ENSG00000023287

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000025008 ENSG00000023287 HEK293_OSMI2_2hA HEK293_TMG_2hB RB1CC1 protein_coding protein_coding 11.56065 1.42588 19.48992 0.1647771 0.720425 3.763461 5.425760 0.6935408 8.540157 0.1761613 0.5331141 3.603245 0.47257500 0.4853667 0.4395000 -0.04586667 9.091760e-01 6.415475e-07 FALSE TRUE
ENST00000435644 ENSG00000023287 HEK293_OSMI2_2hA HEK293_TMG_2hB RB1CC1 protein_coding protein_coding 11.56065 1.42588 19.48992 0.1647771 0.720425 3.763461 1.613369 0.7323395 2.731185 0.1887889 0.8971889 1.884648 0.25849167 0.5146333 0.1390333 -0.37560000 1.547236e-02 6.415475e-07 FALSE TRUE
MSTRG.31498.4 ENSG00000023287 HEK293_OSMI2_2hA HEK293_TMG_2hB RB1CC1 protein_coding   11.56065 1.42588 19.48992 0.1647771 0.720425 3.763461 1.252896 0.0000000 3.055543 0.0000000 0.9080532 8.259999 0.06144167 0.0000000 0.1560333 0.15603333 8.778485e-04 6.415475e-07 FALSE TRUE
MSTRG.31498.5 ENSG00000023287 HEK293_OSMI2_2hA HEK293_TMG_2hB RB1CC1 protein_coding   11.56065 1.42588 19.48992 0.1647771 0.720425 3.763461 2.740805 0.0000000 4.136877 0.0000000 0.6162740 8.695881 0.13085833 0.0000000 0.2128000 0.21280000 6.415475e-07 6.415475e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000023287 E001 0.4355181 0.5623724416 1.000000e+00 1.000000e+00 8 52622458 52622458 1 - 0.109 0.000 -9.292
ENSG00000023287 E002 115.6501022 0.0401289505 5.884966e-10 9.113783e-09 8 52622459 52623328 870 - 1.710 2.377 2.238
ENSG00000023287 E003 53.0183343 0.0004753903 6.731798e-10 1.031311e-08 8 52623329 52623471 143 - 1.443 1.867 1.442
ENSG00000023287 E004 40.0318383 0.0038955633 1.271419e-02 3.523985e-02 8 52623472 52623490 19 - 1.357 1.598 0.828
ENSG00000023287 E005 67.2782060 0.0003535043 9.040151e-06 6.071216e-05 8 52623491 52623583 93 - 1.568 1.867 1.014
ENSG00000023287 E006 74.8804420 0.0003512906 7.742839e-10 1.172642e-08 8 52623584 52623713 130 - 1.600 1.971 1.254
ENSG00000023287 E007 42.2769820 0.0004843543 5.532892e-06 3.899806e-05 8 52623714 52623727 14 - 1.359 1.722 1.245
ENSG00000023287 E008 72.5246357 0.0003373402 3.963788e-08 4.363069e-07 8 52623728 52623859 132 - 1.589 1.933 1.165
ENSG00000023287 E009 50.4732612 0.0004773291 1.668672e-04 8.217228e-04 8 52624717 52624787 71 - 1.446 1.740 1.002
ENSG00000023287 E010 15.8264236 0.0011116812 2.998241e-01 4.414077e-01 8 52628032 52628040 9 - 0.993 1.153 0.578
ENSG00000023287 E011 78.9137320 0.0003543603 5.395922e-03 1.700338e-02 8 52628041 52628168 128 - 1.652 1.847 0.661
ENSG00000023287 E012 53.9148153 0.0005403512 3.413233e-03 1.147620e-02 8 52630470 52630528 59 - 1.488 1.722 0.799
ENSG00000023287 E013 57.5821785 0.0004178722 8.973932e-02 1.747314e-01 8 52634921 52634968 48 - 1.524 1.674 0.512
ENSG00000023287 E014 55.7299965 0.0004877682 5.276421e-01 6.606634e-01 8 52636015 52636069 55 - 1.520 1.597 0.262
ENSG00000023287 E015 120.4469948 0.0002739606 6.074338e-03 1.880704e-02 8 52642351 52642591 241 - 1.836 2.000 0.553
