ENSG00000021574

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315285 ENSG00000021574 HEK293_OSMI2_2hA HEK293_TMG_2hB SPAST protein_coding protein_coding 7.776698 2.589565 12.00353 0.1295304 0.3316738 2.208318 1.09606284 0.3580107 2.2350475 0.20561194 0.3572804 2.6089264 0.13014167 0.14693333 0.18500000 0.03806667 0.76949057 0.04666308 FALSE TRUE
ENST00000621856 ENSG00000021574 HEK293_OSMI2_2hA HEK293_TMG_2hB SPAST protein_coding protein_coding 7.776698 2.589565 12.00353 0.1295304 0.3316738 2.208318 0.55770875 0.2534145 0.7185670 0.03464399 0.1641407 1.4677266 0.07554583 0.09736667 0.05973333 -0.03763333 0.40773139 0.04666308 FALSE TRUE
ENST00000642999 ENSG00000021574 HEK293_OSMI2_2hA HEK293_TMG_2hB SPAST protein_coding protein_coding 7.776698 2.589565 12.00353 0.1295304 0.3316738 2.208318 3.98794576 0.3467107 7.4228963 0.34671066 0.3486856 4.3810982 0.43621667 0.13106667 0.61826667 0.48720000 0.06591040 0.04666308 FALSE TRUE
ENST00000645671 ENSG00000021574 HEK293_OSMI2_2hA HEK293_TMG_2hB SPAST protein_coding protein_coding 7.776698 2.589565 12.00353 0.1295304 0.3316738 2.208318 0.47273396 0.5219047 0.6748581 0.29576083 0.4705401 0.3646372 0.10420833 0.20613333 0.05800000 -0.14813333 0.73768884 0.04666308 FALSE TRUE
ENST00000645730 ENSG00000021574 HEK293_OSMI2_2hA HEK293_TMG_2hB SPAST protein_coding protein_coding 7.776698 2.589565 12.00353 0.1295304 0.3316738 2.208318 0.09142193 0.7003992 0.0000000 0.36533090 0.0000000 -6.1505580 0.03792083 0.27136667 0.00000000 -0.27136667 0.04666308 0.04666308 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000021574 E001 1.4060076 0.0095129783 7.340680e-01 8.251342e-01 2 32063556 32063610 55 + 0.286 0.281 -0.041
ENSG00000021574 E002 10.9903696 0.0016282301 4.722122e-01 6.112688e-01 2 32063611 32063781 171 + 0.890 1.107 0.801
ENSG00000021574 E003 7.3514287 0.0022114069 7.748677e-01 8.549298e-01 2 32063782 32063827 46 + 0.754 0.917 0.636
ENSG00000021574 E004 9.8874961 0.0018099981 7.682910e-01 8.502969e-01 2 32063828 32063947 120 + 0.877 0.962 0.321
ENSG00000021574 E005 2.5572856 0.1064964322 3.157732e-01 4.585488e-01 2 32063948 32063955 8 + 0.458 0.281 -1.042
ENSG00000021574 E006 3.0314117 0.0717389529 5.653737e-01 6.924870e-01 2 32063956 32063961 6 + 0.492 0.450 -0.210
ENSG00000021574 E007 3.8191778 0.2668515478 7.658016e-01 8.484787e-01 2 32063962 32063967 6 + 0.554 0.573 0.089
ENSG00000021574 E008 3.8191778 0.2668515478 7.658016e-01 8.484787e-01 2 32063968 32063969 2 + 0.554 0.573 0.089
ENSG00000021574 E009 5.1960537 0.3524554280 6.773958e-01 7.821286e-01 2 32063970 32063990 21 + 0.655 0.669 0.058
ENSG00000021574 E010 5.1573320 0.1268221217 4.095287e-01 5.531364e-01 2 32063991 32063997 7 + 0.666 0.572 -0.410
ENSG00000021574 E011 28.7930455 0.0006964100 4.914846e-03 1.569363e-02 2 32063998 32064210 213 + 1.331 1.191 -0.493
ENSG00000021574 E012 22.7117665 0.0012087996 4.068563e-01 5.504882e-01 2 32064211 32064246 36 + 1.209 1.261 0.184
ENSG00000021574 E013 0.0000000       2 32066002 32066116 115 +      
