ENSG00000023734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000419869 ENSG00000023734 HEK293_OSMI2_2hA HEK293_TMG_2hB STRAP protein_coding protein_coding 145.6778 125.1031 172.4325 22.0327 4.7111 0.4628817 130.911950 99.257903 159.399408 9.429157 4.2212931 0.6833376 0.89376667 0.81376667 0.924533333 0.11076667 0.109294672 0.005375821 FALSE  
ENST00000538718 ENSG00000023734 HEK293_OSMI2_2hA HEK293_TMG_2hB STRAP protein_coding protein_coding 145.6778 125.1031 172.4325 22.0327 4.7111 0.4628817 3.013746 8.557870 0.473819 2.799666 0.2573466 -4.1463973 0.02317083 0.06530000 0.002666667 -0.06263333 0.005453885 0.005375821    
ENST00000539887 ENSG00000023734 HEK293_OSMI2_2hA HEK293_TMG_2hB STRAP protein_coding retained_intron 145.6778 125.1031 172.4325 22.0327 4.7111 0.4628817 3.250049 9.940014 1.070836 8.055777 0.5249735 -3.2025512 0.02413333 0.06353333 0.006066667 -0.05746667 0.704002333 0.005375821    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000023734 E001 1.338166 0.1291589876 2.394964e-01 3.735326e-01 12 15881722 15882386 665 + 0.477 0.239 -1.448
ENSG00000023734 E002 1.041478 0.0591426351 4.232889e-01 5.663669e-01 12 15882387 15882389 3 + 0.385 0.240 -0.951
ENSG00000023734 E003 3.308200 0.0468197069 6.436524e-01 7.561532e-01 12 15882390 15882390 1 + 0.673 0.597 -0.330
ENSG00000023734 E004 4.493603 0.0773716013 9.402887e-01 9.665012e-01 12 15882391 15882393 3 + 0.746 0.757 0.042
ENSG00000023734 E005 34.706444 0.0156237365 5.127447e-03 1.627565e-02 12 15882394 15882398 5 + 1.650 1.413 -0.812
ENSG00000023734 E006 1364.748555 0.0025865762 7.468784e-11 1.344615e-09 12 15882399 15882819 421 + 3.209 3.041 -0.560
ENSG00000023734 E007 1.650153 0.0383827658 8.444723e-01 9.031960e-01 12 15883083 15883121 39 + 0.433 0.396 -0.197
ENSG00000023734 E008 1053.647749 0.0016295289 1.054486e-08 1.294094e-07 12 15883541 15883676 136 + 3.081 2.954 -0.421
ENSG00000023734 E009 916.670304 0.0014747186 6.401288e-03 1.966633e-02 12 15889928 15890009 82 + 2.992 2.934 -0.193
ENSG00000023734 E010 945.267592 0.0003420631 2.091922e-04 1.003287e-03 12 15890597 15890669 73 + 3.003 2.953 -0.163
ENSG00000023734 E011 931.082324 0.0003661827 7.078274e-01 8.056172e-01 12 15894047 15894143 97 + 2.975 2.972 -0.010
ENSG00000023734 E012 960.503839 0.0004858326 4.162155e-01 5.595945e-01 12 15895359 15895453 95 + 2.991 2.980 -0.038
ENSG00000023734 E013 799.431097 0.0003619862 7.666752e-01 8.490989e-01 12 15895454 15895496 43 + 2.903 2.910 0.023
ENSG00000023734 E014 873.240031 0.0010635332 7.887875e-02 1.577234e-01 12 15897882 15897944 63 + 2.928 2.959 0.103
ENSG00000023734 E015 855.260087 0.0009656075 7.200670e-02 1.466752e-01 12 15897945 15898018 74 + 2.919 2.951 0.109
ENSG00000023734 E016 1.960573 0.0072949187 3.050805e-02 7.296534e-02 12 15898019 15898272 254 + 0.617 0.241 -2.079
ENSG00000023734 E017 1455.031957 0.0005813361 1.124088e-02 3.174029e-02 12 15899904 15900053 150 + 3.148 3.184 0.119
ENSG00000023734 E018 6.106310 0.0039301852 7.906311e-02 1.580136e-01 12 15900899 15900946 48 + 0.953 0.736 -0.843
ENSG00000023734 E019 736.537397 0.0003362834 1.735746e-01 2.928260e-01 12 15900947 15900949 3 + 2.860 2.886 0.085
ENSG00000023734 E020 1142.749251 0.0003327217 1.302427e-01 2.345044e-01 12 15900950 15901012 63 + 3.051 3.075 0.079
ENSG00000023734 E021 524.339028 0.0001650599 4.463279e-02 9.952622e-02 12 15902917 15902919 3 + 2.707 2.745 0.128
ENSG00000023734 E022 2350.700320 0.0018041391 8.599113e-12 1.810688e-10 12 15902920 15903528 609 + 3.303 3.437 0.442