ENSG00000019144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356063 ENSG00000019144 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLDB1 protein_coding protein_coding 6.304065 10.1132 4.217866 0.5377737 0.3526619 -1.259664 0.6989928 1.09919445 0.3432403 0.25043387 0.19989419 -1.65079037 0.11546667 0.106733333 0.09023333 -0.01650000 0.8013434990 0.0009409782 FALSE TRUE
ENST00000526699 ENSG00000019144 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLDB1 protein_coding retained_intron 6.304065 10.1132 4.217866 0.5377737 0.3526619 -1.259664 0.1052306 0.06751306 0.3898132 0.06751306 0.31142181 2.36681477 0.01957083 0.006033333 0.08203333 0.07600000 0.4413615006 0.0009409782 FALSE FALSE
ENST00000527898 ENSG00000019144 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLDB1 protein_coding processed_transcript 6.304065 10.1132 4.217866 0.5377737 0.3526619 -1.259664 0.3314786 0.12096737 0.1795211 0.12096737 0.17952107 0.53315084 0.06218750 0.010833333 0.04376667 0.03293333 0.9271620478 0.0009409782 FALSE TRUE
ENST00000534140 ENSG00000019144 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLDB1 protein_coding protein_coding 6.304065 10.1132 4.217866 0.5377737 0.3526619 -1.259664 0.8873514 1.52844442 0.1934969 0.25854411 0.12754132 -2.91839390 0.13999167 0.149733333 0.05130000 -0.09843333 0.2912721368 0.0009409782 FALSE TRUE
MSTRG.6399.12 ENSG00000019144 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLDB1 protein_coding   6.304065 10.1132 4.217866 0.5377737 0.3526619 -1.259664 0.6604147 0.87990954 0.9250232 0.08118173 0.09892043 0.07134353 0.11140833 0.086766667 0.22290000 0.13613333 0.0009409782 0.0009409782 FALSE TRUE
MSTRG.6399.14 ENSG00000019144 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLDB1 protein_coding   6.304065 10.1132 4.217866 0.5377737 0.3526619 -1.259664 0.4035950 0.53404972 0.0000000 0.28222641 0.00000000 -5.76566660 0.05696250 0.052033333 0.00000000 -0.05203333 0.3071843393 0.0009409782 FALSE TRUE
MSTRG.6399.22 ENSG00000019144 HEK293_OSMI2_2hA HEK293_TMG_2hB PHLDB1 protein_coding   6.304065 10.1132 4.217866 0.5377737 0.3526619 -1.259664 1.9445717 4.31909007 1.3689839 0.08947167 0.22760899 -1.65045818 0.28218333 0.428966667 0.32050000 -0.10846667 0.1783382209 0.0009409782 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000019144 E001 0.0000000       11 118606440 118606672 233 +      
ENSG00000019144 E002 1.8862704 0.0102389762 0.529735396 0.662464728 11 118607615 118607615 1 + 0.318 0.442 0.708
ENSG00000019144 E003 2.8105746 0.0310335932 0.776814051 0.856288063 11 118607616 118607632 17 + 0.568 0.524 -0.205
ENSG00000019144 E004 3.6501858 0.0334165172 0.605319063 0.725746186 11 118607633 118607642 10 + 0.679 0.595 -0.367
ENSG00000019144 E005 4.3092254 0.0041435530 0.184333144 0.306663983 11 118607643 118607699 57 + 0.806 0.617 -0.783
ENSG00000019144 E006 0.0000000       11 118610427 118610526 100 +      
ENSG00000019144 E007 0.0000000       11 118613153 118613293 141 +      
ENSG00000019144 E008 0.3666179 0.0286536553 0.454245789 0.594905789 11 118613294 118613450 157 + 0.187 0.078 -1.457
ENSG00000019144 E009 0.0000000       11 118613451 118613815 365 +      
ENSG00000019144 E010 6.1560550 0.0026845803 0.771324387 0.852378761 11 118613816 118613896 81 + 0.806 0.771 -0.137
