ENSG00000018510

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264167 ENSG00000018510 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPS protein_coding protein_coding 17.55241 5.109083 30.05778 0.232617 0.968554 2.554261 2.439859 0.4423168 5.664378 0.4423168 1.2440351 3.649057 0.1337792 0.09306667 0.1915000 0.09843333 0.2643311 0.01777229 FALSE TRUE
ENST00000679459 ENSG00000018510 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPS protein_coding protein_coding 17.55241 5.109083 30.05778 0.232617 0.968554 2.554261 9.267407 1.7898898 15.448961 0.5101130 0.6933494 3.102463 0.4777750 0.34540000 0.5135667 0.16816667 0.3541289 0.01777229 FALSE TRUE
ENST00000680155 ENSG00000018510 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPS protein_coding protein_coding 17.55241 5.109083 30.05778 0.232617 0.968554 2.554261 5.039107 2.4345418 8.282882 0.1871753 1.6056472 1.762310 0.3046417 0.47553333 0.2726667 -0.20286667 0.0332530 0.01777229 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000018510 E001 1.0488529 0.1416638497 0.8818117591 0.928272677 2 177392746 177392746 1 + 0.268 0.241 -0.206
ENSG00000018510 E002 1.0488529 0.1416638497 0.8818117591 0.928272677 2 177392747 177392747 1 + 0.268 0.241 -0.206
ENSG00000018510 E003 3.3622129 0.0047958018 0.5226175924 0.656392895 2 177392748 177392759 12 + 0.533 0.675 0.629
ENSG00000018510 E004 3.6567109 0.0064446347 0.6632871140 0.771374969 2 177392760 177392767 8 + 0.568 0.675 0.469
ENSG00000018510 E005 4.5339761 0.0221570806 0.9246360676 0.956541866 2 177392768 177392772 5 + 0.658 0.674 0.072
ENSG00000018510 E006 64.9383138 0.0017592956 0.0004668123 0.002033156 2 177392773 177393028 256 + 1.742 1.557 -0.627
ENSG00000018510 E007 33.3692440 0.0006060459 0.0019663663 0.007120773 2 177393029 177393035 7 + 1.468 1.241 -0.789
ENSG00000018510 E008 34.1849087 0.0006403660 0.0078551910 0.023417980 2 177393036 177393040 5 + 1.474 1.293 -0.627
ENSG00000018510 E009 34.3063489 0.0011438204 0.0042494763 0.013840331 2 177393041 177393042 2 + 1.478 1.277 -0.700
ENSG00000018510 E010 34.4398683 0.0006496590 0.0018831353 0.006862376 2 177393043 177393049 7 + 1.482 1.259 -0.775
ENSG00000018510 E011 0.6256415 0.0172671820 0.6838006193 0.786916394 2 177393050 177393059 10 + 0.154 0.242 0.811
ENSG00000018510 E012 0.0000000       2 177393060 177393061 2 +      
ENSG00000018510 E013 0.0000000       2 177393062 177393111 50 +      
ENSG00000018510 E014 0.0000000       2 177393112 177393124 13 +      
ENSG00000018510 E015 0.1515154 0.0432846664 1.0000000000   2 177393125 177393275 151 + 0.058 0.000 -19.971
ENSG00000018510 E016 0.1515154 0.0432846664 1.0000000000   2 177393276 177393536 261 + 0.058 0.000 -19.971
ENSG00000018510 E017 0.0000000       2 177393537 177395588 2052 +      
ENSG00000018510 E018 0.0000000       2 177395589 177395676 88 +      
ENSG00000018510 E019 0.0000000       2 177395677 177395678 2 +      
ENSG00000018510 E020 79.6111445 0.0024946568 0.0568889732 0.121272030 2 177420269 177420358 90 + 1.812 1.744 -0.230
ENSG00000018510 E021 0.1451727 0.0434256804 1.0000000000   2 177432986 177433124 139 + 0.058 0.000 -19.970
ENSG00000018510 E022 94.9866641 0.0003233780 0.0985073157 0.188217118 2 177434327 177434417 91 + 1.881 1.843 -0.128
ENSG00000018510 E023 129.4187546 0.0002723257 0.0030489495 0.010410091 2 177436764 177436884 121 + 2.022 1.939 -0.278
ENSG00000018510 E024 115.6313765 0.0002485856 0.0223726858 0.056453797 2 177436980 177437054 75 + 1.970 1.912 -0.196
