ENSG00000024526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370966 ENSG00000024526 HEK293_OSMI2_2hA HEK293_TMG_2hB DEPDC1 protein_coding protein_coding 37.34262 6.03861 61.06715 0.5814539 2.328087 3.335957 5.820045 4.3119645 7.218962 0.5608838 0.4398692 0.7421014 0.32972083 0.71143333 0.11820000 -0.59323333 1.047984e-21 1.047984e-21 FALSE TRUE
ENST00000456315 ENSG00000024526 HEK293_OSMI2_2hA HEK293_TMG_2hB DEPDC1 protein_coding protein_coding 37.34262 6.03861 61.06715 0.5814539 2.328087 3.335957 8.385755 1.1556339 14.675663 0.1049481 0.7771112 3.6552218 0.21546667 0.19436667 0.24053333 0.04616667 4.094507e-01 1.047984e-21 FALSE TRUE
ENST00000525124 ENSG00000024526 HEK293_OSMI2_2hA HEK293_TMG_2hB DEPDC1 protein_coding protein_coding 37.34262 6.03861 61.06715 0.5814539 2.328087 3.335957 1.682922 0.0000000 4.025674 0.0000000 0.1858498 8.6566659 0.02581667 0.00000000 0.06606667 0.06606667 3.725576e-11 1.047984e-21   FALSE
MSTRG.1387.5 ENSG00000024526 HEK293_OSMI2_2hA HEK293_TMG_2hB DEPDC1 protein_coding   37.34262 6.03861 61.06715 0.5814539 2.328087 3.335957 11.696326 0.2315752 18.307296 0.2315752 0.7068763 6.2445905 0.24079583 0.03463333 0.30000000 0.26536667 3.935216e-02 1.047984e-21 FALSE TRUE
MSTRG.1387.9 ENSG00000024526 HEK293_OSMI2_2hA HEK293_TMG_2hB DEPDC1 protein_coding   37.34262 6.03861 61.06715 0.5814539 2.328087 3.335957 6.314387 0.0000000 11.823257 0.0000000 2.0161119 10.2086315 0.09441250 0.00000000 0.19283333 0.19283333 3.059940e-13 1.047984e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000024526 E001 370.884461 0.0380673975 1.086840e-05 7.161189e-05 1 68474152 68475080 929 - 2.309 2.772 1.543
ENSG00000024526 E002 80.709061 0.0003299373 1.183001e-26 1.481269e-24 1 68475081 68475573 493 - 1.633 2.154 1.754
ENSG00000024526 E003 61.575457 0.0003864756 6.163429e-22 4.871268e-20 1 68475574 68475654 81 - 1.514 2.046 1.798
ENSG00000024526 E004 443.033589 0.0005430602 2.560309e-26 3.131329e-24 1 68475655 68476207 553 - 2.435 2.716 0.937
ENSG00000024526 E005 169.579823 0.0002404945 6.609879e-12 1.417503e-10 1 68476208 68476540 333 - 2.019 2.297 0.929
ENSG00000024526 E006 332.056790 0.0002262146 3.132616e-03 1.065543e-02 1 68476541 68476896 356 - 2.342 2.462 0.400
ENSG00000024526 E007 204.775977 0.0002155259 1.658827e-01 2.828417e-01 1 68476897 68477063 167 - 2.138 2.227 0.297
ENSG00000024526 E008 77.403730 0.0005472386 1.165691e-01 2.150517e-01 1 68477064 68477069 6 - 1.713 1.840 0.429
ENSG00000024526 E009 218.129791 0.0037209759 2.585261e-01 3.958024e-01 1 68477787 68477972 186 - 2.179 2.170 -0.032
ENSG00000024526 E010 264.987755 0.0003011045 5.123554e-05 2.879474e-04 1 68479144 68479320 177 - 2.274 2.178 -0.321
ENSG00000024526 E011 264.826055 0.0006184982 1.602393e-07 1.565032e-06 1 68481440 68481612 173 - 2.280 2.132 -0.496
ENSG00000024526 E012 16.469022 0.1278527378 1.529779e-01 2.657184e-01 1 68481613 68482045 433 - 1.120 0.862 -0.955
ENSG00000024526 E013 172.344467 0.0002140357 1.421527e-09 2.047784e-08 1 68482046 68482640 595 - 2.103 1.872 -0.775
ENSG00000024526 E014 82.553984 0.0330611385 9.965524e-03 2.867856e-02 1 68482641 68482897 257 - 1.791 1.532 -0.877
ENSG00000024526 E015 5.639475 0.0103502246 3.090247e-02 7.372625e-02 1 68483097 68483231 135 - 0.730 0.278 -2.287
ENSG00000024526 E016 6.627343 0.0083987876 1.072536e-03 4.209681e-03 1 68483232 68483272 41 - 0.800 0.000 -12.315
ENSG00000024526 E017 6.848789 0.0083277922 1.133978e-02 3.197618e-02 1 68483273 68483305 33 - 0.800 0.278 -2.568
ENSG00000024526 E018 234.762562 0.0003162413 5.414358e-06 3.823513e-05 1 68483950 68484090 141 - 2.225 2.099 -0.422
ENSG00000024526 E019 120.076273 0.0002507937 9.248612e-05 4.867140e-04 1 68486937 68486940 4 - 1.940 1.779 -0.543
ENSG00000024526 E020 154.148484 0.0002661375 1.245812e-04 6.347569e-04 1 68486941 68486984 44 - 2.044 1.912 -0.444
ENSG00000024526 E021 243.927694 0.0001759991 1.183378e-06 9.677429e-06 1 68488374 68488504 131 - 2.243 2.111 -0.441
ENSG00000024526 E022 253.620313 0.0002552714 1.086624e-09 1.600884e-08 1 68488916 68489034 119 - 2.266 2.086 -0.600
ENSG00000024526 E023 158.480567 0.0002930149 1.131682e-06 9.289562e-06 1 68489452 68489485 34 - 2.064 1.882 -0.609
ENSG00000024526 E024 222.652437 0.0002035814 7.067857e-10 1.079565e-08 1 68489486 68489569 84 - 2.211 2.013 -0.663
ENSG00000024526 E025 165.289753 0.0003483579 3.268735e-07 3.000979e-06 1 68489570 68489608 39 - 2.082 1.892 -0.637
ENSG00000024526 E026 318.369540 0.0061411912 9.426813e-10 1.404326e-08 1 68494430 68494695 266 - 2.372 2.095 -0.924
ENSG00000024526 E027 2.364858 0.0060706695 7.477486e-02 1.511643e-01 1 68496796 68496951 156 - 0.461 0.000 -10.824
ENSG00000024526 E028 175.451703 0.0050587634 2.813772e-09 3.840772e-08 1 68496952 68497223 272 - 2.117 1.805 -1.048