ENSG00000023287 E016 84.9047475 0.0003574366 2.267036e-01 3.584582e-01 8 52642704 52642812 109 - 1.694 1.797 0.347
ENSG00000023287 E017 0.0000000       8 52642813 52643243 431 -      
ENSG00000023287 E018 94.7800424 0.0004250244 7.534487e-02 1.520712e-01 8 52645702 52645867 166 - 1.737 1.867 0.440
ENSG00000023287 E019 509.0994903 0.0140390818 1.130365e-01 2.099675e-01 8 52656008 52657884 1877 - 2.481 2.436 -0.150
ENSG00000023287 E020 45.5655277 0.0044958298 3.505406e-02 8.175310e-02 8 52657885 52657908 24 - 1.459 1.270 -0.659
ENSG00000023287 E021 75.8926403 0.0020471059 4.064410e-03 1.332232e-02 8 52657998 52658124 127 - 1.675 1.472 -0.692
ENSG00000023287 E022 63.2736438 0.0003777665 2.232173e-03 7.942871e-03 8 52658873 52658976 104 - 1.600 1.362 -0.816
ENSG00000023287 E023 38.1207328 0.0005857007 1.128899e-01 2.097663e-01 8 52660596 52660657 62 - 1.380 1.243 -0.477
ENSG00000023287 E024 56.3248090 0.0004323404 2.379151e-03 8.395855e-03 8 52660926 52661007 82 - 1.550 1.295 -0.880
ENSG00000023287 E025 76.0793096 0.0003698499 4.029565e-04 1.785998e-03 8 52661095 52661281 187 - 1.677 1.420 -0.879
ENSG00000023287 E026 78.4660944 0.0017325853 1.370372e-06 1.104829e-05 8 52661535 52661719 185 - 1.699 1.295 -1.390
ENSG00000023287 E027 80.6829617 0.0007774054 7.025029e-06 4.837243e-05 8 52668021 52668191 171 - 1.709 1.362 -1.190
ENSG00000023287 E028 149.0357114 0.0003786334 2.701018e-16 1.103277e-14 8 52673845 52674274 430 - 1.977 1.438 -1.829
ENSG00000023287 E029 72.7640982 0.0004636414 2.635080e-04 1.230970e-03 8 52676369 52676571 203 - 1.659 1.382 -0.949
ENSG00000023287 E030 41.1158695 0.0005248960 3.946032e-04 1.753920e-03 8 52683549 52683603 55 - 1.425 1.038 -1.369
ENSG00000023287 E031 36.5289855 0.0008604501 8.497279e-04 3.436698e-03 8 52683604 52683634 31 - 1.377 0.992 -1.372
ENSG00000023287 E032 38.4222215 0.0008945870 6.125486e-06 4.275338e-05 8 52683635 52683687 53 - 1.405 0.813 -2.150
ENSG00000023287 E033 28.9082853 0.0063310492 9.219085e-04 3.691687e-03 8 52683688 52683719 32 - 1.285 0.813 -1.731
ENSG00000023287 E034 48.9056427 0.0004603480 1.591798e-07 1.555241e-06 8 52683887 52683949 63 - 1.507 0.881 -2.239
ENSG00000023287 E035 45.6007357 0.0004598474 7.897081e-07 6.705563e-06 8 52683950 52684013 64 - 1.478 0.881 -2.137
ENSG00000023287 E036 32.2867742 0.0006151505 4.214305e-04 1.856475e-03 8 52685399 52685423 25 - 1.330 0.881 -1.627
ENSG00000023287 E037 44.1937951 0.0004817093 7.324908e-06 5.019285e-05 8 52685424 52685520 97 - 1.462 0.940 -1.861
ENSG00000023287 E038 1.0542652 0.4928094429 1.000000e+00 1.000000e+00 8 52685937 52686156 220 - 0.225 0.000 -10.349
ENSG00000023287 E039 43.2045159 0.0004829162 5.199326e-07 4.583512e-06 8 52686853 52686945 93 - 1.455 0.813 -2.322
ENSG00000023287 E040 22.0960277 0.0012327019 7.334625e-04 3.019651e-03 8 52686946 52686967 22 - 1.177 0.634 -2.089
ENSG00000023287 E041 49.8165394 0.0051883197 7.679432e-06 5.237402e-05 8 52714075 52714466 392 - 1.511 0.992 -1.835
ENSG00000023287 E042 0.0000000       8 52745549 52745843 295 -