ENSG00000024048

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372899 ENSG00000024048 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR2 protein_coding protein_coding 6.493115 2.462194 9.368106 0.09186129 0.2715912 1.923504 1.0039933 0.09394659 1.22399747 0.06539822 0.22673265 3.569425 0.1308917 0.03926667 0.131933333 0.09266667 2.150552e-01 5.192175e-09 FALSE TRUE
ENST00000372901 ENSG00000024048 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR2 protein_coding protein_coding 6.493115 2.462194 9.368106 0.09186129 0.2715912 1.923504 4.8632275 1.07595450 8.04021834 0.08934194 0.44201756 2.890064 0.6645417 0.44013333 0.857100000 0.41696667 2.056194e-07 5.192175e-09 FALSE TRUE
MSTRG.28294.4 ENSG00000024048 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR2 protein_coding   6.493115 2.462194 9.368106 0.09186129 0.2715912 1.923504 0.5645126 1.26068726 0.04661735 0.22002925 0.04661735 -4.488221 0.1921958 0.50766667 0.004766667 -0.50290000 5.192175e-09 5.192175e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000024048 E001 12.829607 0.0113709867 2.693817e-01 4.078965e-01 6 42564029 42564061 33 + 1.059 0.961 -0.360
ENSG00000024048 E002 46.304394 0.0005559028 1.491835e-05 9.527497e-05 6 42564062 42564397 336 + 1.612 1.336 -0.949
ENSG00000024048 E003 56.823382 0.0144206749 3.147077e-03 1.069847e-02 6 42573734 42573993 260 + 1.690 1.477 -0.727
ENSG00000024048 E004 37.241949 0.0075250360 3.079692e-03 1.049992e-02 6 42592151 42592229 79 + 1.512 1.291 -0.767
ENSG00000024048 E005 39.118157 0.0007948814 1.070714e-03 4.203576e-03 6 42594191 42594304 114 + 1.531 1.322 -0.723
ENSG00000024048 E006 31.720259 0.0006103950 1.656982e-06 1.311673e-05 6 42603588 42603718 131 + 1.468 1.055 -1.455
ENSG00000024048 E007 37.648589 0.0005824969 2.579249e-06 1.959540e-05 6 42605721 42605859 139 + 1.534 1.177 -1.243
ENSG00000024048 E008 29.210000 0.0006935912 1.544943e-05 9.831537e-05 6 42606589 42606651 63 + 1.430 1.055 -1.325
ENSG00000024048 E009 35.056140 0.0007053583 1.688387e-04 8.301577e-04 6 42612171 42612291 121 + 1.493 1.218 -0.954
ENSG00000024048 E010 31.815976 0.0012858208 1.308508e-02 3.610651e-02 6 42615071 42615178 108 + 1.437 1.273 -0.570
ENSG00000024048 E011 29.558188 0.0006849953 2.330379e-02 5.838259e-02 6 42616002 42616090 89 + 1.404 1.255 -0.518
ENSG00000024048 E012 4.584441 0.0041521743 2.297474e-01 3.621527e-01 6 42617240 42617338 99 + 0.687 0.508 -0.802
ENSG00000024048 E013 28.396769 0.0007920958 4.404486e-02 9.846669e-02 6 42617409 42617507 99 + 1.384 1.256 -0.448
ENSG00000024048 E014 0.147249 0.0426670046 1.000000e+00   6 42619468 42620351 884 + 0.058 0.001 -6.423
ENSG00000024048 E015 40.393794 0.0210766640 2.082594e-01 3.363952e-01 6 42632552 42632715 164 + 1.523 1.448 -0.258
ENSG00000024048 E016 35.809357 0.0006138265 2.214558e-02 5.597915e-02 6 42632805 42632904 100 + 1.482 1.351 -0.454
ENSG00000024048 E017 46.841245 0.0004773683 2.956199e-02 7.109851e-02 6 42635418 42635546 129 + 1.594 1.496 -0.336
ENSG00000024048 E018 49.544728 0.0022692823 2.016883e-01 3.282863e-01 6 42637011 42637194 184 + 1.608 1.571 -0.126
ENSG00000024048 E019 34.037929 0.0010144129 6.683694e-02 1.381175e-01 6 42640209 42640270 62 + 1.461 1.365 -0.333
ENSG00000024048 E020 46.059840 0.0021720029 1.423151e-02 3.875346e-02 6 42641582 42641692 111 + 1.592 1.464 -0.440
ENSG00000024048 E021 34.094480 0.0006326503 1.029039e-01 1.948940e-01 6 42642416 42642481 66 + 1.457 1.379 -0.271
