ENSG00000015171

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381591 ENSG00000015171 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND11 protein_coding protein_coding 10.55419 4.20002 17.61312 0.08138641 0.6175376 2.06557 0.9452070 0.3771233 2.06535436 0.13693889 0.40038415 2.4224927 0.08702917 0.09103333 0.116100000 0.02506667 0.7846593915 0.0001485071 FALSE TRUE
ENST00000381604 ENSG00000015171 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND11 protein_coding protein_coding 10.55419 4.20002 17.61312 0.08138641 0.6175376 2.06557 4.4096280 1.6158945 7.53852873 0.88614568 0.18766859 2.2149618 0.42619167 0.38250000 0.429200000 0.04670000 0.9098286199 0.0001485071 FALSE TRUE
ENST00000381607 ENSG00000015171 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND11 protein_coding protein_coding 10.55419 4.20002 17.61312 0.08138641 0.6175376 2.06557 0.8767189 0.8970703 1.40677034 0.44853513 0.75082507 0.6433197 0.11356250 0.21710000 0.082033333 -0.13506667 0.8424106722 0.0001485071 FALSE TRUE
ENST00000488275 ENSG00000015171 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND11 protein_coding retained_intron 10.55419 4.20002 17.61312 0.08138641 0.6175376 2.06557 0.5582255 0.1224986 0.72679073 0.01853833 0.45961453 2.4752777 0.05230417 0.02903333 0.039633333 0.01060000 0.9797039414 0.0001485071 FALSE FALSE
ENST00000558098 ENSG00000015171 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND11 protein_coding protein_coding 10.55419 4.20002 17.61312 0.08138641 0.6175376 2.06557 1.9286459 0.3175891 3.70779124 0.03109040 0.37387972 3.5044866 0.13348333 0.07540000 0.209800000 0.13440000 0.0001485071 0.0001485071 FALSE TRUE
MSTRG.3460.15 ENSG00000015171 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYND11 protein_coding   10.55419 4.20002 17.61312 0.08138641 0.6175376 2.06557 0.3919967 0.2667164 0.06965028 0.26671639 0.06965028 -1.7966568 0.03721250 0.06326667 0.003733333 -0.05953333 0.8178929400 0.0001485071 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000015171 E001 0.0000000       10 134272 134464 193 +      
ENSG00000015171 E002 0.1515154 0.0424474678 1.000000e+00   10 134465 134483 19 + 0.064 0.000 -8.822
ENSG00000015171 E003 1.0330470 0.0119026251 1.418706e-01 2.505963e-01 10 134484 134702 219 + 0.324 0.000 -13.673
ENSG00000015171 E004 1.3296214 0.0163554307 8.027216e-02 1.599827e-01 10 134703 134786 84 + 0.385 0.000 -13.961
ENSG00000015171 E005 1.0308569 0.0189367685 1.436877e-01 2.530322e-01 10 134787 134892 106 + 0.324 0.000 -13.610
ENSG00000015171 E006 1.1749829 0.2379112273 6.828899e-01 7.862239e-01 10 135059 135068 10 + 0.253 0.376 0.800
ENSG00000015171 E007 3.6182152 0.0043072402 9.313207e-01 9.607484e-01 10 135069 135203 135 + 0.586 0.637 0.226
ENSG00000015171 E008 6.6673969 0.0024462454 3.942084e-01 5.380829e-01 10 135204 135302 99 + 0.837 0.754 -0.329
ENSG00000015171 E009 3.6548501 0.0042227904 2.816599e-01 4.215785e-01 10 135455 135471 17 + 0.637 0.478 -0.734
