ENSG00000026652

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320285 ENSG00000026652 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT4 protein_coding protein_coding 14.93221 17.49387 11.5958 0.3059572 0.6705128 -0.5928278 2.0101295 1.7471692 2.3097590 0.3674607 0.5106142 0.4007219 0.14050000 0.09966667 0.2045000 0.1048333 2.406235e-01 4.526998e-06 FALSE TRUE
ENST00000366911 ENSG00000026652 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT4 protein_coding protein_coding 14.93221 17.49387 11.5958 0.3059572 0.6705128 -0.5928278 0.7777997 0.7327906 0.8061418 0.3924784 0.4192283 0.1358643 0.05419167 0.04210000 0.0670000 0.0249000 9.490993e-01 4.526998e-06 FALSE TRUE
MSTRG.29288.3 ENSG00000026652 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT4 protein_coding   14.93221 17.49387 11.5958 0.3059572 0.6705128 -0.5928278 10.9858569 14.1796602 7.5604666 0.2989376 0.6407344 -0.9063859 0.72691250 0.81046667 0.6499667 -0.1605000 4.526998e-06 4.526998e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000026652 E001 0.1482932 0.0414774617 6.997133e-01   6 161129967 161129978 12 - 0.000 0.096 8.127
ENSG00000026652 E002 421.6662400 0.0046023464 3.039700e-19 1.778999e-17 6 161129979 161136236 6258 - 2.784 2.468 -1.052
ENSG00000026652 E003 268.8046509 0.0003729467 1.058928e-11 2.196067e-10 6 161136237 161136634 398 - 2.334 2.434 0.333
ENSG00000026652 E004 184.4937218 0.0002432956 1.121106e-04 5.775486e-04 6 161139422 161139620 199 - 2.208 2.256 0.162
ENSG00000026652 E005 1.4716710 0.0155212935 2.383165e-02 5.946676e-02 6 161143956 161144266 311 - 0.600 0.176 -2.577
ENSG00000026652 E006 96.6457844 0.0013072000 8.814927e-04 3.549409e-03 6 161146524 161146599 76 - 1.906 1.986 0.269
ENSG00000026652 E007 60.1673607 0.0003920919 2.176447e-03 7.769111e-03 6 161149187 161149204 18 - 1.695 1.787 0.313
ENSG00000026652 E008 72.8319979 0.0003470563 7.186939e-04 2.965793e-03 6 161149205 161149255 51 - 1.776 1.869 0.313
ENSG00000026652 E009 57.5404001 0.0004357738 1.183753e-04 6.064151e-04 6 161149256 161149289 34 - 1.643 1.780 0.463
ENSG00000026652 E010 113.2298739 0.0003321161 2.676659e-02 6.550471e-02 6 161153346 161153499 154 - 2.015 2.037 0.072
ENSG00000026652 E011 122.3366548 0.0003400781 5.570745e-01 6.855709e-01 6 161154149 161154310 162 - 2.086 2.050 -0.119
ENSG00000026652 E012 29.1729670 0.0177580938 1.364894e-02 3.742583e-02 6 161160105 161165576 5472 - 1.621 1.347 -0.943
ENSG00000026652 E013 5.2130324 0.0199339696 4.635634e-01 6.033423e-01 6 161165577 161165713 137 - 0.868 0.718 -0.597
ENSG00000026652 E014 4.3155801 0.0038640586 3.425845e-01 4.865808e-01 6 161165838 161166247 410 - 0.644 0.739 0.395
ENSG00000026652 E015 112.7715712 0.0002863560 4.788620e-02 1.054222e-01 6 161166248 161166417 170 - 2.020 2.033 0.044
ENSG00000026652 E016 141.7710000 0.0036798753 4.255580e-01 5.684999e-01 6 161232036 161232302 267 - 2.141 2.118 -0.079
ENSG00000026652 E017 56.3064311 0.0065473511 2.921818e-01 4.331286e-01 6 161273938 161274069 132 - 1.720 1.730 0.033