ENSG00000024048 E022 53.752387 0.0011648618 3.357104e-02 7.891421e-02 6 42644214 42644336 123 + 1.650 1.562 -0.300
ENSG00000024048 E023 37.221036 0.0006692398 3.670210e-04 1.646640e-03 6 42644473 42644536 64 + 1.516 1.273 -0.842
ENSG00000024048 E024 48.089106 0.0016280738 5.071007e-07 4.481235e-06 6 42645466 42645590 125 + 1.636 1.290 -1.193
ENSG00000024048 E025 31.282571 0.0006010865 3.741343e-03 1.241415e-02 6 42648118 42648170 53 + 1.439 1.237 -0.705
ENSG00000024048 E026 38.461178 0.0005640706 1.231733e-02 3.429572e-02 6 42650284 42650386 103 + 1.520 1.379 -0.486
ENSG00000024048 E027 30.574126 0.0006495111 2.515978e-03 8.811823e-03 6 42652023 42652071 49 + 1.435 1.218 -0.756
ENSG00000024048 E028 25.470518 0.0007349791 1.573792e-02 4.214375e-02 6 42652491 42652539 49 + 1.355 1.177 -0.624
ENSG00000024048 E029 39.367889 0.0005239026 7.832268e-02 1.567852e-01 6 42652540 42652645 106 + 1.520 1.441 -0.270
ENSG00000024048 E030 42.715107 0.0005299331 7.312773e-03 2.203217e-02 6 42655621 42655723 103 + 1.563 1.417 -0.499
ENSG00000024048 E031 44.914747 0.0005112716 2.047308e-03 7.372153e-03 6 42658024 42658133 110 + 1.589 1.417 -0.590
ENSG00000024048 E032 42.978970 0.0005340549 1.695961e-01 2.876692e-01 6 42658240 42658320 81 + 1.551 1.506 -0.153
ENSG00000024048 E033 63.976058 0.0004328095 9.285072e-01 9.590222e-01 6 42658646 42658824 179 + 1.696 1.752 0.187
ENSG00000024048 E034 58.564591 0.0011743666 9.615893e-01 9.797943e-01 6 42659656 42659855 200 + 1.657 1.710 0.180
ENSG00000024048 E035 39.251502 0.0005671124 9.138023e-01 9.494285e-01 6 42662184 42662277 94 + 1.493 1.535 0.145
ENSG00000024048 E036 51.214082 0.0004607608 9.790491e-01 9.909429e-01 6 42663258 42663419 162 + 1.605 1.657 0.176
ENSG00000024048 E037 37.123727 0.0012339928 4.298719e-01 5.725229e-01 6 42665409 42665512 104 + 1.482 1.474 -0.028
ENSG00000024048 E038 34.822544 0.0126063070 9.680119e-01 9.840045e-01 6 42666167 42666245 79 + 1.442 1.496 0.186
ENSG00000024048 E039 54.492320 0.0036547745 6.036163e-01 7.243740e-01 6 42670092 42670240 149 + 1.639 1.656 0.058
ENSG00000024048 E040 35.513533 0.0027578200 9.525677e-01 9.743067e-01 6 42670660 42670715 56 + 1.451 1.506 0.189
ENSG00000024048 E041 45.484795 0.0029489341 4.110976e-01 5.546897e-01 6 42673791 42673887 97 + 1.543 1.649 0.361
ENSG00000024048 E042 37.390610 0.0010663006 4.323122e-01 5.747708e-01 6 42674126 42674193 68 + 1.482 1.475 -0.027
ENSG00000024048 E043 50.671597 0.0004334003 3.903488e-01 5.343315e-01 6 42676056 42676191 136 + 1.589 1.691 0.345
ENSG00000024048 E044 45.925505 0.0010264168 1.211236e-02 3.380500e-02 6 42676783 42676873 91 + 1.525 1.728 0.690
ENSG00000024048 E045 56.236991 0.0074255476 9.622825e-02 1.847176e-01 6 42678539 42678669 131 + 1.621 1.783 0.548
ENSG00000024048 E046 63.183881 0.0004265336 9.500664e-05 4.985658e-04 6 42679724 42679832 109 + 1.643 1.891 0.839
ENSG00000024048 E047 49.066317 0.0006425653 3.391341e-06 2.509391e-05 6 42683055 42683111 57 + 1.512 1.825 1.063
ENSG00000024048 E048 52.986582 0.0011388922 2.757882e-06 2.081481e-05 6 42684794 42684871 78 + 1.547 1.857 1.053
ENSG00000024048 E049 80.374538 0.0018546808 4.276083e-05 2.448589e-04 6 42688216 42688386 171 + 1.745 1.994 0.839
ENSG00000024048 E050 64.256729 0.0004314666 2.068541e-07 1.977489e-06 6 42689569 42689670 102 + 1.636 1.942 1.033
ENSG00000024048 E051 278.186816 0.0191762950 5.418839e-08 5.796627e-07 6 42691032 42693505 2474 + 2.232 2.631 1.330