ENSG00000022567

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000024061 ENSG00000022567 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC45A4 protein_coding protein_coding 5.236047 5.36959 5.647383 0.2650214 0.1823924 0.07263854 0.4389044 0.3298124 0.9935613 0.32981241 0.25360568 1.5623183 0.08159167 0.06813333 0.1777000 0.1095667 2.348063e-01 1.227661e-26 FALSE TRUE
ENST00000517878 ENSG00000022567 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC45A4 protein_coding protein_coding 5.236047 5.36959 5.647383 0.2650214 0.1823924 0.07263854 1.3573744 0.9132313 1.9424259 0.06953478 0.03644703 1.0805037 0.25626667 0.16966667 0.3443000 0.1746333 2.313925e-05 1.227661e-26 FALSE TRUE
ENST00000519067 ENSG00000022567 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC45A4 protein_coding protein_coding 5.236047 5.36959 5.647383 0.2650214 0.1823924 0.07263854 0.8612954 2.0146523 0.0000000 0.05324424 0.00000000 -7.6615304 0.17162083 0.37816667 0.0000000 -0.3781667 1.227661e-26 1.227661e-26 FALSE TRUE
MSTRG.32147.8 ENSG00000022567 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC45A4 protein_coding   5.236047 5.36959 5.647383 0.2650214 0.1823924 0.07263854 1.6926486 1.5380819 2.1496937 0.45156058 0.21177936 0.4803449 0.32082500 0.28026667 0.3802667 0.1000000 5.570495e-01 1.227661e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000022567 E001 0.2955422 0.0287263417 8.527611e-01   8 141207166 141207173 8 - 0.136 0.110 -0.360
ENSG00000022567 E002 6.8504063 0.0024331558 3.678335e-02 8.505427e-02 8 141207174 141207228 55 - 0.703 0.970 1.041
ENSG00000022567 E003 8.9871926 0.0019018012 4.176014e-03 1.363906e-02 8 141207229 141207267 39 - 0.763 1.097 1.264
ENSG00000022567 E004 7.9187624 0.0023179303 1.094414e-02 3.102820e-02 8 141207268 141207275 8 - 0.734 1.044 1.186
ENSG00000022567 E005 7.7704692 0.0023040712 1.474815e-02 3.992216e-02 8 141207276 141207285 10 - 0.734 1.032 1.145
ENSG00000022567 E006 10.4190315 0.0016734809 8.288097e-04 3.362004e-03 8 141207286 141207325 40 - 0.789 1.162 1.390
ENSG00000022567 E007 175.5872312 0.0040897801 5.409132e-06 3.820535e-05 8 141207326 141209567 2242 - 2.120 2.300 0.601
ENSG00000022567 E008 63.1897121 0.0004348284 1.109679e-01 2.069656e-01 8 141209568 141210600 1033 - 1.833 1.765 -0.228
ENSG00000022567 E009 75.7553391 0.0031756334 1.621580e-01 2.779268e-01 8 141210601 141210992 392 - 1.833 1.904 0.239
ENSG00000022567 E010 129.8826870 0.0024925208 3.498387e-02 8.162256e-02 8 141210993 141211462 470 - 2.052 2.136 0.282
ENSG00000022567 E011 39.6355260 0.0106018118 1.674929e-01 2.849384e-01 8 141211463 141211493 31 - 1.524 1.632 0.367
ENSG00000022567 E012 48.0404105 0.0097348523 2.632794e-01 4.011605e-01 8 141211494 141211634 141 - 1.622 1.705 0.281
ENSG00000022567 E013 30.7818797 0.0040344212 2.602542e-02 6.399759e-02 8 141211635 141211697 63 - 1.377 1.538 0.554
ENSG00000022567 E014 61.1201719 0.0103057387 4.015509e-03 1.318508e-02 8 141211698 141212185 488 - 1.648 1.845 0.666
ENSG00000022567 E015 27.2040448 0.0011090946 7.337594e-02 1.489207e-01 8 141212186 141212196 11 - 1.357 1.482 0.433
ENSG00000022567 E016 32.4431531 0.0103294277 6.394890e-01 7.528681e-01 8 141212197 141212203 7 - 1.489 1.524 0.119
ENSG00000022567 E017 113.9433574 0.0002821088 4.316699e-03 1.403153e-02 8 141212204 141212556 353 - 2.101 2.012 -0.299
ENSG00000022567 E018 85.0017448 0.0032281892 9.088844e-03 2.650271e-02 8 141215759 141215970 212 - 1.992 1.879 -0.379
ENSG00000022567 E019 50.1577390 0.0026791115 1.776424e-01 2.981715e-01 8 141217090 141217189 100 - 1.742 1.672 -0.237
ENSG00000022567 E020 129.9758933 0.0043400518 1.724729e-02 4.549432e-02 8 141218011 141218773 763 - 2.161 2.064 -0.322
ENSG00000022567 E021 51.3973624 0.0010229862 2.206666e-03 7.863186e-03 8 141218774 141219029 256 - 1.791 1.642 -0.504
ENSG00000022567 E022 31.5642737 0.0006889502 5.942393e-03 1.845704e-02 8 141219650 141219746 97 - 1.594 1.429 -0.566
ENSG00000022567 E023 24.8166446 0.0008783358 1.045983e-01 1.975106e-01 8 141219747 141219829 83 - 1.462 1.353 -0.376
ENSG00000022567 E024 33.4311263 0.0006134470 4.458378e-03 1.442548e-02 8 141221577 141221765 189 - 1.618 1.452 -0.569
ENSG00000022567 E025 0.2214452 0.0380648937 6.092599e-01   8 141228179 141228574 396 - 0.000 0.110 8.363
ENSG00000022567 E026 0.0000000       8 141230079 141230348 270 -      
ENSG00000022567 E027 24.4502737 0.0101046068 1.892727e-01 3.128213e-01 8 141253989 141254100 112 - 1.445 1.341 -0.361
ENSG00000022567 E028 51.9421225 0.0317938725 2.054508e-02 5.264144e-02 8 141254101 141254629 529 - 1.832 1.610 -0.751
ENSG00000022567 E029 0.4751703 0.0220820020 7.238632e-01 8.175861e-01 8 141296206 141296267 62 - 0.136 0.197 0.641
ENSG00000022567 E030 0.8481309 0.0143774108 8.694181e-01 9.200599e-01 8 141299399 141299532 134 - 0.240 0.270 0.228
ENSG00000022567 E031 0.5483223 0.0211561972 7.214161e-01 8.158144e-01 8 141299768 141299832 65 - 0.136 0.198 0.645
ENSG00000022567 E032 10.1111353 0.0568776307 1.480883e-03 5.575296e-03 8 141308096 141308332 237 - 1.262 0.775 -1.803