 32 + 0.055 0.253 2.559
ENSG00000028203 E030 0.3686942 0.0309545100 2.056757e-01 3.332676e-01 12 95218310 95218345 36 + 0.055 0.253 2.559
ENSG00000028203 E031 0.0000000       12 95218346 95218613 268 +      
ENSG00000028203 E032 4.1611346 0.0039975168 1.842808e-05 1.152802e-04 12 95224180 95224236 57 + 0.417 1.052 2.672
ENSG00000028203 E033 0.0000000       12 95231412 95231545 134 +      
ENSG00000028203 E034 9.4178590 0.0334799443 4.676150e-06 3.351046e-05 12 95242164 95242264 101 + 0.712 1.337 2.317
ENSG00000028203 E035 2.4335485 0.0064516380 2.578244e-06 1.958934e-05 12 95242265 95242314 50 + 0.187 0.949 3.878
ENSG00000028203 E036 2.2383471 0.1562719730 9.698744e-01 9.851524e-01 12 95243941 95244009 69 + 0.438 0.410 -0.150
ENSG00000028203 E037 58.7032395 0.0005654788 2.900821e-02 7.002267e-02 12 95251940 95251944 5 + 1.675 1.543 -0.449
ENSG00000028203 E038 65.8795235 0.0012070649 1.418792e-02 3.865225e-02 12 95251945 95251966 22 + 1.726 1.581 -0.493
ENSG00000028203 E039 105.6066693 0.0002663767 4.427143e-05 2.526765e-04 12 95251967 95252071 105 + 1.933 1.738 -0.659
ENSG00000028203 E040 0.6017953 0.1439936529 7.021946e-01 8.010542e-01 12 95252072 95252440 369 + 0.187 0.000 -14.255
ENSG00000028203 E041 40.3376015 0.0005343014 3.665959e-02 8.482607e-02 12 95256550 95256622 73 + 1.518 1.364 -0.532
ENSG00000028203 E042 58.7580944 0.0004069095 1.987207e-02 5.121906e-02 12 95257150 95257153 4 + 1.675 1.533 -0.482
ENSG00000028203 E043 97.1047369 0.0017983817 3.830029e-02 8.791163e-02 12 95257154 95257239 86 + 1.885 1.785 -0.335
ENSG00000028203 E044 1.9367272 0.0110587689 4.345682e-01 5.769039e-01 12 95258245 95258282 38 + 0.417 0.252 -1.031
ENSG00000028203 E045 0.8921407 0.0130873786 3.702418e-01 5.146732e-01 12 95258283 95258287 5 + 0.257 0.000 -15.487
ENSG00000028203 E046 0.2955422 0.0290969634 2.071409e-01   12 95262304 95262412 109 + 0.055 0.252 2.553
ENSG00000028203 E047 127.5609424 0.0036964329 6.226236e-02 1.304413e-01 12 95262906 95263081 176 + 2.000 1.915 -0.286
ENSG00000028203 E048 0.1515154 0.0428973895 1.000000e+00   12 95263746 95263797 52 + 0.055 0.000 -12.695
ENSG00000028203 E049 197.6029324 0.0001986162 3.580737e-02 8.320883e-02 12 95266357 95266632 276 + 2.185 2.126 -0.198
ENSG00000028203 E050 0.0000000       12 95266633 95266633 1 +      
ENSG00000028203 E051 0.3030308 0.3694521216 1.000000e+00   12 95269824 95270038 215 + 0.104 0.000 -12.979
ENSG00000028203 E052 28.8533846 0.0007049322 2.419439e-01 3.764885e-01 12 95270039 95270050 12 + 1.374 1.282 -0.322
ENSG00000028203 E053 123.8854388 0.0002285573 5.937384e-01 7.160698e-01 12 95270051 95270188 138 + 1.976 1.966 -0.034
ENSG00000028203 E054 61.8861744 0.0004088162 1.230188e-01 2.242622e-01 12 95274742 95274745 4 + 1.691 1.607 -0.284
ENSG00000028203 E055 129.8106397 0.0002524203 2.013200e-01 3.278332e-01 12 95274746 95274889 144 + 2.000 1.959 -0.139
ENSG00000028203 E056 0.4482035 0.0265990821 1.000000e+00 1.000000e+00 12 95274890 95274891 2 + 0.147 0.000 -14.385
ENSG00000028203 E057 77.0103971 0.0023743894 2.328136e-01 3.657717e-01 12 95282313 95282359 47 + 1.779 1.719 -0.203
ENSG00000028203 E058 189.3832552 0.0003683673 5.591058e-03 1.753048e-02 12 95282360 95282644 285 + 2.170 2.083 -0.293
ENSG00000028203 E059 149.7532595 0.0002309211 6.568530e-02 1.361892e-01 12 95287664 95287857 194 + 2.066 2.005 -0.202
ENSG00000028203 E060 0.1482932 0.0411437115 6.545360e-02   12 95287858 95287864 7 + 0.000 0.252 14.988
ENSG00000028203 E061 0.1482932 0.0411437115 6.545360e-02   12 95293684 95294271 588 + 0.000 0.252 14.988
ENSG00000028203 E062 125.1933083 0.0003393562 3.644504e-01 5.088112e-01 12 95294272 95294372 101 + 1.985 1.959 -0.088
ENSG00000028203 E063 66.1464223 0.0009571309 4.733375e-01 6.122949e-01 12 95296051 95296068 18 + 1.714 1.684 -0.101
ENSG00000028203 E064 149.6088371 0.0003151484 8.718366e-02 1.708740e-01 12 95296069 95296258 190 + 2.044 2.120 0.255
ENSG00000028203 E065 5.2518218 0.0031328717 3.355729e-02 7.888482e-02 12 95296259 95296956 698 + 0.625 0.949 1.292
ENSG00000028203 E066 17.2885857 0.0011606026 2.797240e-01 4.194898e-01 12 95298862 95298943 82 + 1.163 1.051 -0.402
ENSG00000028203 E067 8.1711192 0.0037041276 2.934739e-01 4.345373e-01 12 95299094 95300164 1071 + 0.831 0.985 0.587
ENSG00000028203 E068 452.5041417 0.0008270638 1.714022e-24 1.787102e-22 12 95300165 95302799 2635 + 2.485 2.715 0.764