ENSG00000018236

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347616 ENSG00000018236 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTN1 protein_coding protein_coding 2.183906 0.7924177 3.814296 0.1911293 0.2227928 2.252769 0.1272537 0.0000000 0.0000000 0.00000000 0.00000000 0.0000000 0.09555417 0.0000000 0.00000000 0.00000000   0.001469313 FALSE TRUE
ENST00000547702 ENSG00000018236 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTN1 protein_coding protein_coding 2.183906 0.7924177 3.814296 0.1911293 0.2227928 2.252769 0.2242499 0.0000000 0.3641535 0.00000000 0.07900075 5.2255583 0.08146667 0.0000000 0.09433333 0.09433333 0.015617515 0.001469313 FALSE TRUE
ENST00000551295 ENSG00000018236 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTN1 protein_coding protein_coding 2.183906 0.7924177 3.814296 0.1911293 0.2227928 2.252769 1.2837294 0.5703759 2.4479770 0.04032366 0.17815069 2.0824118 0.54605000 0.7812333 0.65046667 -0.13076667 0.692880501 0.001469313 FALSE TRUE
ENST00000551424 ENSG00000018236 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTN1 protein_coding protein_coding 2.183906 0.7924177 3.814296 0.1911293 0.2227928 2.252769 0.1180768 0.1878961 0.1474166 0.18789609 0.14741659 -0.3301555 0.04532917 0.1605000 0.03626667 -0.12423333 0.796985627 0.001469313   FALSE
MSTRG.7118.4 ENSG00000018236 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTN1 protein_coding   2.183906 0.7924177 3.814296 0.1911293 0.2227928 2.252769 0.3032534 0.0000000 0.7722583 0.00000000 0.22586115 6.2895731 0.12785833 0.0000000 0.19790000 0.19790000 0.001469313 0.001469313 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000018236 E001 0.2987644 0.0275219290 1.000000e+00   12 40692439 40692441 3 + 0.108 0.000 -9.126
ENSG00000018236 E002 0.5932625 0.1804131514 6.543174e-01 7.645190e-01 12 40692442 40692461 20 + 0.195 0.000 -11.895
ENSG00000018236 E003 1.7120452 0.1699469278 8.113113e-01 8.802624e-01 12 40692462 40692468 7 + 0.357 0.398 0.236
ENSG00000018236 E004 7.6405275 0.0023271455 6.938784e-01 7.948379e-01 12 40692469 40692592 124 + 0.832 0.889 0.219
ENSG00000018236 E005 0.0000000       12 40742351 40742352 2 +      
ENSG00000018236 E006 0.0000000       12 40742353 40742469 117 +      
ENSG00000018236 E007 0.7696683 0.0160993623 2.003013e-01 3.265928e-01 12 40763096 40763198 103 + 0.153 0.398 1.821
ENSG00000018236 E008 0.1482932 0.0412886918 7.269455e-02   12 40828059 40828183 125 + 0.000 0.242 12.593
ENSG00000018236 E009 0.0000000       12 40828184 40828301 118 +      
ENSG00000018236 E010 3.0377545 0.0955138985 5.266025e-01 6.597991e-01 12 40895950 40896087 138 + 0.550 0.398 -0.762
ENSG00000018236 E011 0.3332198 0.0298131561 2.255040e-01   12 40896088 40896109 22 + 0.057 0.243 2.407
ENSG00000018236 E012 0.0000000       12 40908354 40908356 3 +      
ENSG00000018236 E013 4.8276705 0.0032950989 5.869872e-01 7.104010e-01 12 40908357 40908358 2 + 0.695 0.602 -0.400
ENSG00000018236 E014 14.2042007 0.0012941033 2.290673e-01 3.613145e-01 12 40908359 40908493 135 + 1.054 1.183 0.465
