ENSG00000021645

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000557594 ENSG00000021645 HEK293_OSMI2_2hA HEK293_TMG_2hB NRXN3 protein_coding protein_coding 2.779614 1.600927 4.304062 0.1162242 0.1418052 1.421156 1.1986878 1.0600365 1.4498345 0.07439395 0.08375687 0.4481448 0.4962375 0.66286667 0.33756667 -0.32530000 1.013807e-05 1.013807e-05 FALSE TRUE
ENST00000679122 ENSG00000021645 HEK293_OSMI2_2hA HEK293_TMG_2hB NRXN3 protein_coding protein_coding 2.779614 1.600927 4.304062 0.1162242 0.1418052 1.421156 0.1552770 0.3867859 0.2127807 0.14606282 0.06158098 -0.8327363 0.0792250 0.24696667 0.04866667 -0.19830000 4.988567e-02 1.013807e-05 FALSE TRUE
MSTRG.9994.15 ENSG00000021645 HEK293_OSMI2_2hA HEK293_TMG_2hB NRXN3 protein_coding   2.779614 1.600927 4.304062 0.1162242 0.1418052 1.421156 1.1358196 0.1179248 2.1644865 0.11792482 0.29241353 4.0873067 0.3253250 0.06786667 0.50200000 0.43413333 3.191049e-02 1.013807e-05 FALSE TRUE
MSTRG.9994.17 ENSG00000021645 HEK293_OSMI2_2hA HEK293_TMG_2hB NRXN3 protein_coding   2.779614 1.600927 4.304062 0.1162242 0.1418052 1.421156 0.2193973 0.0000000 0.3640278 0.00000000 0.18518223 5.2250737 0.0667000 0.00000000 0.08583333 0.08583333 3.552745e-01 1.013807e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000021645 E001 0.0000000       14 78170373 78170674 302 +      
ENSG00000021645 E002 0.0000000       14 78242391 78243601 1211 +      
ENSG00000021645 E003 0.0000000       14 78243602 78243802 201 +      
ENSG00000021645 E004 0.0000000       14 78278645 78278662 18 +      
ENSG00000021645 E005 0.0000000       14 78297831 78297860 30 +      
ENSG00000021645 E006 0.0000000       14 78300680 78300691 12 +      
ENSG00000021645 E007 0.0000000       14 78403731 78403749 19 +      
ENSG00000021645 E008 0.0000000       14 78403750 78403878 129 +      
ENSG00000021645 E009 0.0000000       14 78602420 78602489 70 +      
ENSG00000021645 E010 0.0000000       14 78614932 78615032 101 +      
ENSG00000021645 E011 0.0000000       14 78645120 78645421 302 +      
ENSG00000021645 E012 0.0000000       14 78645422 78645427 6 +      
ENSG00000021645 E013 0.0000000       14 78649268 78649291 24 +      
ENSG00000021645 E014 0.0000000       14 78651165 78651326 162 +      
ENSG00000021645 E015 0.0000000       14 78698220 78698289 70 +      
ENSG00000021645 E016 0.0000000       14 78708497 78708552 56 +      
ENSG00000021645 E017 0.0000000       14 78709217 78709655 439 +      
ENSG00000021645 E018 0.0000000       14 78714756 78715139 384 +      
ENSG00000021645 E019 0.0000000       14 78803620 78803823 204 +      
ENSG00000021645 E020 0.0000000       14 78810318 78810344 27 +      
ENSG00000021645 E021 0.0000000       14 78957242 78957361 120 +      
ENSG00000021645 E022 0.0000000       14 78966025 78966406 382 +      
ENSG00000021645 E023 0.0000000       14 78967208 78967398 191 +      
ENSG00000021645 E024 0.0000000       14 78968173 78968346 174 +      
ENSG00000021645 E025 0.0000000       14 78972883 78972909 27 +      
