ENSG00000021826

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000430249 ENSG00000021826 HEK293_OSMI2_2hA HEK293_TMG_2hB CPS1 protein_coding protein_coding 9.182359 6.223698 11.03525 1.213922 0.5209381 0.8252666 2.1143209 1.2246414 2.441674 0.3612948 1.4427888 0.9896748 0.19842083 0.21800000 0.21086667 -0.007133333 9.182127e-01 7.184853e-13 FALSE TRUE
ENST00000645825 ENSG00000021826 HEK293_OSMI2_2hA HEK293_TMG_2hB CPS1 protein_coding processed_transcript 9.182359 6.223698 11.03525 1.213922 0.5209381 0.8252666 0.8212156 2.2132753 0.000000 0.8185702 0.0000000 -7.7965428 0.12210833 0.34800000 0.00000000 -0.348000000 7.184853e-13 7.184853e-13 FALSE TRUE
ENST00000673510 ENSG00000021826 HEK293_OSMI2_2hA HEK293_TMG_2hB CPS1 protein_coding protein_coding 9.182359 6.223698 11.03525 1.213922 0.5209381 0.8252666 3.4338803 0.9925934 4.672951 0.2309255 0.1830905 2.2236813 0.34314583 0.16756667 0.42556667 0.258000000 2.400633e-03 7.184853e-13 FALSE TRUE
ENST00000673630 ENSG00000021826 HEK293_OSMI2_2hA HEK293_TMG_2hB CPS1 protein_coding protein_coding 9.182359 6.223698 11.03525 1.213922 0.5209381 0.8252666 1.5463038 0.3287035 2.303507 0.2513870 0.4489547 2.7719871 0.16237917 0.05170000 0.21293333 0.161233333 1.370191e-01 7.184853e-13 FALSE TRUE
ENST00000673711 ENSG00000021826 HEK293_OSMI2_2hA HEK293_TMG_2hB CPS1 protein_coding protein_coding 9.182359 6.223698 11.03525 1.213922 0.5209381 0.8252666 0.5424725 0.3724870 0.904934 0.3724870 0.9049340 1.2582569 0.07612083 0.04433333 0.08716667 0.042833333 9.265474e-01 7.184853e-13 FALSE TRUE
ENST00000674074 ENSG00000021826 HEK293_OSMI2_2hA HEK293_TMG_2hB CPS1 protein_coding processed_transcript 9.182359 6.223698 11.03525 1.213922 0.5209381 0.8252666 0.1224337 0.8131205 0.000000 0.5087854 0.0000000 -6.3630318 0.01876667 0.12413333 0.00000000 -0.124133333 9.885027e-02 7.184853e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000021826 E001 8.1244210 0.0020675116 3.151825e-03 1.071269e-02 2 210477682 210477708 27 + 1.034 0.651 -1.498
ENSG00000021826 E002 25.4721737 0.0008320146 5.217161e-05 2.926179e-04 2 210477709 210477766 58 + 1.484 1.173 -1.083
ENSG00000021826 E003 25.2596766 0.0007659156 5.085980e-07 4.493628e-06 2 210519551 210519670 120 + 1.499 1.094 -1.419
ENSG00000021826 E004 10.1231245 0.0526465264 1.295990e-02 3.581693e-02 2 210519671 210519784 114 + 1.126 0.737 -1.470
ENSG00000021826 E005 1.4812505 0.0091320969 1.409573e-02 3.844283e-02 2 210549967 210550021 55 + 0.496 0.000 -13.703
ENSG00000021826 E006 0.1515154 0.0443710361 1.000000e+00   2 210556599 210556718 120 + 0.084 0.000 -10.382
ENSG00000021826 E007 51.5600066 0.0229248421 4.414268e-03 1.430401e-02 2 210556719 210556859 141 + 1.771 1.514 -0.875