ENSG00000019144 E011 7.5584385 0.0116559734 0.138060473 0.245376224 11 118614559 118614682 124 + 1.008 0.824 -0.694
ENSG00000019144 E012 0.5180316 0.0222418536 0.394946044 0.538783067 11 118614683 118615194 512 + 0.000 0.201 12.426
ENSG00000019144 E013 0.0000000       11 118615585 118615622 38 +      
ENSG00000019144 E014 11.0050052 0.0015873963 0.594086787 0.716368633 11 118616041 118616211 171 + 0.959 1.026 0.248
ENSG00000019144 E015 0.8450104 0.0161114320 0.119038239 0.218570391 11 118621363 118621375 13 + 0.418 0.144 -2.043
ENSG00000019144 E016 2.8743902 0.0060969708 0.423291757 0.566366900 11 118621376 118621415 40 + 0.627 0.499 -0.586
ENSG00000019144 E017 6.2592994 0.0027827138 0.064736442 0.134616753 11 118621416 118621538 123 + 0.959 0.726 -0.907
ENSG00000019144 E018 0.1817044 0.0404892975 1.000000000   11 118624084 118624511 428 + 0.000 0.078 10.842
ENSG00000019144 E019 0.3697384 0.0274424043 0.662576458 0.770848759 11 118624792 118624845 54 + 0.000 0.144 11.856
ENSG00000019144 E020 15.8981265 0.0011482494 0.951313358 0.973544480 11 118624934 118625059 126 + 1.145 1.157 0.043
ENSG00000019144 E021 0.1451727 0.0428779223 0.169060512   11 118626930 118627304 375 + 0.187 0.000 -13.441
ENSG00000019144 E022 5.3995392 0.0032332162 0.543551205 0.674130743 11 118627305 118627307 3 + 0.806 0.726 -0.323
ENSG00000019144 E023 48.7772247 0.0372214982 0.391707281 0.535637604 11 118627308 118627931 624 + 1.685 1.599 -0.290
ENSG00000019144 E024 69.4489553 0.0183342268 0.147377411 0.258130862 11 118627932 118628650 719 + 1.855 1.744 -0.373
ENSG00000019144 E025 0.2955422 0.0293453963 0.453086208   11 118629979 118630082 104 + 0.187 0.078 -1.463
ENSG00000019144 E026 41.2367352 0.0118659303 0.380999850 0.525276384 11 118631207 118631479 273 + 1.594 1.534 -0.208
ENSG00000019144 E027 11.3818677 0.0067499927 0.883971832 0.929802573 11 118631913 118631915 3 + 1.030 1.018 -0.042
ENSG00000019144 E028 16.4453567 0.0013237835 0.875399150 0.923986644 11 118631916 118631975 60 + 1.177 1.168 -0.031
ENSG00000019144 E029 18.7025099 0.0012567209 0.748063929 0.835416988 11 118631976 118632053 78 + 1.192 1.228 0.125
ENSG00000019144 E030 14.7345087 0.0058568315 0.251132199 0.387293062 11 118632159 118632212 54 + 1.030 1.161 0.474
ENSG00000019144 E031 15.5554050 0.0012578500 0.161580080 0.277164342 11 118632213 118632296 84 + 1.030 1.180 0.540
ENSG00000019144 E032 6.0231306 0.0337324774 0.262075127 0.399798258 11 118632297 118634922 2626 + 0.904 0.742 -0.636
ENSG00000019144 E033 0.3299976 0.0274424043 0.662307341   11 118634923 118634941 19 + 0.000 0.144 11.855
ENSG00000019144 E034 5.3006364 0.0177196382 0.792390372 0.867276250 11 118634942 118634977 36 + 0.679 0.729 0.205
ENSG00000019144 E035 10.1998890 0.0113093438 0.243548835 0.378348472 11 118634978 118635023 46 + 1.072 0.939 -0.490
ENSG00000019144 E036 10.3879230 0.0241146671 0.319383203 0.462465336 11 118635024 118635028 5 + 1.072 0.950 -0.447
ENSG00000019144 E037 11.8511854 0.0219333794 0.261386358 0.399031771 11 118635029 118635051 23 + 1.127 0.997 -0.474
ENSG00000019144 E038 9.9743188 0.0017221453 0.069247782 0.142127391 11 118635052 118635163 112 + 1.110 0.917 -0.710
ENSG00000019144 E039 49.3481848 0.0004845075 0.830372740 0.893567271 11 118635393 118635548 156 + 1.629 1.623 -0.019
ENSG00000019144 E040 33.4239841 0.0007966643 0.616789261 0.734755331 11 118638891 118639001 111 + 1.479 1.452 -0.095
