ENSG00000015133

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389857 ENSG00000015133 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88C protein_coding protein_coding 3.707187 4.386156 2.771603 0.1348385 0.1246416 -0.660326 2.2184847 2.09365023 1.7399683 0.28561833 0.04823066 -0.2655661 0.60311667 0.47573333 0.6288000 0.1530667 0.190620614 0.001158061 FALSE TRUE
ENST00000555995 ENSG00000015133 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88C protein_coding retained_intron 3.707187 4.386156 2.771603 0.1348385 0.1246416 -0.660326 0.1535185 0.06136807 0.3556327 0.06136807 0.16523791 2.3570445 0.04639583 0.01333333 0.1235333 0.1102000 0.088886720 0.001158061 FALSE FALSE
ENST00000556726 ENSG00000015133 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC88C protein_coding protein_coding 3.707187 4.386156 2.771603 0.1348385 0.1246416 -0.660326 0.7912547 1.73917053 0.2489792 0.36204481 0.01660653 -2.7557630 0.19582917 0.39760000 0.0906000 -0.3070000 0.001158061 0.001158061 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000015133 E001 217.4594506 0.0164290618 2.106910e-06 1.630772e-05 14 91271323 91273468 2146 - 2.094 2.414 1.068
ENSG00000015133 E002 31.7252209 0.0011278067 9.864137e-03 2.842998e-02 14 91273469 91273653 185 - 1.345 1.568 0.769
ENSG00000015133 E003 29.4997158 0.0024872125 2.446496e-02 6.078045e-02 14 91277922 91278140 219 - 1.321 1.532 0.729
ENSG00000015133 E004 16.2620560 0.0023851155 4.358240e-01 5.779841e-01 14 91278141 91278211 71 - 1.131 1.251 0.426
ENSG00000015133 E005 17.5183959 0.0011884747 7.221250e-01 8.163188e-01 14 91279238 91279306 69 - 1.190 1.270 0.283
ENSG00000015133 E006 0.5848540 0.0283473098 1.897620e-01 3.134639e-01 14 91279307 91279977 671 - 0.000 0.259 12.243
ENSG00000015133 E007 0.6277178 0.0240318969 1.384398e-01 2.459189e-01 14 91281162 91281308 147 - 0.337 0.104 -2.116
ENSG00000015133 E008 16.2916976 0.0301810245 1.479561e-01 2.588946e-01 14 91281457 91281525 69 - 1.278 1.170 -0.382
ENSG00000015133 E009 25.0347865 0.0008349569 1.604188e-01 2.756915e-01 14 91283329 91283517 189 - 1.422 1.376 -0.160
ENSG00000015133 E010 0.8167960 0.0154273264 9.256701e-01 9.572183e-01 14 91283518 91283623 106 - 0.251 0.258 0.053
ENSG00000015133 E011 6.2980211 0.0026897785 9.863497e-01 9.954929e-01 14 91285395 91285836 442 - 0.811 0.859 0.186
ENSG00000015133 E012 2.2069977 0.0121699206 2.536073e-03 8.871456e-03 14 91288732 91289104 373 - 0.724 0.258 -2.403
ENSG00000015133 E013 30.9342609 0.0067161747 5.540077e-01 6.830612e-01 14 91289105 91289343 239 - 1.476 1.487 0.036
ENSG00000015133 E014 19.5641897 0.0010711116 9.922275e-01 9.992426e-01 14 91290995 91291084 90 - 1.260 1.312 0.180
ENSG00000015133 E015 22.5482502 0.0091298712 8.662694e-01 9.178986e-01 14 91294173 91294318 146 - 1.305 1.373 0.239
ENSG00000015133 E016 21.5238946 0.0009003105 6.345050e-01 7.489459e-01 14 91297305 91297491 187 - 1.329 1.345 0.054
ENSG00000015133 E017 17.9993493 0.0010967546 2.121993e-01 3.411189e-01 14 91299927 91300070 144 - 1.287 1.237 -0.178
ENSG00000015133 E018 25.1266792 0.0008250441 2.024366e-02 5.199219e-02 14 91303701 91303978 278 - 1.459 1.350 -0.376
ENSG00000015133 E019 16.6487248 0.0037277156 5.325008e-01 6.648584e-01 14 91305765 91305926 162 - 1.221 1.217 -0.015