ENSG00000021826 E008 44.2093455 0.0370085899 5.649167e-03 1.768341e-02 2 210573298 210573407 110 + 1.714 1.430 -0.970
ENSG00000021826 E009 58.5511164 0.0243753744 2.660466e-03 9.254138e-03 2 210576346 210576490 145 + 1.828 1.566 -0.888
ENSG00000021826 E010 0.0000000       2 210577155 210577420 266 +      
ENSG00000021826 E011 46.4952021 0.0004929802 5.632054e-08 6.000313e-07 2 210577421 210577510 90 + 1.740 1.428 -1.065
ENSG00000021826 E012 41.9137523 0.0005058030 2.236765e-05 1.371310e-04 2 210579714 210579770 57 + 1.683 1.436 -0.843
ENSG00000021826 E013 0.0000000       2 210579771 210579800 30 +      
ENSG00000021826 E014 44.4599573 0.0007497763 1.827655e-04 8.897438e-04 2 210582617 210582709 93 + 1.698 1.488 -0.715
ENSG00000021826 E015 39.7917164 0.0280105216 3.807487e-02 8.748964e-02 2 210588058 210588147 90 + 1.649 1.439 -0.719
ENSG00000021826 E016 49.6636094 0.0129087481 2.189320e-03 7.808865e-03 2 210590106 210590234 129 + 1.750 1.515 -0.801
ENSG00000021826 E017 42.0984290 0.0123031516 4.117323e-03 1.347199e-02 2 210590800 210590906 107 + 1.680 1.450 -0.784
ENSG00000021826 E018 46.2043073 0.0061967289 2.063893e-02 5.282619e-02 2 210591831 210591969 139 + 1.700 1.551 -0.507
ENSG00000021826 E019 38.8888856 0.0005331980 4.137114e-05 2.376426e-04 2 210592879 210592956 78 + 1.651 1.403 -0.847
ENSG00000021826 E020 0.0000000       2 210593355 210593365 11 +      
ENSG00000021826 E021 0.0000000       2 210593366 210593674 309 +      
ENSG00000021826 E022 42.1981805 0.0009809030 5.048192e-05 2.842264e-04 2 210594508 210594606 99 + 1.683 1.444 -0.816
ENSG00000021826 E023 38.9610691 0.0005546701 5.635563e-06 3.964502e-05 2 210595487 210595582 96 + 1.657 1.377 -0.959
ENSG00000021826 E024 59.0789985 0.0004278235 3.629121e-05 2.112994e-04 2 210599372 210599532 161 + 1.817 1.620 -0.669
ENSG00000021826 E025 30.3545643 0.0293594941 1.188759e-01 2.183359e-01 2 210599533 210599561 29 + 1.528 1.362 -0.572
ENSG00000021826 E026 58.7607223 0.0062450846 6.678571e-02 1.380392e-01 2 210600555 210600712 158 + 1.791 1.692 -0.337
ENSG00000021826 E027 51.5985460 0.0004644078 3.734261e-01 5.178836e-01 2 210602202 210602330 129 + 1.714 1.682 -0.108
ENSG00000021826 E028 0.0000000       2 210604965 210605101 137 +      
ENSG00000021826 E029 54.4860080 0.0006276413 7.223500e-02 1.470548e-01 2 210605102 210605246 145 + 1.752 1.673 -0.267
ENSG00000021826 E030 75.9549512 0.0080028588 7.360006e-01 8.266279e-01 2 210606731 210606941 211 + 1.871 1.856 -0.050
ENSG00000021826 E031 78.1496215 0.0057443955 6.851545e-02 1.409144e-01 2 210608361 210608559 199 + 1.909 1.812 -0.326
ENSG00000021826 E032 66.8417471 0.0019867699 3.154985e-01 4.582799e-01 2 210612117 210612293 177 + 1.826 1.788 -0.126