ENSG00000015171 E010 4.4018181 0.0036109090 1.300217e-01 2.342000e-01 10 135472 135483 12 + 0.710 0.478 -1.042
ENSG00000015171 E011 5.8839990 0.0027454803 7.616106e-02 1.533689e-01 10 135484 135507 24 + 0.816 0.565 -1.056
ENSG00000015171 E012 5.8839990 0.0027454803 7.616106e-02 1.533689e-01 10 135508 135508 1 + 0.816 0.565 -1.056
ENSG00000015171 E013 6.9138237 0.0023636995 7.093188e-02 1.448870e-01 10 135509 135518 10 + 0.875 0.637 -0.963
ENSG00000015171 E014 12.0671832 0.0015060347 3.378474e-01 4.817306e-01 10 135519 135559 41 + 1.053 0.986 -0.248
ENSG00000015171 E015 20.4726628 0.0009099615 1.289556e-01 2.327134e-01 10 179994 180012 19 + 1.273 1.177 -0.341
ENSG00000015171 E016 49.4265284 0.0004809098 3.825320e-04 1.707134e-03 10 180013 180128 116 + 1.656 1.473 -0.624
ENSG00000015171 E017 0.4439371 0.0215568342 5.630689e-01 6.905921e-01 10 197911 198005 95 + 0.169 0.000 -12.439
ENSG00000015171 E018 74.1145317 0.0003964538 8.416657e-05 4.477787e-04 10 209889 210048 160 + 1.825 1.667 -0.536
ENSG00000015171 E019 0.1817044 0.0394957601 1.157866e-01   10 218455 218499 45 + 0.000 0.222 12.554
ENSG00000015171 E020 70.5812337 0.0005388704 2.351254e-04 1.113178e-03 10 221195 221356 162 + 1.804 1.654 -0.507
ENSG00000015171 E021 62.8982352 0.0032892556 1.506133e-03 5.656218e-03 10 236838 236915 78 + 1.757 1.606 -0.510
ENSG00000015171 E022 62.4211017 0.0004166093 3.818153e-01 5.260911e-01 10 237585 237677 93 + 1.723 1.725 0.006
ENSG00000015171 E023 57.1199506 0.0004549516 7.744315e-02 1.553529e-01 10 239438 239525 88 + 1.694 1.641 -0.179
ENSG00000015171 E024 3.2277631 0.0078474826 7.615393e-01 8.453800e-01 10 239962 240055 94 + 0.549 0.637 0.394
ENSG00000015171 E025 38.9567638 0.0006622314 8.402911e-02 1.658478e-01 10 240056 240058 3 + 1.535 1.463 -0.248
ENSG00000015171 E026 51.2364743 0.0005087804 5.791271e-02 1.230528e-01 10 240059 240111 53 + 1.651 1.584 -0.227
ENSG00000015171 E027 53.8529242 0.0005367022 9.940901e-02 1.895824e-01 10 240893 240970 78 + 1.669 1.621 -0.165
ENSG00000015171 E028 58.1742794 0.0004420072 1.897966e-01 3.135040e-01 10 242021 242139 119 + 1.698 1.673 -0.085
ENSG00000015171 E029 0.5932625 0.1610775557 4.312113e-01 5.737823e-01 10 244471 244600 130 + 0.213 0.000 -12.160
ENSG00000015171 E030 101.9465577 0.0003450443 1.242994e-01 2.261288e-01 10 246766 246973 208 + 1.939 1.923 -0.052
ENSG00000015171 E031 0.0000000       10 246974 246999 26 +      
ENSG00000015171 E032 70.9531544 0.0003621401 3.479879e-01 4.921926e-01 10 247398 247466 69 + 1.779 1.781 0.006
ENSG00000015171 E033 151.3861050 0.0002594363 1.195019e-02 3.341345e-02 10 248336 248608 273 + 2.111 2.074 -0.125
ENSG00000015171 E034 105.3692961 0.0002804303 6.768084e-01 7.816678e-01 10 248903 249088 186 + 1.931 1.996 0.218
ENSG00000015171 E035 4.5223547 0.0159051743 1.394510e-03 5.289002e-03 10 249089 249261 173 + 0.508 1.014 2.072
ENSG00000015171 E036 467.9089392 0.0033775348 1.901659e-16 7.897052e-15 10 252348 254637 2290 + 2.523 2.773 0.832