ENSG00000020129

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356090 ENSG00000020129 HEK293_OSMI2_2hA HEK293_TMG_2hB NCDN protein_coding protein_coding 52.71903 88.88379 36.61596 7.214034 0.532683 -1.279216 29.409777 54.682484 16.295595 3.2303978 0.5441020 -1.7459755 0.53580000 0.61763333 0.44553333 -0.17210000 0.0000248182 2.48182e-05 FALSE TRUE
ENST00000373243 ENSG00000020129 HEK293_OSMI2_2hA HEK293_TMG_2hB NCDN protein_coding protein_coding 52.71903 88.88379 36.61596 7.214034 0.532683 -1.279216 13.402555 20.430796 11.690252 2.5865645 0.3834968 -0.8049118 0.25895417 0.22803333 0.31923333 0.09120000 0.0014774830 2.48182e-05 FALSE TRUE
ENST00000437806 ENSG00000020129 HEK293_OSMI2_2hA HEK293_TMG_2hB NCDN protein_coding protein_coding 52.71903 88.88379 36.61596 7.214034 0.532683 -1.279216 2.463608 3.143104 2.584866 0.7752416 0.2856293 -0.2811130 0.05331667 0.03436667 0.07050000 0.03613333 0.0569918292 2.48182e-05 FALSE TRUE
ENST00000459931 ENSG00000020129 HEK293_OSMI2_2hA HEK293_TMG_2hB NCDN protein_coding processed_transcript 52.71903 88.88379 36.61596 7.214034 0.532683 -1.279216 3.829543 4.785570 3.333422 0.3663701 0.2235303 -0.5203765 0.08002917 0.05390000 0.09093333 0.03703333 0.0002226703 2.48182e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000020129 E001 18.98440 1.002895e-03 2.382188e-01 3.720729e-01 1 35557473 35557722 250 + 1.292 1.209 -0.293
ENSG00000020129 E002 12.96949 3.951611e-03 3.361565e-01 4.799663e-01 1 35557723 35557791 69 + 1.138 1.056 -0.296
ENSG00000020129 E003 13.56319 1.312493e-03 2.078565e-01 3.359105e-01 1 35557792 35557798 7 + 1.170 1.064 -0.385
ENSG00000020129 E004 30.37911 4.763752e-03 9.647295e-01 9.817688e-01 1 35557799 35557807 9 + 1.405 1.423 0.060
ENSG00000020129 E005 113.52741 4.803784e-03 3.727902e-01 5.172108e-01 1 35557808 35557830 23 + 1.997 1.977 -0.064
ENSG00000020129 E006 235.60152 5.352539e-03 1.693737e-02 4.479282e-02 1 35557831 35557883 53 + 2.355 2.281 -0.248
ENSG00000020129 E007 196.66340 2.116736e-03 6.138251e-09 7.882284e-08 1 35557884 35558155 272 + 2.348 2.170 -0.595
ENSG00000020129 E008 382.94621 9.895800e-04 2.532623e-06 1.927054e-05 1 35558156 35558223 68 + 2.578 2.485 -0.309
ENSG00000020129 E009 78.56692 6.119576e-03 1.788981e-02 4.690179e-02 1 35558224 35558484 261 + 1.913 1.798 -0.385
ENSG00000020129 E010 33.66924 2.856215e-02 4.561453e-02 1.013242e-01 1 35558506 35558685 180 + 1.594 1.417 -0.608
ENSG00000020129 E011 565.04782 1.085668e-03 5.699768e-04 2.421411e-03 1 35559107 35559247 141 + 2.718 2.665 -0.177
ENSG00000020129 E012 1215.19160 1.228880e-03 4.986845e-03 1.589299e-02 1 35560326 35560934 609 + 3.032 3.006 -0.086
ENSG00000020129 E013 873.92351 3.041363e-04 5.068222e-01 6.424738e-01 1 35560935 35561294 360 + 2.857 2.869 0.039
ENSG00000020129 E014 464.53442 1.935860e-04 6.706929e-01 7.770634e-01 1 35562392 35562467 76 + 2.570 2.599 0.095
ENSG00000020129 E015 633.63464 1.080135e-04 1.127217e-01 2.095148e-01 1 35562468 35562633 166 + 2.691 2.737 0.154
ENSG00000020129 E016 10.83173 2.976718e-02 1.143331e-02 3.219344e-02 1 35562792 35562880 89 + 1.214 0.907 -1.120
ENSG00000020129 E017 807.52824 9.904119e-05 8.650539e-01 9.170473e-01 1 35563202 35563426 225 + 2.815 2.837 0.075
ENSG00000020129 E018 667.41238 1.118783e-04 4.624117e-01 6.022762e-01 1 35563767 35563909 143 + 2.742 2.751 0.028
ENSG00000020129 E019 2594.66092 2.719328e-03 2.805869e-07 2.612234e-06 1 35565227 35566822 1596 + 3.241 3.371 0.432
ENSG00000020129 E020 26.48454 1.670381e-02 9.210629e-01 9.541789e-01 1 35566823 35567274 452 + 1.347 1.379 0.111