ENSG00000021826 E033 60.3503818 0.0008114814 9.728316e-01 9.870343e-01 2 210616423 210616541 119 + 1.763 1.778 0.051
ENSG00000021826 E034 0.0000000       2 210631228 210631286 59 +      
ENSG00000021826 E035 65.5526899 0.0006860450 7.159475e-01 8.117234e-01 2 210637702 210637843 142 + 1.806 1.803 -0.011
ENSG00000021826 E036 39.8037623 0.0006477359 7.074349e-01 8.053543e-01 2 210639150 210639215 66 + 1.596 1.588 -0.027
ENSG00000021826 E037 40.5722861 0.0005574579 7.203188e-01 8.149529e-01 2 210639996 210640059 64 + 1.605 1.599 -0.021
ENSG00000021826 E038 70.5075137 0.0003615214 1.485708e-02 4.016779e-02 2 210642484 210642665 182 + 1.794 1.913 0.401
ENSG00000021826 E039 74.9361816 0.0003239684 3.285223e-03 1.110691e-02 2 210647863 210648057 195 + 1.814 1.951 0.459
ENSG00000021826 E040 47.2850416 0.0006870892 5.274720e-01 6.605412e-01 2 210648473 210648540 68 + 1.655 1.704 0.166
ENSG00000021826 E041 51.2486593 0.0088787756 9.056426e-01 9.439709e-01 2 210650363 210650438 76 + 1.700 1.714 0.048
ENSG00000021826 E042 0.2924217 0.0276890705 5.641577e-01   2 210653737 210653879 143 + 0.154 0.000 -11.381
ENSG00000021826 E043 54.3959572 0.0004928220 7.472845e-01 8.348219e-01 2 210654025 210654102 78 + 1.730 1.729 -0.004
ENSG00000021826 E044 59.1584513 0.0004166491 1.478112e-01 2.587075e-01 2 210656525 210656632 108 + 1.733 1.816 0.279
ENSG00000021826 E045 0.2955422 0.0284804524 5.505002e-01   2 210657360 210657655 296 + 0.084 0.175 1.215
ENSG00000021826 E046 0.0000000       2 210658194 210658228 35 +      
ENSG00000021826 E047 0.1515154 0.0443710361 1.000000e+00   2 210658383 210658598 216 + 0.084 0.000 -10.382
ENSG00000021826 E048 55.7742192 0.0070301486 4.372441e-01 5.792345e-01 2 210658599 210658688 90 + 1.716 1.780 0.218
ENSG00000021826 E049 84.1282414 0.0060705044 7.255050e-01 8.187473e-01 2 210660485 210660655 171 + 1.902 1.941 0.132
ENSG00000021826 E050 71.5542194 0.0086106862 9.982986e-01 1.000000e+00 2 210663123 210663197 75 + 1.838 1.860 0.074
ENSG00000021826 E051 0.1515154 0.0443710361 1.000000e+00   2 210665538 210665687 150 + 0.084 0.000 -10.382
ENSG00000021826 E052 63.6261269 0.0004943237 1.668025e-02 4.423574e-02 2 210668186 210668284 99 + 1.749 1.871 0.415
ENSG00000021826 E053 0.8051678 0.0144994947 2.516638e-02 6.222158e-02 2 210671615 210674901 3287 + 0.084 0.475 3.216
ENSG00000021826 E054 54.0511162 0.0006210950 3.020365e-03 1.032631e-02 2 210674902 210674961 60 + 1.663 1.822 0.540
ENSG00000021826 E055 70.6393829 0.0003635320 8.251248e-07 6.976899e-06 2 210675728 210675840 113 + 1.752 1.974 0.748
ENSG00000021826 E056 65.7740801 0.0003668456 9.804569e-06 6.532024e-05 2 210677007 210677136 130 + 1.728 1.936 0.700
ENSG00000021826 E057 274.7699382 0.0034114800 3.486178e-40 1.225317e-37 2 210677887 210679107 1221 + 2.218 2.660 1.473