ENSG00000023697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000428559 ENSG00000023697 HEK293_OSMI2_2hA HEK293_TMG_2hB DERA protein_coding protein_coding 14.67286 9.493566 26.30501 1.187344 1.916918 1.469345 11.3652750 8.3396302 18.372159 0.8021167 0.5901794 1.138522 0.8090708 0.88600000 0.70466667 -0.18133333 7.442771e-02 5.841778e-05 FALSE  
ENST00000526521 ENSG00000023697 HEK293_OSMI2_2hA HEK293_TMG_2hB DERA protein_coding nonsense_mediated_decay 14.67286 9.493566 26.30501 1.187344 1.916918 1.469345 2.2223889 0.9822857 5.300204 0.3284192 1.7027796 2.419940 0.1191792 0.09753333 0.19436667 0.09683333 3.522458e-01 5.841778e-05    
ENST00000531803 ENSG00000023697 HEK293_OSMI2_2hA HEK293_TMG_2hB DERA protein_coding protein_coding 14.67286 9.493566 26.30501 1.187344 1.916918 1.469345 0.5386139 0.0000000 2.103628 0.0000000 0.9972159 7.723578 0.0336250 0.00000000 0.08036667 0.08036667 5.841778e-05 5.841778e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000023697 E001 2.3961035 0.0573207074 6.242817e-01 0.740649558 12 15911302 15911328 27 + 0.552 0.472 -0.385
ENSG00000023697 E002 2.7187142 0.0344257787 7.796007e-01 0.858292052 12 15911329 15911331 3 + 0.577 0.540 -0.172
ENSG00000023697 E003 23.7310962 0.0071145865 2.965987e-01 0.437836421 12 15911332 15911358 27 + 1.400 1.327 -0.253
ENSG00000023697 E004 25.1223420 0.0117651555 2.507818e-01 0.386862881 12 15911359 15911362 4 + 1.429 1.337 -0.317
ENSG00000023697 E005 53.8670408 0.0004658379 4.228548e-02 0.095244894 12 15911363 15911414 52 + 1.748 1.663 -0.286
ENSG00000023697 E006 0.7750806 0.0203940120 5.928164e-01 0.715289789 12 15911691 15911753 63 + 0.268 0.175 -0.788
ENSG00000023697 E007 0.1472490 0.0432952635 1.000000e+00   12 15916117 15916316 200 + 0.084 0.000 -8.417
ENSG00000023697 E008 0.0000000       12 15951361 15951457 97 +      
ENSG00000023697 E009 0.0000000       12 15956588 15956746 159 +      
ENSG00000023697 E010 85.8413084 0.0020265057 1.631472e-02 0.043421341 12 15956936 15957033 98 + 1.948 1.856 -0.308
ENSG00000023697 E011 64.4736987 0.0043536237 1.473035e-02 0.039883111 12 15958188 15958239 52 + 1.833 1.712 -0.411
ENSG00000023697 E012 98.1863984 0.0031987441 9.379502e-02 0.181050329 12 15958240 15958335 96 + 1.996 1.939 -0.193
ENSG00000023697 E013 122.9701017 0.0003366533 2.549297e-01 0.391711375 12 15959829 15959924 96 + 2.082 2.064 -0.060
ENSG00000023697 E014 0.1451727 0.0428614033 1.000000e+00   12 15962752 15962812 61 + 0.084 0.000 -8.417
ENSG00000023697 E015 166.3155557 0.0002248395 5.282245e-02 0.114173214 12 15962813 15962947 135 + 2.217 2.183 -0.115
ENSG00000023697 E016 154.5045039 0.0002508048 6.198478e-01 0.737138131 12 15982308 15982436 129 + 2.161 2.194 0.112
ENSG00000023697 E017 0.0000000       12 15985172 15985336 165 +      
ENSG00000023697 E018 124.5769190 0.0003601647 1.729694e-01 0.292054666 12 16032542 16032654 113 + 2.058 2.121 0.211
ENSG00000023697 E019 2.5895509 0.0772028770 1.066700e-01 0.200634446 12 16032655 16033048 394 + 0.624 0.299 -1.693
ENSG00000023697 E020 128.1116501 0.0059383826 5.331173e-01 0.665363179 12 16036232 16036381 150 + 2.075 2.127 0.176
ENSG00000023697 E021 200.0340619 0.0069916410 2.312263e-05 0.000141275 12 16036690 16037381 692 + 2.207 2.400 0.643