ENSG00000020181

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315215 ENSG00000020181 HEK293_OSMI2_2hA HEK293_TMG_2hB ADGRA2 protein_coding protein_coding 2.459628 3.41015 2.282313 0.2150283 0.01093392 -0.5772556 0.09045185 0.3901853 0.03147731 0.04580639 0.03147731 -3.2702739 0.0305625 0.1158 0.01393333 -0.1018667 0.01307317 0.01246336 FALSE TRUE
ENST00000412232 ENSG00000020181 HEK293_OSMI2_2hA HEK293_TMG_2hB ADGRA2 protein_coding protein_coding 2.459628 3.41015 2.282313 0.2150283 0.01093392 -0.5772556 2.36917566 3.0199645 2.25083549 0.22961635 0.04198690 -0.4224449 0.9694375 0.8842 0.98606667 0.1018667 0.01246336 0.01246336 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000020181 E001 0.0000000       8 37784191 37784330 140 +      
ENSG00000020181 E002 0.8815316 0.0131642299 0.0015351103 0.0057503124 8 37796883 37796905 23 + 0.528 0.000 -12.392
ENSG00000020181 E003 17.2410373 0.0011450990 0.0039290074 0.0129432375 8 37796906 37797534 629 + 1.357 1.150 -0.726
ENSG00000020181 E004 14.8504875 0.0023638131 0.0162797325 0.0433422312 8 37814896 37814967 72 + 1.283 1.098 -0.656
ENSG00000020181 E005 20.7449452 0.0009513176 0.0182282820 0.0476309752 8 37828888 37828959 72 + 1.407 1.259 -0.515
ENSG00000020181 E006 20.8556705 0.0009215811 0.1726557684 0.2916654839 8 37829261 37829332 72 + 1.364 1.290 -0.259
ENSG00000020181 E007 16.8375294 0.0010640873 0.7102121356 0.8074339186 8 37829488 37829559 72 + 1.236 1.232 -0.011
ENSG00000020181 E008 24.5997659 0.0007838203 0.3702625106 0.5146981439 8 37829851 37830014 164 + 1.325 1.418 0.322
ENSG00000020181 E009 37.3443614 0.0006123503 0.5694151673 0.6959657495 8 37830710 37830923 214 + 1.568 1.564 -0.013
ENSG00000020181 E010 24.9399987 0.0010885654 0.6381448767 0.7518516250 8 37831423 37831587 165 + 1.400 1.395 -0.016
ENSG00000020181 E011 24.6389638 0.0024386927 0.0435627392 0.0975788670 8 37833010 37833208 199 + 1.457 1.341 -0.402
ENSG00000020181 E012 30.9853538 0.0057019058 0.0028261688 0.0097526221 8 37833688 37833837 150 + 1.590 1.410 -0.618
ENSG00000020181 E013 34.1434601 0.0014635238 0.6828955898 0.7862248984 8 37833967 37834128 162 + 1.524 1.528 0.013
ENSG00000020181 E014 31.6934848 0.0007046182 0.5812037013 0.7057791055 8 37835174 37835398 225 + 1.497 1.492 -0.020
ENSG00000020181 E015 32.1967927 0.0100277964 0.2965253733 0.4377554403 8 37835554 37835770 217 + 1.529 1.480 -0.168
ENSG00000020181 E016 29.7504665 0.0047388205 0.7084325596 0.8060800615 8 37837731 37837939 209 + 1.463 1.466 0.010
ENSG00000020181 E017 20.6025141 0.0044294567 0.2694140478 0.4079225959 8 37838956 37839083 128 + 1.226 1.347 0.427
ENSG00000020181 E018 22.4566209 0.0011190775 0.3283343545 0.4718238867 8 37839499 37839622 124 + 1.274 1.377 0.359
ENSG00000020181 E019 28.5699154 0.0007398895 0.1323847140 0.2374045241 8 37840121 37840266 146 + 1.492 1.423 -0.238
ENSG00000020181 E020 22.0899355 0.0008966130 0.6179083692 0.7356536485 8 37840760 37840849 90 + 1.349 1.341 -0.030
ENSG00000020181 E021 352.1050401 0.0050481274 0.0001330728 0.0006724706 8 37841086 37844896 3811 + 2.442 2.572 0.432