ENSG00000021776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000156471 ENSG00000021776 HEK293_OSMI2_2hA HEK293_TMG_2hB AQR protein_coding protein_coding 11.32251 5.186064 16.56555 0.5596326 0.29264 1.673565 1.9368481 0.8026242 3.18449811 0.1033341 0.07065209 1.974929 0.17356250 0.1541000 0.1923667 0.03826667 4.239773e-01 5.827783e-05 FALSE TRUE
ENST00000559767 ENSG00000021776 HEK293_OSMI2_2hA HEK293_TMG_2hB AQR protein_coding retained_intron 11.32251 5.186064 16.56555 0.5596326 0.29264 1.673565 0.8859136 1.8991650 0.07822176 0.5644022 0.07822176 -4.435663 0.13670417 0.3577000 0.0046000 -0.35310000 5.827783e-05 5.827783e-05 FALSE FALSE
MSTRG.10462.2 ENSG00000021776 HEK293_OSMI2_2hA HEK293_TMG_2hB AQR protein_coding   11.32251 5.186064 16.56555 0.5596326 0.29264 1.673565 0.6444607 0.6206763 0.22090590 0.3532704 0.22090590 -1.449595 0.05809583 0.1124333 0.0133000 -0.09913333 3.723478e-01 5.827783e-05 TRUE TRUE
MSTRG.10462.3 ENSG00000021776 HEK293_OSMI2_2hA HEK293_TMG_2hB AQR protein_coding   11.32251 5.186064 16.56555 0.5596326 0.29264 1.673565 7.2725951 1.7497999 12.26724463 0.2018791 0.22809121 2.802504 0.57889583 0.3542333 0.7407667 0.38653333 3.059072e-04 5.827783e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000021776 E001 3.7037620 0.0152023517 2.830385e-02 6.861265e-02 15 34851782 34851843 62 - 0.520 0.869 1.469
ENSG00000021776 E002 13.8142919 0.0015328482 2.400315e-05 1.462392e-04 15 34851844 34852026 183 - 0.981 1.382 1.429
ENSG00000021776 E003 11.0347469 0.0062000663 1.206023e-04 6.167732e-04 15 34852027 34852067 41 - 0.890 1.305 1.504
ENSG00000021776 E004 198.6989551 0.0002392833 3.024951e-01 4.443627e-01 15 34852068 34856350 4283 - 2.238 2.215 -0.078
ENSG00000021776 E005 11.6294010 0.0016449250 6.212853e-01 7.382522e-01 15 34856351 34856499 149 - 1.050 1.000 -0.186
ENSG00000021776 E006 44.4832301 0.0006212805 2.097134e-12 4.880784e-11 15 34856500 34856743 244 - 1.465 1.859 1.337
ENSG00000021776 E007 31.3714360 0.0008054155 7.498145e-07 6.398077e-06 15 34856744 34856749 6 - 1.341 1.674 1.142
ENSG00000021776 E008 76.1377452 0.0055043131 8.379405e-08 8.637321e-07 15 34856750 34856826 77 - 1.729 2.031 1.016
ENSG00000021776 E009 164.9730618 0.0066319983 4.073931e-09 5.393012e-08 15 34856827 34857106 280 - 2.066 2.353 0.957
ENSG00000021776 E010 92.5610544 0.0019090069 3.240107e-08 3.624615e-07 15 34860042 34860155 114 - 1.832 2.082 0.838
ENSG00000021776 E011 96.2338300 0.0057808109 7.725989e-03 2.309130e-02 15 34862867 34863041 175 - 1.881 2.031 0.503
ENSG00000021776 E012 0.2966881 0.0271134549 1.000000e+00   15 34863042 34863224 183 - 0.124 0.000 -10.488
ENSG00000021776 E013 57.5003182 0.0004651709 1.111856e-03 4.343406e-03 15 34867524 34867609 86 - 1.652 1.827 0.592
ENSG00000021776 E014 13.0537390 0.0013013171 3.967080e-03 1.305049e-02 15 34867610 34870264 2655 - 1.147 0.788 -1.343
ENSG00000021776 E015 86.1094052 0.0016108042 1.285501e-04 6.525745e-04 15 34870752 34870922 171 - 1.822 2.002 0.607
ENSG00000021776 E016 97.1757403 0.0029244278 2.747066e-02 6.694926e-02 15 34873828 34873999 172 - 1.893 2.003 0.367
ENSG00000021776 E017 4.0844042 0.0052119012 1.919967e-01 3.162661e-01 15 34874000 34874676 677 - 0.695 0.466 -1.039
ENSG00000021776 E018 108.0768662 0.0037084427 7.193657e-01 8.142345e-01 15 34874677 34874864 188 - 1.963 1.985 0.076
ENSG00000021776 E019 69.6502750 0.0030255462 8.866679e-01 9.315213e-01 15 34875935 34876006 72 - 1.777 1.792 0.049
