ENSG00000022267

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370683 ENSG00000022267 HEK293_OSMI2_2hA HEK293_TMG_2hB FHL1 protein_coding protein_coding 87.73689 115.2315 86.44664 6.238005 1.516218 -0.4146118 3.394124 15.55308 0.1217212 8.425566 0.1217212 -6.8844960 0.03070417 0.1303000 0.001466667 -0.1288333 2.276398e-03 4.8207e-23 FALSE TRUE
ENST00000618438 ENSG00000022267 HEK293_OSMI2_2hA HEK293_TMG_2hB FHL1 protein_coding protein_coding 87.73689 115.2315 86.44664 6.238005 1.516218 -0.4146118 5.753397 10.32771 4.4330970 1.664173 0.4118412 -1.2182789 0.06175833 0.0891000 0.051500000 -0.0376000 6.255001e-02 4.8207e-23 FALSE TRUE
ENST00000628032 ENSG00000022267 HEK293_OSMI2_2hA HEK293_TMG_2hB FHL1 protein_coding protein_coding 87.73689 115.2315 86.44664 6.238005 1.516218 -0.4146118 7.551894 0.00000 13.5266967 0.000000 3.2104090 10.4026600 0.09810000 0.0000000 0.155300000 0.1553000 4.820700e-23 4.8207e-23 FALSE FALSE
ENST00000651929 ENSG00000022267 HEK293_OSMI2_2hA HEK293_TMG_2hB FHL1 protein_coding protein_coding 87.73689 115.2315 86.44664 6.238005 1.516218 -0.4146118 58.749000 77.08569 57.3308386 7.910479 1.2043558 -0.4270871 0.66187500 0.6754667 0.664066667 -0.0114000 9.457201e-01 4.8207e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000022267 E001 0.1482932 0.0410864152 7.504270e-01   X 136146702 136147012 311 + 0.000 0.106 9.328
ENSG00000022267 E002 18.8818789 0.0170795759 7.222904e-07 6.185506e-06 X 136147465 136147532 68 + 1.498 1.074 -1.487
ENSG00000022267 E003 18.9905053 0.0192656253 1.557625e-06 1.240384e-05 X 136147533 136147535 3 + 1.498 1.076 -1.482
ENSG00000022267 E004 29.0914688 0.0056240573 3.156149e-09 4.265090e-08 X 136147536 136147541 6 + 1.652 1.293 -1.234
ENSG00000022267 E005 196.1891546 0.0066234901 3.032671e-04 1.392700e-03 X 136147542 136147628 87 + 2.338 2.241 -0.323
ENSG00000022267 E006 1.1310007 0.0912891232 8.024582e-01 8.741593e-01 X 136147660 136147665 6 + 0.331 0.324 -0.043
ENSG00000022267 E007 3.4236586 0.0526281808 4.247870e-01 5.677302e-01 X 136147666 136147878 213 + 0.683 0.608 -0.321
ENSG00000022267 E008 0.0000000       X 136148083 136148146 64 +      
ENSG00000022267 E009 0.0000000       X 136148229 136148263 35 +      
ENSG00000022267 E010 0.0000000       X 136148440 136148490 51 +      
ENSG00000022267 E011 0.0000000       X 136148578 136148737 160 +      
ENSG00000022267 E012 0.1515154 0.0433923663 3.070372e-01   X 136154066 136154150 85 + 0.140 0.000 -11.639
ENSG00000022267 E013 0.2214452 0.0442925664 7.470046e-01   X 136160474 136160569 96 + 0.000 0.107 10.634
ENSG00000022267 E014 0.0000000       X 136167004 136167008 5 +      
ENSG00000022267 E015 0.0000000       X 136167009 136167014 6 +      
ENSG00000022267 E016 0.0000000       X 136167015 136167050 36 +      
ENSG00000022267 E017 0.0000000       X 136167051 136167077 27 +      
ENSG00000022267 E018 0.0000000       X 136167078 136167098 21 +      
ENSG00000022267 E019 0.0000000       X 136167845 136167903 59 +      
ENSG00000022267 E020 0.0000000       X 136167904 136168035 132 +      
ENSG00000022267 E021 0.0000000       X 136168130 136168193 64 +      
ENSG00000022267 E022 0.0000000       X 136168194 136168267 74 +      