ENSG00000021645 E026 0.0000000       14 78988022 78988141 120 +      
ENSG00000021645 E027 0.0000000       14 78988142 78988299 158 +      
ENSG00000021645 E028 4.6981770 0.0045494615 2.307690e-03 8.176112e-03 14 79279339 79279412 74 + 0.910 0.467 -1.885
ENSG00000021645 E029 16.1848439 0.0011364396 1.372251e-04 6.912961e-04 14 79279413 79279680 268 + 1.355 1.028 -1.166
ENSG00000021645 E030 22.1949939 0.0008952808 4.772081e-05 2.702225e-04 14 79279681 79279905 225 + 1.474 1.173 -1.049
ENSG00000021645 E031 16.4364609 0.0011197399 1.333246e-02 3.669559e-02 14 79279906 79280045 140 + 1.317 1.113 -0.721
ENSG00000021645 E032 6.0349387 0.0031382505 8.624971e-01 9.153288e-01 14 79280046 79280055 10 + 0.847 0.832 -0.057
ENSG00000021645 E033 24.0326355 0.0069233925 2.284803e-02 5.742379e-02 14 79280056 79280200 145 + 1.466 1.292 -0.603
ENSG00000021645 E034 20.6331848 0.0010112702 3.419987e-02 8.014533e-02 14 79280201 79280262 62 + 1.391 1.236 -0.539
ENSG00000021645 E035 33.5273752 0.0006616966 1.148778e-02 3.232376e-02 14 79280263 79280501 239 + 1.592 1.448 -0.495
ENSG00000021645 E036 14.8903797 0.0012308984 2.209313e-02 5.586968e-02 14 79280502 79280538 37 + 1.281 1.086 -0.692
ENSG00000021645 E037 0.0000000       14 79280853 79280864 12 +      
ENSG00000021645 E038 0.1515154 0.0424434481 6.525474e-01   14 79281742 79281905 164 + 0.105 0.000 -9.966
ENSG00000021645 E039 0.0000000       14 79298795 79298908 114 +      
ENSG00000021645 E040 0.0000000       14 79314051 79314149 99 +      
ENSG00000021645 E041 28.2524658 0.0007474319 1.539941e-02 4.139761e-02 14 79467221 79467402 182 + 1.527 1.376 -0.518
ENSG00000021645 E042 0.3030308 0.3399875167 3.961439e-01   14 79570523 79570588 66 + 0.191 0.000 -10.190
ENSG00000021645 E043 0.0000000       14 79572844 79573011 168 +      
ENSG00000021645 E044 28.0187108 0.0007517971 6.540649e-03 2.002985e-02 14 79663778 79663949 172 + 1.527 1.355 -0.592
ENSG00000021645 E045 3.4395150 0.0151178405 7.319426e-01 8.235006e-01 14 79692173 79692262 90 + 0.659 0.612 -0.204
ENSG00000021645 E046 38.1227814 0.0006144978 1.792435e-05 1.123818e-04 14 79697630 79697937 308 + 1.685 1.448 -0.811
ENSG00000021645 E047 17.4619361 0.0010565897 3.118920e-04 1.428085e-03 14 79805112 79805190 79 + 1.381 1.086 -1.040
ENSG00000021645 E048 3.7802380 0.0042056866 2.000856e-01 3.263618e-01 14 79805191 79805199 9 + 0.753 0.569 -0.786
ENSG00000021645 E049 0.1515154 0.0424434481 6.525474e-01   14 79853539 79854069 531 + 0.105 0.000 -9.966
ENSG00000021645 E050 0.2966881 0.0271894978 3.024610e-01   14 79854070 79854217 148 + 0.190 0.000 -11.058
ENSG00000021645 E051 28.6281990 0.0008021709 7.919226e-01 8.669070e-01 14 79861039 79861258 220 + 1.474 1.465 -0.030
ENSG00000021645 E052 22.7310591 0.0008831586 1.641857e-02 4.365359e-02 14 79861259 79861341 83 + 1.275 1.454 0.623
ENSG00000021645 E053 48.0969902 0.0019735463 1.587252e-01 2.734359e-01 14 79861342 79861662 321 + 1.641 1.724 0.279
ENSG00000021645 E054 261.2402205 0.0006142319 1.760321e-28 2.595233e-26 14 79861663 79868291 6629 + 2.305 2.516 0.704