ENSG00000019144 E041 34.8923351 0.0013608752 0.184648276 0.307031869 11 118639162 118639251 90 + 1.394 1.495 0.350
ENSG00000019144 E042 0.7416549 0.0898072972 0.336151469 0.479964205 11 118639252 118639355 104 + 0.318 0.145 -1.443
ENSG00000019144 E043 0.5944058 0.2916861740 0.766301951 0.848840734 11 118639407 118641576 2170 + 0.188 0.148 -0.411
ENSG00000019144 E044 0.2214452 0.0376730288 1.000000000   11 118641577 118641784 208 + 0.000 0.078 10.855
ENSG00000019144 E045 0.1515154 0.0441542281 0.168534630   11 118642039 118642253 215 + 0.188 0.000 -13.433
ENSG00000019144 E046 0.2214452 0.0376730288 1.000000000   11 118642254 118642350 97 + 0.000 0.078 10.855
ENSG00000019144 E047 0.3697384 0.0274424043 0.662576458 0.770848759 11 118642351 118642394 44 + 0.000 0.144 11.856
ENSG00000019144 E048 35.7216171 0.0006440714 0.333040619 0.476713785 11 118643800 118643940 141 + 1.430 1.503 0.250
ENSG00000019144 E049 0.1472490 0.0426340497 0.169036293   11 118643941 118643999 59 + 0.187 0.000 -13.443
ENSG00000019144 E050 0.1472490 0.0426340497 0.169036293   11 118644000 118644071 72 + 0.187 0.000 -13.443
ENSG00000019144 E051 18.9354699 0.0009891807 0.830115447 0.893371589 11 118644072 118644088 17 + 1.207 1.233 0.090
ENSG00000019144 E052 32.4774648 0.0006401194 0.581575079 0.706104066 11 118644089 118644174 86 + 1.412 1.457 0.156
ENSG00000019144 E053 0.9503405 0.0739179343 0.724572326 0.818059612 11 118644175 118644368 194 + 0.318 0.250 -0.468
ENSG00000019144 E054 1.1383745 0.0198279719 0.896261219 0.937704717 11 118644369 118644646 278 + 0.318 0.296 -0.141
ENSG00000019144 E055 2.3852999 0.0066689248 0.279055727 0.418749369 11 118644647 118644691 45 + 0.318 0.525 1.124
ENSG00000019144 E056 1.0726966 0.0121989077 0.579130577 0.704097280 11 118644692 118645355 664 + 0.187 0.297 0.862
ENSG00000019144 E057 76.4651210 0.0004875118 0.885113225 0.930559501 11 118645356 118645650 295 + 1.800 1.813 0.044
ENSG00000019144 E058 1.6177992 0.0085311283 0.116175614 0.214520127 11 118645651 118645734 84 + 0.568 0.297 -1.461
ENSG00000019144 E059 40.0352824 0.0100995568 0.814924880 0.882730059 11 118645735 118645765 31 + 1.537 1.530 -0.025
ENSG00000019144 E060 51.9379039 0.0004906901 0.678433048 0.782899868 11 118645766 118645825 60 + 1.656 1.640 -0.055
ENSG00000019144 E061 2.5692736 0.0076644379 0.002960129 0.010144860 11 118646334 118647774 1441 + 0.806 0.338 -2.196
ENSG00000019144 E062 2.5850665 0.0059426743 0.012828661 0.035513800 11 118647775 118647929 155 + 0.768 0.375 -1.823
ENSG00000019144 E063 64.6224142 0.0004445936 0.196035456 0.321260264 11 118647930 118648076 147 + 1.681 1.754 0.247
ENSG00000019144 E064 49.6846763 0.0005798460 0.672309651 0.778303583 11 118650077 118650193 117 + 1.606 1.637 0.105
ENSG00000019144 E065 63.9593073 0.0047962248 0.311150636 0.453595538 11 118650445 118650547 103 + 1.773 1.724 -0.165
ENSG00000019144 E066 9.3705033 0.0706359680 0.052001307 0.112724616 11 118650601 118655604 5004 + 1.177 0.856 -1.183
ENSG00000019144 E067 62.1370028 0.0037447755 0.289914692 0.430673076 11 118655605 118655690 86 + 1.761 1.711 -0.169
ENSG00000019144 E068 0.2934659 0.0294174833 0.453086526   11 118655860 118655892 33 + 0.187 0.078 -1.463
ENSG00000019144 E069 329.3540925 0.0056097972 0.001036701 0.004085197 11 118656683 118658031 1349 + 2.343 2.471 0.428