ENSG00000021574 E014 0.0000000       2 32077829 32077943 115 +      
ENSG00000021574 E015 15.7200639 0.0011394957 2.141007e-02 5.445125e-02 2 32087492 32087494 3 + 1.087 0.917 -0.627
ENSG00000021574 E016 19.7747276 0.0010614872 1.465674e-01 2.570210e-01 2 32087495 32087501 7 + 1.163 1.137 -0.092
ENSG00000021574 E017 35.3465649 0.0005827591 9.692194e-03 2.800400e-02 2 32087502 32087578 77 + 1.409 1.321 -0.304
ENSG00000021574 E018 40.0798893 0.0110633728 1.658902e-04 8.174851e-04 2 32089522 32089605 84 + 1.479 1.216 -0.913
ENSG00000021574 E019 20.9462107 0.0078225514 3.019823e-03 1.032497e-02 2 32098796 32098800 5 + 1.209 0.962 -0.895
ENSG00000021574 E020 36.7673383 0.0005657151 4.765057e-04 2.070187e-03 2 32098801 32098862 62 + 1.436 1.261 -0.608
ENSG00000021574 E021 35.4521000 0.0005751932 1.061189e-03 4.170676e-03 2 32098863 32098891 29 + 1.419 1.261 -0.549
ENSG00000021574 E022 72.1996125 0.0043460846 1.793205e-05 1.124259e-04 2 32114638 32114796 159 + 1.721 1.550 -0.579
ENSG00000021574 E023 41.3662834 0.0151111531 4.192645e-03 1.368559e-02 2 32114797 32114825 29 + 1.486 1.321 -0.568
ENSG00000021574 E024 71.3196808 0.0084817136 3.864901e-05 2.235570e-04 2 32115702 32115835 134 + 1.719 1.527 -0.652
ENSG00000021574 E025 47.0296534 0.0019830727 8.105236e-03 2.404837e-02 2 32116119 32116212 94 + 1.529 1.464 -0.223
ENSG00000021574 E026 0.0000000       2 32126498 32126636 139 +      
ENSG00000021574 E027 0.1451727 0.0427723804 1.000000e+00   2 32126637 32126947 311 + 0.048 0.000 -17.519
ENSG00000021574 E028 42.6760437 0.0005568607 1.618565e-02 4.313419e-02 2 32126948 32127022 75 + 1.485 1.436 -0.167
ENSG00000021574 E029 0.1515154 0.0429037296 1.000000e+00   2 32127023 32128407 1385 + 0.048 0.000 -17.520
ENSG00000021574 E030 42.3082653 0.0007452329 3.219414e-02 7.622658e-02 2 32128408 32128479 72 + 1.478 1.451 -0.095
ENSG00000021574 E031 0.1515154 0.0429037296 1.000000e+00   2 32128480 32130604 2125 + 0.048 0.000 -17.520
ENSG00000021574 E032 40.6322823 0.0006269194 2.079850e-01 3.360695e-01 2 32136563 32136638 76 + 1.448 1.491 0.145
ENSG00000021574 E033 44.6822536 0.0005244399 4.955361e-01 6.323187e-01 2 32136877 32136968 92 + 1.481 1.572 0.309
ENSG00000021574 E034 49.5598810 0.0004890015 6.702534e-02 1.384238e-01 2 32137109 32137188 80 + 1.539 1.550 0.036
ENSG00000021574 E035 41.7248950 0.0005005448 2.475770e-01 3.830983e-01 2 32141904 32141946 43 + 1.463 1.515 0.180
ENSG00000021574 E036 44.2997749 0.0094175108 3.130717e-01 4.555997e-01 2 32143336 32143415 80 + 1.487 1.539 0.177
ENSG00000021574 E037 44.6193282 0.0009641826 2.198239e-01 3.501932e-01 2 32144937 32145007 71 + 1.490 1.539 0.167
ENSG00000021574 E038 0.1451727 0.0427723804 1.000000e+00   2 32147195 32147217 23 + 0.048 0.000 -17.519
ENSG00000021574 E039 43.0084991 0.0041155124 2.089849e-01 3.373054e-01 2 32147218 32147258 41 + 1.477 1.515 0.132
ENSG00000021574 E040 555.6422381 0.0123690920 4.601543e-12 1.011661e-10 2 32154374 32157637 3264 + 2.506 2.885 1.262