ENSG00000021776 E020 79.9978313 0.0003468818 4.865124e-01 6.242423e-01 15 34882502 34882639 138 - 1.831 1.870 0.132
ENSG00000021776 E021 92.3125031 0.0017869133 6.914927e-01 7.929568e-01 15 34884525 34884734 210 - 1.905 1.892 -0.042
ENSG00000021776 E022 76.5243826 0.0003664860 1.774472e-01 2.979371e-01 15 34886526 34886661 136 - 1.833 1.774 -0.200
ENSG00000021776 E023 81.3303814 0.0003981125 8.432512e-02 1.663436e-01 15 34890215 34890324 110 - 1.864 1.788 -0.256
ENSG00000021776 E024 82.4749921 0.0028856719 8.147317e-02 1.618638e-01 15 34893663 34893773 111 - 1.873 1.787 -0.290
ENSG00000021776 E025 61.8166897 0.0036142541 2.704504e-02 6.608883e-02 15 34896897 34896966 70 - 1.760 1.630 -0.441
ENSG00000021776 E026 68.3415383 0.0003507078 4.885947e-02 1.071292e-01 15 34897559 34897705 147 - 1.794 1.697 -0.326
ENSG00000021776 E027 79.7282474 0.0021649801 5.662846e-01 6.932844e-01 15 34900622 34900863 242 - 1.830 1.867 0.123
ENSG00000021776 E028 82.7012378 0.0060587468 4.705560e-01 6.097874e-01 15 34904336 34904505 170 - 1.862 1.824 -0.127
ENSG00000021776 E029 0.1515154 0.0436599945 1.000000e+00   15 34906519 34906544 26 - 0.066 0.000 -9.521
ENSG00000021776 E030 89.6295782 0.0003538997 1.633878e-02 4.347279e-02 15 34906545 34906712 168 - 1.910 1.806 -0.352
ENSG00000021776 E031 87.5099737 0.0020312280 6.105437e-03 1.888635e-02 15 34910135 34910313 179 - 1.906 1.769 -0.460
ENSG00000021776 E032 69.7035795 0.0073673954 1.441915e-01 2.537049e-01 15 34915038 34915179 142 - 1.799 1.705 -0.317
ENSG00000021776 E033 56.3957189 0.0668962768 2.488867e-01 3.846222e-01 15 34918258 34918378 121 - 1.716 1.582 -0.454
ENSG00000021776 E034 56.9090039 0.0006676395 6.332760e-02 1.322416e-01 15 34920332 34920434 103 - 1.713 1.611 -0.346
ENSG00000021776 E035 63.5895979 0.0031902586 8.577656e-02 1.686343e-01 15 34927035 34927138 104 - 1.761 1.663 -0.333
ENSG00000021776 E036 61.5495646 0.0133215767 1.097477e-01 2.051908e-01 15 34930258 34930371 114 - 1.753 1.626 -0.431
ENSG00000021776 E037 58.7666281 0.0004427883 2.222752e-03 7.913807e-03 15 34932318 34932434 117 - 1.741 1.568 -0.588
ENSG00000021776 E038 40.5959126 0.0055455255 1.862786e-02 4.851448e-02 15 34934571 34934635 65 - 1.586 1.406 -0.621
ENSG00000021776 E039 49.7580182 0.0039727737 8.187385e-03 2.425868e-02 15 34938737 34938813 77 - 1.674 1.494 -0.615
ENSG00000021776 E040 54.7887548 0.0026615265 2.166183e-04 1.035213e-03 15 34940899 34940999 101 - 1.725 1.484 -0.821
ENSG00000021776 E041 43.0381425 0.0014238944 2.289558e-02 5.752423e-02 15 34942012 34942080 69 - 1.607 1.457 -0.514
ENSG00000021776 E042 26.4016507 0.0015476453 1.495458e-01 2.610487e-01 15 34944288 34944303 16 - 1.394 1.278 -0.401
ENSG00000021776 E043 57.3903994 0.0004304026 3.075124e-08 3.452899e-07 15 34944304 34944428 125 - 1.758 1.405 -1.204
ENSG00000021776 E044 0.0000000       15 34948134 34948263 130 -      
ENSG00000021776 E045 47.4936141 0.0599344105 1.915255e-03 6.962948e-03 15 34948264 34948384 121 - 1.684 1.271 -1.422
ENSG00000021776 E046 23.2054144 0.0008605798 4.372314e-03 1.418359e-02 15 34952885 34952920 36 - 1.364 1.099 -0.934
ENSG00000021776 E047 22.2272883 0.0009475971 3.222241e-05 1.901990e-04 15 34960774 34960814 41 - 1.370 0.940 -1.541
ENSG00000021776 E048 25.1419787 0.0090326149 2.149931e-04 1.028452e-03 15 34964234 34964290 57 - 1.418 1.026 -1.390
ENSG00000021776 E049 0.1482932 0.0415283770 1.126009e-01   15 34964291 34964453 163 - 0.000 0.215 12.539
ENSG00000021776 E050 37.7984293 0.0221997207 4.461564e-05 2.544163e-04 15 34969539 34969742 204 - 1.594 1.141 -1.575