ENSG00000015285

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376701 ENSG00000015285 HEK293_OSMI2_2hA HEK293_TMG_2hB WAS protein_coding protein_coding 0.8723391 0.9123733 0.8155632 0.1960984 0.2306959 -0.1599721 0.22795089 0.23800810 0.17084814 0.23800810 0.09286962 -0.4556085 0.26127083 0.18283333 0.2014667 0.01863333 0.75661844 0.03860254 FALSE TRUE
ENST00000450772 ENSG00000015285 HEK293_OSMI2_2hA HEK293_TMG_2hB WAS protein_coding protein_coding 0.8723391 0.9123733 0.8155632 0.1960984 0.2306959 -0.1599721 0.26025973 0.08419781 0.33578894 0.04252846 0.03328735 1.8761264 0.30368750 0.08986667 0.4601333 0.37026667 0.03860254 0.03860254 FALSE FALSE
ENST00000465982 ENSG00000015285 HEK293_OSMI2_2hA HEK293_TMG_2hB WAS protein_coding processed_transcript 0.8723391 0.9123733 0.8155632 0.1960984 0.2306959 -0.1599721 0.01298721 0.00000000 0.10389771 0.00000000 0.05482690 3.5096668 0.01443750 0.00000000 0.1155000 0.11550000 0.10015286 0.03860254 FALSE FALSE
ENST00000470107 ENSG00000015285 HEK293_OSMI2_2hA HEK293_TMG_2hB WAS protein_coding processed_transcript 0.8723391 0.9123733 0.8155632 0.1960984 0.2306959 -0.1599721 0.03541243 0.00000000 0.12868478 0.00000000 0.12868478 3.7937375 0.03673333 0.00000000 0.1009667 0.10096667 0.72257845 0.03860254   FALSE
MSTRG.34209.2 ENSG00000015285 HEK293_OSMI2_2hA HEK293_TMG_2hB WAS protein_coding   0.8723391 0.9123733 0.8155632 0.1960984 0.2306959 -0.1599721 0.27353830 0.59016742 0.07634367 0.06136414 0.07634367 -2.7972027 0.32288750 0.72733333 0.1219333 -0.60540000 0.13801345 0.03860254 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000015285 E001 1.4070372 0.011884746 0.1359811944 0.242451664 X 48676596 48676620 25 + 0.500 0.240 -1.557
ENSG00000015285 E002 3.2838574 0.004982670 0.6062182108 0.726420519 X 48676621 48676748 128 + 0.650 0.568 -0.362
ENSG00000015285 E003 1.1039192 0.091860952 0.7362543203 0.826794846 X 48683268 48683363 96 + 0.361 0.295 -0.419
ENSG00000015285 E004 1.1855920 0.012198144 0.0610766740 0.128447333 X 48683799 48683818 20 + 0.500 0.173 -2.143
ENSG00000015285 E005 0.7427016 0.015865837 0.0029138524 0.010011255 X 48683819 48683819 1 + 0.500 0.000 -12.731
ENSG00000015285 E006 1.9605709 0.007766342 0.1238202157 0.225406405 X 48683820 48683827 8 + 0.605 0.347 -1.308
ENSG00000015285 E007 5.8731772 0.003130259 0.1329730072 0.238245243 X 48683828 48683985 158 + 0.922 0.733 -0.740
ENSG00000015285 E008 6.1893420 0.003066460 0.7556091441 0.840888927 X 48684283 48684423 141 + 0.849 0.805 -0.170
ENSG00000015285 E009 4.3878638 0.004122631 0.4292819944 0.572026742 X 48685547 48685633 87 + 0.761 0.647 -0.473
ENSG00000015285 E010 3.2558440 0.033888028 0.8079374527 0.877955642 X 48685734 48685778 45 + 0.606 0.571 -0.154
ENSG00000015285 E011 3.9984584 0.005198323 0.1702378790 0.288484341 X 48685779 48685836 58 + 0.792 0.595 -0.823
ENSG00000015285 E012 4.4587531 0.003943320 0.2074179925 0.335407933 X 48685946 48685987 42 + 0.821 0.646 -0.716
ENSG00000015285 E013 3.6000408 0.043950193 0.0863741047 0.169601424 X 48686081 48686134 54 + 0.821 0.535 -1.210
ENSG00000015285 E014 3.2240588 0.094320502 0.1998077573 0.326000568 X 48686781 48686819 39 + 0.760 0.506 -1.107
ENSG00000015285 E015 7.9492053 0.002424977 0.5575818472 0.685971826 X 48686820 48686955 136 + 0.965 0.895 -0.263
ENSG00000015285 E016 5.6076336 0.003220097 0.7060353740 0.804273323 X 48688054 48688096 43 + 0.761 0.805 0.177
ENSG00000015285 E017 0.2998086 0.030491739 0.6821020824   X 48688097 48688198 102 + 0.156 0.095 -0.826
ENSG00000015285 E018 0.0000000       X 48688279 48688299 21 +      
ENSG00000015285 E019 6.3072823 0.032332704 0.3873585469 0.531497897 X 48688300 48688453 154 + 0.761 0.878 0.461
ENSG00000015285 E020 7.4301335 0.004645351 0.0023008070 0.008153099 X 48688660 48689019 360 + 0.556 0.971 1.685
ENSG00000015285 E021 5.8361831 0.063143928 0.0123744566 0.034433531 X 48689020 48689066 47 + 0.436 0.893 1.978
ENSG00000015285 E022 6.3929114 0.044491149 0.0127978296 0.035439323 X 48689320 48689434 115 + 0.500 0.918 1.752
ENSG00000015285 E023 0.1472490 0.042365801 0.2851426188   X 48689435 48689594 160 + 0.156 0.000 -10.408
ENSG00000015285 E024 7.3392629 0.002872662 0.0003554295 0.001601043 X 48691107 48691427 321 + 0.500 0.992 2.026