ENSG00000015133 E020 20.7026776 0.0080330031 9.648998e-01 9.818925e-01 14 91307038 91307226 189 - 1.279 1.336 0.200
ENSG00000015133 E021 19.2183343 0.0206825491 5.965834e-01 7.185039e-01 14 91308351 91308492 142 - 1.211 1.326 0.403
ENSG00000015133 E022 17.4200416 0.0081219186 7.335696e-01 8.247581e-01 14 91309859 91309986 128 - 1.231 1.252 0.072
ENSG00000015133 E023 59.9500045 0.0016625621 3.317226e-02 7.814844e-02 14 91313080 91313942 863 - 1.795 1.747 -0.164
ENSG00000015133 E024 22.0641954 0.0009002213 4.916164e-03 1.569678e-02 14 91313943 91314150 208 - 1.435 1.282 -0.530
ENSG00000015133 E025 16.5897720 0.0012070045 1.049552e-01 1.980265e-01 14 91315650 91315787 138 - 1.279 1.194 -0.299
ENSG00000015133 E026 0.0000000       14 91315788 91315870 83 -      
ENSG00000015133 E027 18.3893718 0.0241381084 5.406633e-01 6.717644e-01 14 91321120 91321304 185 - 1.270 1.263 -0.024
ENSG00000015133 E028 13.9888273 0.0022134045 1.215237e-01 2.221072e-01 14 91324779 91324923 145 - 1.211 1.120 -0.324
ENSG00000015133 E029 10.9639648 0.0018864321 3.277706e-01 4.712431e-01 14 91325910 91326056 147 - 1.091 1.042 -0.179
ENSG00000015133 E030 5.3874255 0.0030096821 5.708818e-02 1.216174e-01 14 91338005 91338053 49 - 0.905 0.704 -0.794
ENSG00000015133 E031 10.3662970 0.0017748615 3.749504e-01 5.193855e-01 14 91338054 91338163 110 - 1.063 1.020 -0.156
ENSG00000015133 E032 11.7928545 0.0015154121 1.778283e-01 2.984052e-01 14 91338489 91338570 82 - 1.143 1.063 -0.290
ENSG00000015133 E033 0.4418608 0.0258705106 3.225342e-02 7.633884e-02 14 91338571 91338856 286 - 0.337 0.000 -13.386
ENSG00000015133 E034 0.1451727 0.0429177048 3.054360e-01   14 91338862 91339277 416 - 0.143 0.000 -11.753
ENSG00000015133 E035 16.5107316 0.0010901118 4.281172e-02 9.619961e-02 14 91339278 91339462 185 - 1.296 1.178 -0.415
ENSG00000015133 E036 13.3448751 0.0014816890 1.612132e-01 2.766828e-01 14 91339884 91340024 141 - 1.190 1.111 -0.281
ENSG00000015133 E037 0.9555373 0.0268811787 2.671046e-01 4.053846e-01 14 91342143 91342379 237 - 0.143 0.371 1.785
ENSG00000015133 E038 11.8346121 0.0118961042 1.363560e-01 2.429760e-01 14 91342380 91342463 84 - 1.167 1.061 -0.384
ENSG00000015133 E039 11.0672978 0.0015902478 1.329449e-02 3.660544e-02 14 91343599 91343657 59 - 1.178 0.985 -0.701
ENSG00000015133 E040 12.2504101 0.0020096958 2.004505e-02 5.158280e-02 14 91359642 91359711 70 - 1.211 1.042 -0.608
ENSG00000015133 E041 0.0000000       14 91378641 91378658 18 -      
ENSG00000015133 E042 5.2737276 0.0896302174 2.129400e-01 3.419962e-01 14 91378659 91379885 1227 - 0.884 0.707 -0.701
ENSG00000015133 E043 0.9221261 0.1955135441 3.687404e-01 5.131471e-01 14 91384390 91384551 162 - 0.143 0.364 1.744
ENSG00000015133 E044 0.1817044 0.0395958755 7.577381e-01   14 91408130 91408658 529 - 0.000 0.104 10.666
ENSG00000015133 E045 14.4146693 0.0012731218 1.298339e-02 3.587229e-02 14 91408659 91408767 109 - 1.270 1.102 -0.596
ENSG00000015133 E046 9.8815800 0.0017538679 1.161907e-02 3.262580e-02 14 91416738 91416838 101 - 1.143 0.934 -0.768
ENSG00000015133 E047 0.0000000       14 91417161 91417346 186 -      
ENSG00000015133 E048 6.2398108 0.0027438928 1.428861e-02 3.888324e-02 14 91417631 91417844 214 - 0.983 0.727 -0.990