ENSG00000021762

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263650 ENSG00000021762 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL5 protein_coding protein_coding 5.662278 6.973835 5.23718 0.9872574 0.4114069 -0.4124772 2.50808228 4.0688743 1.6771900 0.5047252 0.22831468 -1.2735486 0.441354167 0.58676667 0.32010000 -0.26666667 3.781107e-05 3.781107e-05 FALSE TRUE
ENST00000348039 ENSG00000021762 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL5 protein_coding protein_coding 5.662278 6.973835 5.23718 0.9872574 0.4114069 -0.4124772 0.72238080 0.7013485 0.9098148 0.3569414 0.03562114 0.3707868 0.132737500 0.08880000 0.17513333 0.08633333 5.788993e-01 3.781107e-05 FALSE TRUE
ENST00000471998 ENSG00000021762 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL5 protein_coding nonsense_mediated_decay 5.662278 6.973835 5.23718 0.9872574 0.4114069 -0.4124772 0.04084195 0.0000000 0.3267356 0.0000000 0.32673562 5.0735444 0.006758333 0.00000000 0.05406667 0.05406667 7.781225e-01 3.781107e-05 FALSE TRUE
ENST00000498536 ENSG00000021762 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL5 protein_coding retained_intron 5.662278 6.973835 5.23718 0.9872574 0.4114069 -0.4124772 0.38771217 0.3032084 0.2583467 0.3032084 0.25834666 -0.2230252 0.057150000 0.03543333 0.05186667 0.01643333 1.000000e+00 3.781107e-05 FALSE FALSE
ENST00000532951 ENSG00000021762 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL5 protein_coding retained_intron 5.662278 6.973835 5.23718 0.9872574 0.4114069 -0.4124772 0.41951781 0.3529715 0.6459484 0.0609015 0.18429358 0.8537260 0.072054167 0.05163333 0.12280000 0.07116667 2.019405e-01 3.781107e-05   FALSE
ENST00000534491 ENSG00000021762 HEK293_OSMI2_2hA HEK293_TMG_2hB OSBPL5 protein_coding retained_intron 5.662278 6.973835 5.23718 0.9872574 0.4114069 -0.4124772 0.95769680 0.6435394 1.1605110 0.1532217 0.06694620 0.8407923 0.179637500 0.09130000 0.22326667 0.13196667 1.124974e-03 3.781107e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000021762 E001 0.7708142 0.0155881947 4.368888e-02 0.0978174673 11 3087107 3087115 9 - 0.440 0.094 -2.861
ENSG00000021762 E002 0.7708142 0.0155881947 4.368888e-02 0.0978174673 11 3087116 3087120 5 - 0.440 0.094 -2.861
ENSG00000021762 E003 10.3785256 0.0016842598 8.691227e-01 0.9198885259 11 3087121 3087378 258 - 1.009 1.028 0.069
ENSG00000021762 E004 32.2225569 0.0009683370 4.424007e-05 0.0002525203 11 3087379 3087579 201 - 1.268 1.559 1.007
ENSG00000021762 E005 54.1092426 0.0054415902 1.395657e-04 0.0007016322 11 3087580 3087783 204 - 1.524 1.771 0.839
ENSG00000021762 E006 36.3474816 0.0223634916 2.484669e-02 0.0615576861 11 3087784 3087905 122 - 1.368 1.596 0.781
ENSG00000021762 E007 14.4790711 0.0103661072 2.688959e-02 0.0657643537 11 3087906 3087915 10 - 0.970 1.217 0.895
ENSG00000021762 E008 28.4421800 0.0022194586 9.704442e-02 0.1859602515 11 3087916 3088000 85 - 1.343 1.467 0.426
ENSG00000021762 E009 42.2882910 0.0018854948 2.054165e-01 0.3329357926 11 3088001 3088177 177 - 1.541 1.620 0.268
ENSG00000021762 E010 39.8502763 0.0009783323 3.222397e-01 0.4655446863 11 3088178 3088343 166 - 1.530 1.590 0.206
ENSG00000021762 E011 34.4782853 0.0006161134 2.622005e-01 0.3999573145 11 3089846 3089948 103 - 1.457 1.530 0.250
ENSG00000021762 E012 36.9455751 0.0043120525 2.859881e-01 0.4263557500 11 3090558 3090696 139 - 1.489 1.564 0.257
ENSG00000021762 E013 0.0000000       11 3090697 3090722 26 -      
ENSG00000021762 E014 40.7256461 0.0005187922 5.418207e-03 0.0170650549 11 3092432 3092558 127 - 1.457 1.627 0.580
ENSG00000021762 E015 54.4415687 0.0072603669 5.933047e-01 0.7157345571 11 3092867 3093052 186 - 1.684 1.718 0.115
ENSG00000021762 E016 9.9794956 0.0023316264 1.624692e-02 0.0432688465 11 3093385 3093526 142 - 1.164 0.916 -0.908
ENSG00000021762 E017 61.4789593 0.0004433894 5.030177e-01 0.6390002144 11 3093527 3093663 137 - 1.773 1.743 -0.101
ENSG00000021762 E018 53.1515006 0.0010387082 2.978694e-01 0.4392432949 11 3093746 3093835 90 - 1.729 1.678 -0.173