ENSG00000018510 E025 117.7309667 0.0002510420 0.0286726553 0.069354944 2 177440965 177441036 72 + 1.977 1.924 -0.178
ENSG00000018510 E026 0.5932625 0.1931065602 0.5866364705 0.710169269 2 177441037 177441040 4 + 0.195 0.000 -21.971
ENSG00000018510 E027 3.5773179 0.0049435132 0.5199226494 0.653974970 2 177441041 177442119 1079 + 0.600 0.510 -0.412
ENSG00000018510 E028 1.1897592 0.0113904779 0.7196136069 0.814383660 2 177442120 177442235 116 + 0.300 0.242 -0.413
ENSG00000018510 E029 0.5911862 0.0172671820 0.5252744433 0.658665262 2 177442236 177442406 171 + 0.195 0.000 -21.970
ENSG00000018510 E030 151.7765590 0.0003530150 0.0003459926 0.001564000 2 177442407 177442486 80 + 2.094 1.995 -0.333
ENSG00000018510 E031 0.0000000       2 177442487 177442810 324 +      
ENSG00000018510 E032 143.0526652 0.0002787535 0.0008537464 0.003451036 2 177445546 177445626 81 + 2.067 1.975 -0.309
ENSG00000018510 E033 164.6710298 0.0002921505 0.0137553779 0.037667272 2 177461893 177462018 126 + 2.119 2.070 -0.166
ENSG00000018510 E034 0.3697384 0.0274424043 0.0141768306 0.038627327 2 177462019 177462352 334 + 0.000 0.397 25.487
ENSG00000018510 E035 0.1451727 0.0434256804 1.0000000000   2 177464721 177464879 159 + 0.058 0.000 -19.970
ENSG00000018510 E036 121.6227467 0.0014219412 0.5170237201 0.651509520 2 177468416 177468524 109 + 1.978 1.989 0.036
ENSG00000018510 E037 0.0000000       2 177476668 177476687 20 +      
ENSG00000018510 E038 0.0000000       2 177476688 177476747 60 +      
ENSG00000018510 E039 0.0000000       2 177481572 177481631 60 +      
ENSG00000018510 E040 126.0945479 0.0002472908 0.0252486321 0.062383797 2 177482059 177482186 128 + 2.006 1.953 -0.175
ENSG00000018510 E041 84.4799402 0.0004870803 0.5320668210 0.664441696 2 177493148 177493199 52 + 1.824 1.834 0.033
ENSG00000018510 E042 101.0707244 0.0008960977 0.8865148416 0.931421102 2 177497689 177497765 77 + 1.892 1.939 0.157
ENSG00000018510 E043 135.3023554 0.0003682637 0.2840723435 0.424285649 2 177499618 177499730 113 + 2.010 2.091 0.273
ENSG00000018510 E044 0.1472490 0.0448415168 1.0000000000   2 177499731 177499883 153 + 0.058 0.000 -19.970
ENSG00000018510 E045 129.9500661 0.0011791118 0.0641032154 0.133528630 2 177505506 177505575 70 + 1.985 2.099 0.383
ENSG00000018510 E046 120.7688873 0.0036620687 0.1001499115 0.190705508 2 177507970 177508031 62 + 1.953 2.068 0.389
ENSG00000018510 E047 0.0000000       2 177508032 177508229 198 +      
ENSG00000018510 E048 111.5180998 0.0083227601 0.1219835085 0.222760622 2 177513819 177513908 90 + 1.916 2.044 0.431
ENSG00000018510 E049 104.6904416 0.0023727535 0.2388715494 0.372811472 2 177521269 177521328 60 + 1.897 1.992 0.320
ENSG00000018510 E050 99.7665870 0.0003171786 0.0310644752 0.074037234 2 177521329 177521368 40 + 1.868 2.001 0.448
ENSG00000018510 E051 115.4552492 0.0002798268 0.0445060829 0.099292758 2 177523748 177523805 58 + 1.934 2.056 0.408
ENSG00000018510 E052 0.1817044 0.0444769825 0.0830015258   2 177523806 177524950 1145 + 0.000 0.242 24.487
ENSG00000018510 E053 1174.7381908 0.0146358735 0.1454151757 0.255414237 2 177538074 177543834 5761 + 2.940 3.049 0.361
ENSG00000018510 E054 0.5244761 0.2539795916 0.4790735605 0.617487859 2 177551363 177551582 220 + 0.109 0.245 1.416
ENSG00000018510 E055 1.2909221 0.0102626261 0.0366222274 0.084752035 2 177558752 177559299 548 + 0.195 0.600 2.395
ENSG00000018510 E056 2.5819434 0.0064516380 0.0002577748 0.001207613 2 177566821 177567024 204 + 0.267 0.888 2.982