ENSG00000018236 E015 10.0520331 0.0027688824 6.236955e-01 7.402130e-01 12 40910073 40910105 33 + 0.936 1.000 0.237
ENSG00000018236 E016 20.2702057 0.0166684292 8.278073e-01 8.917589e-01 12 40918639 40918771 133 + 1.229 1.204 -0.089
ENSG00000018236 E017 22.0250903 0.0250452935 5.723341e-01 6.984700e-01 12 40922256 40922428 173 + 1.270 1.204 -0.232
ENSG00000018236 E018 14.0729637 0.0026876799 6.390336e-01 7.525236e-01 12 40924557 40924652 96 + 1.085 1.031 -0.196
ENSG00000018236 E019 23.0018074 0.0046137987 1.452530e-03 5.481951e-03 12 40929796 40930002 207 + 1.326 0.966 -1.294
ENSG00000018236 E020 15.8028074 0.0011442340 1.067973e-02 3.040506e-02 12 40933461 40933560 100 + 1.168 0.845 -1.193
ENSG00000018236 E021 19.6777093 0.0093807112 1.579400e-03 5.891983e-03 12 40933697 40933878 182 + 1.261 0.846 -1.520
ENSG00000018236 E022 19.4410594 0.0009297986 2.019258e-03 7.285411e-03 12 40936781 40936905 125 + 1.254 0.889 -1.330
ENSG00000018236 E023 19.3294236 0.0010175482 1.389867e-02 3.799729e-02 12 40937570 40937687 118 + 1.244 0.966 -1.004
ENSG00000018236 E024 21.2655907 0.0009628397 6.167869e-01 7.347553e-01 12 40939335 40939485 151 + 1.251 1.204 -0.166
ENSG00000018236 E025 17.2105091 0.0012031437 9.982277e-01 1.000000e+00 12 40943597 40943724 128 + 1.159 1.161 0.007
ENSG00000018236 E026 17.4776736 0.0012300380 9.376025e-01 9.647762e-01 12 40943995 40944170 176 + 1.167 1.161 -0.023
ENSG00000018236 E027 14.9362575 0.0018562223 6.557034e-01 7.655395e-01 12 40959114 40959234 121 + 1.110 1.060 -0.178
ENSG00000018236 E028 2.8108839 0.0053480148 4.993466e-01 6.356568e-01 12 40971434 40972435 1002 + 0.532 0.398 -0.681
ENSG00000018236 E029 18.5749133 0.0035821097 5.480781e-01 6.779742e-01 12 40980909 40981067 159 + 1.200 1.138 -0.220
ENSG00000018236 E030 17.6099393 0.0010516584 7.455277e-02 1.508228e-01 12 40993120 40993269 150 + 1.200 1.000 -0.723
ENSG00000018236 E031 0.0000000       12 41005039 41005110 72 +      
ENSG00000018236 E032 12.0076642 0.0016414098 3.860479e-01 5.302363e-01 12 41014228 41014298 71 + 1.037 0.929 -0.401
ENSG00000018236 E033 23.9670511 0.0041160363 5.337741e-01 6.659065e-01 12 41016682 41016916 235 + 1.284 1.342 0.201
ENSG00000018236 E034 17.3417786 0.0395602843 9.785432e-01 9.907122e-01 12 41020337 41020440 104 + 1.164 1.175 0.041
ENSG00000018236 E035 17.7625163 0.0013481196 1.601646e-01 2.753396e-01 12 41025150 41025336 187 + 1.142 1.278 0.484
ENSG00000018236 E036 17.3936963 0.0011249372 4.453509e-01 5.868999e-01 12 41027857 41027969 113 + 1.146 1.224 0.276
ENSG00000018236 E037 13.0734388 0.0215283223 7.059702e-01 8.042234e-01 12 41029063 41029113 51 + 1.037 1.088 0.183
ENSG00000018236 E038 17.1596141 0.1056247609 5.375886e-01 6.691275e-01 12 41029114 41029219 106 + 1.129 1.269 0.496
ENSG00000018236 E039 0.5138669 0.0212255658 4.264738e-01 5.692939e-01 12 41061762 41061884 123 + 0.108 0.243 1.409
ENSG00000018236 E040 90.0534914 0.0003226906 1.986743e-09 2.783070e-08 12 41069959 41072415 2457 + 1.799 2.037 0.802