ENSG00000021762 E019 49.2935026 0.0008145265 8.266062e-02 0.1637147422 11 3094237 3094334 98 - 1.722 1.634 -0.299
ENSG00000021762 E020 2.2089828 0.0067381417 8.236747e-01 0.8889194298 11 3094335 3094879 545 - 0.504 0.467 -0.182
ENSG00000021762 E021 39.0298731 0.0005801404 8.768636e-01 0.9249655216 11 3100158 3100256 99 - 1.552 1.563 0.036
ENSG00000021762 E022 34.4925295 0.0006363872 4.098704e-01 0.5534951416 11 3101603 3101699 97 - 1.470 1.524 0.184
ENSG00000021762 E023 34.0193310 0.0006382370 3.016513e-01 0.4434633385 11 3102183 3102281 99 - 1.547 1.484 -0.215
ENSG00000021762 E024 31.1307998 0.0006254105 1.824533e-01 0.3042981250 11 3103239 3103320 82 - 1.524 1.440 -0.289
ENSG00000021762 E025 34.5233589 0.0006411323 5.553520e-01 0.6842375419 11 3104193 3104251 59 - 1.536 1.501 -0.120
ENSG00000021762 E026 41.2276175 0.0005837213 1.086271e-01 0.2035074233 11 3104252 3104377 126 - 1.648 1.560 -0.300
ENSG00000021762 E027 56.5398996 0.0012619393 2.080158e-01 0.3361107289 11 3107263 3107455 193 - 1.760 1.700 -0.204
ENSG00000021762 E028 25.3595796 0.0008343483 7.912242e-01 0.8664854323 11 3107771 3107789 19 - 1.392 1.375 -0.060
ENSG00000021762 E029 41.7401712 0.0012342790 2.486956e-01 0.3843865572 11 3107790 3107945 156 - 1.630 1.566 -0.218
ENSG00000021762 E030 29.5994854 0.0009713383 9.269173e-03 0.0269571692 11 3119547 3119631 85 - 1.552 1.384 -0.578
ENSG00000021762 E031 6.2544734 0.0103837578 1.895327e-03 0.0068997694 11 3119632 3119987 356 - 1.062 0.665 -1.540
ENSG00000021762 E032 23.9918572 0.0099523666 3.085150e-01 0.4508044545 11 3120421 3120543 123 - 1.408 1.328 -0.278
ENSG00000021762 E033 18.0920360 0.0012265869 1.579976e-01 0.2724673859 11 3120544 3120607 64 - 1.151 1.276 0.443
ENSG00000021762 E034 13.8849106 0.0015947300 5.330639e-01 0.6653096710 11 3120608 3120624 17 - 1.094 1.155 0.220
ENSG00000021762 E035 0.1515154 0.0426061667 2.713907e-01   11 3121804 3121805 2 - 0.158 0.000 -12.082
ENSG00000021762 E036 0.1515154 0.0426061667 2.713907e-01   11 3121806 3121996 191 - 0.158 0.000 -12.082
ENSG00000021762 E037 16.5934790 0.0014918087 8.949691e-01 0.9368757551 11 3121997 3122025 29 - 1.214 1.204 -0.035
ENSG00000021762 E038 19.9752532 0.0009711103 7.193016e-01 0.8141861691 11 3122026 3122066 41 - 1.298 1.270 -0.096
ENSG00000021762 E039 20.4096159 0.0010542433 1.156337e-01 0.2137419738 11 3122067 3122098 32 - 1.369 1.247 -0.424
ENSG00000021762 E040 0.4449813 0.0232566305 2.774431e-01 0.4170108419 11 3122099 3122347 249 - 0.274 0.094 -1.863
ENSG00000021762 E041 16.0604764 0.0065667505 8.415727e-02 0.1660609053 11 3122348 3122353 6 - 1.298 1.141 -0.556
ENSG00000021762 E042 18.1234590 0.0279470095 4.856757e-02 0.1066236296 11 3122354 3122378 25 - 1.377 1.168 -0.735
ENSG00000021762 E043 22.9984214 0.0210836675 1.394584e-01 0.2472886585 11 3122379 3122428 50 - 1.436 1.296 -0.487
ENSG00000021762 E044 23.0892631 0.0038795355 6.895369e-01 0.7914037736 11 3126473 3126482 10 - 1.369 1.338 -0.106
ENSG00000021762 E045 31.8698148 0.0044168922 2.689031e-01 0.4073670691 11 3126483 3126555 73 - 1.536 1.459 -0.263
ENSG00000021762 E046 0.0000000       11 3126556 3126644 89 -      
ENSG00000021762 E047 39.5137566 0.0250197052 7.501569e-01 0.8369157060 11 3129013 3129169 157 - 1.602 1.559 -0.149
ENSG00000021762 E048 0.0000000       11 3129170 3129329 160 -      
ENSG00000021762 E049 0.3634088 0.3507953739 5.168466e-01   11 3146180 3146661 482 - 0.000 0.172 11.094
ENSG00000021762 E050 1.2545027 0.0289673115 6.910669e-01 0.7926209890 11 3160918 3161393 476 - 0.365 0.295 -0.440
ENSG00000021762 E051 0.0000000       11 3163940 3164423 484 -      
ENSG00000021762 E052 14.1299454 0.0398204488 1.594969e-01 0.2744508682 11 3165216 3165222 7 - 1.009 1.191 0.657
ENSG00000021762 E053 19.0189151 0.0396318374 3.165282e-01 0.4593072767 11 3165223 3165352 130 - 1.177 1.297 0.424
ENSG00000021762 E054 0.1817044 0.0392621466 8.613639e-01   11 3165511 3165770 260 - 0.000 0.094 10.085
ENSG00000021762 E055 0.0000000       11 3166625 3166739 115 -