ENSG00000022267 E023 0.0000000       X 136168268 136168288 21 +      
ENSG00000022267 E024 0.3686942 0.0312411719 7.221948e-01 8.163723e-01 X 136169296 136169636 341 + 0.140 0.107 -0.454
ENSG00000022267 E025 1.4531484 0.0137553052 1.691248e-02 4.474135e-02 X 136169637 136169675 39 + 0.565 0.192 -2.263
ENSG00000022267 E026 5.4765023 0.0030563572 7.588957e-05 4.085782e-04 X 136169676 136169733 58 + 1.023 0.577 -1.779
ENSG00000022267 E027 8.3247334 0.0021097705 1.943888e-06 1.516237e-05 X 136169734 136169838 105 + 1.190 0.736 -1.706
ENSG00000022267 E028 7.5153098 0.0024611161 2.106504e-05 1.299646e-04 X 136169839 136169865 27 + 1.133 0.713 -1.595
ENSG00000022267 E029 9.0849360 0.0018865425 2.814077e-05 1.684685e-04 X 136169866 136169890 25 + 1.190 0.816 -1.384
ENSG00000022267 E030 9.5696857 0.0017925730 2.820075e-06 2.123881e-05 X 136169891 136169906 16 + 1.231 0.816 -1.528
ENSG00000022267 E031 345.7533399 0.0029068455 2.940657e-05 1.753481e-04 X 136169907 136169980 74 + 2.563 2.502 -0.202
ENSG00000022267 E032 0.9275265 0.0146514313 1.590299e-01 2.738288e-01 X 136182724 136182865 142 + 0.402 0.192 -1.458
ENSG00000022267 E033 0.0000000       X 136196757 136196863 107 +      
ENSG00000022267 E034 0.0000000       X 136197026 136197046 21 +      
ENSG00000022267 E035 0.0000000       X 136197047 136197052 6 +      
ENSG00000022267 E036 0.1451727 0.0435284960 3.073416e-01   X 136197053 136197062 10 + 0.140 0.000 -11.637
ENSG00000022267 E037 3.2762790 0.0053367848 3.700498e-02 8.548120e-02 X 136197063 136197134 72 + 0.331 0.736 1.958
ENSG00000022267 E038 0.0000000       X 136204721 136204908 188 +      
ENSG00000022267 E039 0.0000000       X 136204909 136204939 31 +      
ENSG00000022267 E040 0.0000000       X 136206102 136206207 106 +      
ENSG00000022267 E041 387.3274332 0.0017225688 7.574126e-07 6.458838e-06 X 136206407 136206464 58 + 2.611 2.553 -0.192
ENSG00000022267 E042 635.6894683 0.0002373083 3.065565e-06 2.288537e-05 X 136206465 136206588 124 + 2.789 2.794 0.014
ENSG00000022267 E043 846.7867406 0.0001567963 1.016875e-10 1.791870e-09 X 136207016 136207190 175 + 2.921 2.914 -0.023
ENSG00000022267 E044 3.8257378 0.0042279154 3.404380e-01 4.843928e-01 X 136207191 136207395 205 + 0.715 0.637 -0.331
ENSG00000022267 E045 2.5002862 0.0066308702 3.297657e-01 4.732991e-01 X 136207396 136207430 35 + 0.607 0.508 -0.459
ENSG00000022267 E046 3.3410182 0.0576648272 6.365317e-02 1.327832e-01 X 136207431 136207661 231 + 0.775 0.508 -1.155
ENSG00000022267 E047 1020.7749561 0.0001035320 8.391908e-13 2.086928e-11 X 136207792 136207961 170 + 3.001 2.997 -0.016
ENSG00000022267 E048 932.5323943 0.0014935600 2.417877e-02 6.017597e-02 X 136208455 136208641 187 + 2.940 2.968 0.093
ENSG00000022267 E049 10.1392748 0.0335551058 5.727459e-01 6.988239e-01 X 136209168 136209242 75 + 1.037 1.023 -0.052
ENSG00000022267 E050 24.1846288 0.0008790465 2.928753e-01 4.338952e-01 X 136209243 136209339 97 + 1.392 1.391 -0.002
ENSG00000022267 E051 26.3490476 0.0007499303 9.777271e-01 9.901717e-01 X 136209340 136209442 103 + 1.378 1.451 0.251
ENSG00000022267 E052 4084.6836939 0.0024946072 1.353174e-15 5.032483e-14 X 136209871 136211359 1489 + 3.471 3.659 0.627