ENSG00000023892

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316637 ENSG00000023892 HEK293_OSMI2_2hA HEK293_TMG_2hB DEF6 protein_coding protein_coding 2.934843 4.946036 1.908707 0.2450486 0.03775925 -1.369053 1.0257679 2.395057 0.51268622 0.1439614 0.05325374 -2.2020543 0.3163583 0.48703333 0.26770000 -0.2193333 0.01417621 0.01417621 FALSE TRUE
ENST00000468102 ENSG00000023892 HEK293_OSMI2_2hA HEK293_TMG_2hB DEF6 protein_coding processed_transcript 2.934843 4.946036 1.908707 0.2450486 0.03775925 -1.369053 0.1652443 0.124619 0.09507735 0.1246190 0.05158128 -0.3574302 0.0584500 0.02306667 0.04906667 0.0260000 0.64959643 0.01417621 FALSE FALSE
MSTRG.28175.4 ENSG00000023892 HEK293_OSMI2_2hA HEK293_TMG_2hB DEF6 protein_coding   2.934843 4.946036 1.908707 0.2450486 0.03775925 -1.369053 1.6551976 2.233524 1.30094295 0.3420330 0.05962068 -0.7751618 0.6011458 0.45033333 0.68320000 0.2328667 0.07340168 0.01417621 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000023892 E001 10.204960 0.0017957047 0.9694674212 0.984912753 6 35297818 35297952 135 + 0.953 0.960 0.024
ENSG00000023892 E002 13.335135 0.0013960853 0.4167515568 0.560136303 6 35309670 35309737 68 + 0.982 1.075 0.340
ENSG00000023892 E003 13.913671 0.0015167634 0.1157086493 0.213826686 6 35309738 35309810 73 + 0.922 1.105 0.673
ENSG00000023892 E004 14.333808 0.0016683960 0.2963268549 0.437533971 6 35310459 35310569 111 + 0.982 1.099 0.430
ENSG00000023892 E005 10.000245 0.0201311058 0.0986026995 0.188361372 6 35310570 35310644 75 + 0.724 0.972 0.964
ENSG00000023892 E006 18.396984 0.0260230961 0.2168429770 0.346598592 6 35312302 35312538 237 + 1.058 1.211 0.550
ENSG00000023892 E007 14.315486 0.0015167634 0.0079493887 0.023650792 6 35312626 35312772 147 + 0.814 1.139 1.209
ENSG00000023892 E008 1.190702 0.3162074246 0.1355122056 0.241834084 6 35317608 35317890 283 + 0.539 0.219 -1.909
ENSG00000023892 E009 8.777082 0.0159940930 0.0764505205 0.153820977 6 35317891 35317999 109 + 0.670 0.948 1.096
ENSG00000023892 E010 11.398410 0.0016158087 0.0063125719 0.019435696 6 35318173 35318401 229 + 0.670 1.049 1.468
ENSG00000023892 E011 7.197717 0.0038241618 0.2135127524 0.342672041 6 35318402 35318471 70 + 0.670 0.858 0.755
ENSG00000023892 E012 16.245398 0.0012222395 0.0004170439 0.001839871 6 35318763 35318895 133 + 1.363 1.055 -1.092
ENSG00000023892 E013 28.379637 0.0008021709 0.1175069545 0.216383713 6 35319524 35319690 167 + 1.456 1.347 -0.379
ENSG00000023892 E014 35.390066 0.0012142910 0.0592915861 0.125422165 6 35319819 35320017 199 + 1.556 1.438 -0.406
ENSG00000023892 E015 24.112934 0.0027518141 0.1929107912 0.317427416 6 35320884 35320974 91 + 1.375 1.270 -0.364
ENSG00000023892 E016 60.693582 0.0008894132 0.3890438179 0.533138394 6 35321187 35321771 585 + 1.720 1.680 -0.135