ENSG00000014824

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000505523 ENSG00000014824 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A9 protein_coding retained_intron 26.29214 9.624441 47.08389 1.635604 1.874323 2.289267 0.4012695 1.495880 0.04952398 1.4958801 0.03200621 -4.660992 0.0351875 0.1163667 0.001033333 -0.1153333 0.8338855614 0.0006698312 FALSE  
ENST00000509683 ENSG00000014824 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A9 protein_coding retained_intron 26.29214 9.624441 47.08389 1.635604 1.874323 2.289267 2.8129494 1.558389 4.23581036 0.2218637 0.38078592 1.436756 0.1286458 0.1633333 0.089633333 -0.0737000 0.0006698312 0.0006698312 TRUE  
MSTRG.24796.3 ENSG00000014824 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A9 protein_coding   26.29214 9.624441 47.08389 1.635604 1.874323 2.289267 21.1617515 4.949919 40.97842323 0.9125744 1.27752977 3.046828 0.7353125 0.5709333 0.871066667 0.3001333 0.1625580824 0.0006698312 TRUE  
MSTRG.24796.5 ENSG00000014824 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC30A9 protein_coding   26.29214 9.624441 47.08389 1.635604 1.874323 2.289267 1.1602742 1.351562 0.67313532 0.8888157 0.37173386 -0.995019 0.0698000 0.1190333 0.013766667 -0.1052667 0.6351656900 0.0006698312 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000014824 E001 0.1515154 0.0436830114 1.000000e+00   4 41990484 41990494 11 + 0.051 0.000 -7.094
ENSG00000014824 E002 0.6685028 0.0164914659 1.014972e-01 1.927498e-01 4 41990495 41990501 7 + 0.096 0.433 2.786
ENSG00000014824 E003 1.4260800 0.3248709364 5.258716e-01 6.591906e-01 4 41990502 41990513 12 + 0.273 0.434 0.971
ENSG00000014824 E004 1.7227681 0.2071071610 7.164148e-01 8.120734e-01 4 41990514 41990514 1 + 0.327 0.433 0.610
ENSG00000014824 E005 5.8256193 0.0206212736 5.881684e-01 7.113874e-01 4 41990515 41990526 12 + 0.685 0.843 0.635
ENSG00000014824 E006 13.2590595 0.0022104374 9.859883e-01 9.952534e-01 4 41990527 41990529 3 + 1.007 1.083 0.276
ENSG00000014824 E007 180.4970204 0.0156723161 4.762612e-02 1.049550e-01 4 41990530 41990760 231 + 2.122 2.056 -0.221
ENSG00000014824 E008 280.1446594 0.0157522290 4.083275e-03 1.337594e-02 4 42001616 42001780 165 + 2.318 2.199 -0.396
ENSG00000014824 E009 135.0181056 0.0007453575 3.098790e-08 3.476176e-07 4 42018111 42018113 3 + 2.010 1.825 -0.621
ENSG00000014824 E010 199.9340835 0.0002057381 1.724802e-08 2.035372e-07 4 42018114 42018170 57 + 2.173 2.046 -0.423
ENSG00000014824 E011 0.4783925 0.0213848770 3.964925e-01 5.402508e-01 4 42018389 42018505 117 + 0.096 0.268 1.786
ENSG00000014824 E012 226.6220702 0.0066601307 6.464295e-03 1.983000e-02 4 42020416 42020515 100 + 2.220 2.156 -0.214
ENSG00000014824 E013 0.0000000       4 42020516 42020775 260 +      
ENSG00000014824 E014 236.0026837 0.0026095062 2.528037e-05 1.531005e-04 4 42022838 42022930 93 + 2.241 2.147 -0.315
ENSG00000014824 E015 191.1395903 0.0002374262 1.991306e-06 1.549778e-05 4 42023302 42023384 83 + 2.150 2.056 -0.316
ENSG00000014824 E016 162.9437669 0.0002474152 3.011662e-03 1.030079e-02 4 42035275 42035333 59 + 2.075 2.043 -0.107
ENSG00000014824 E017 174.1844952 0.0011464180 2.181598e-02 5.529356e-02 4 42038986 42039053 68 + 2.099 2.090 -0.029
ENSG00000014824 E018 207.9600545 0.0002054285 1.150666e-02 3.236580e-02 4 42049377 42049479 103 + 2.174 2.173 -0.005
ENSG00000014824 E019 210.8869548 0.0002131745 1.198136e-04 6.131038e-04 4 42060191 42060246 56 + 2.186 2.136 -0.166
ENSG00000014824 E020 183.2559858 0.0002137001 4.312884e-06 3.113095e-05 4 42062986 42063033 48 + 2.131 2.040 -0.307
ENSG00000014824 E021 229.4324227 0.0002013924 4.698310e-03 1.509122e-02 4 42063034 42063121 88 + 2.216 2.209 -0.026
ENSG00000014824 E022 183.0731586 0.0004336026 8.057401e-03 2.392518e-02 4 42065310 42065349 40 + 2.120 2.105 -0.049
ENSG00000014824 E023 213.1245139 0.0025037555 9.463259e-02 1.823315e-01 4 42066550 42066621 72 + 2.181 2.197 0.052
ENSG00000014824 E024 261.1880081 0.0028597157 5.366883e-01 6.684237e-01 4 42067085 42067192 108 + 2.262 2.321 0.196
ENSG00000014824 E025 1.7630631 0.0095091836 9.902145e-02 1.889727e-01 4 42070189 42070292 104 + 0.396 0.000 -10.657
ENSG00000014824 E026 352.2174906 0.0006731999 1.221071e-03 4.711945e-03 4 42070526 42070691 166 + 2.402 2.393 -0.028
ENSG00000014824 E027 313.5420634 0.0001493025 2.135134e-02 5.432887e-02 4 42075657 42075786 130 + 2.348 2.370 0.074
ENSG00000014824 E028 269.7470665 0.0001693590 2.756210e-02 6.713671e-02 4 42078212 42078325 114 + 2.261 2.408 0.490
ENSG00000014824 E029 42.2009833 0.0006025320 4.653009e-17 2.083921e-15 4 42078326 42078851 526 + 1.346 1.923 1.967
ENSG00000014824 E030 1222.0082514 0.0253270761 6.899801e-05 3.752179e-04 4 42086082 42088622 2541 + 2.872 3.206 1.111
ENSG00000014824 E031 16.7468627 0.0011001058 3.493769e-01 4.935971e-01 4 42088623 42089603 981 + 1.080 1.257 0.632
ENSG00000014824 E032 5.1026974 0.0232465429 7.298183e-02 1.482987e-01 4 42089604 42089768 165 + 0.586 0.940 1.436
ENSG00000014824 E033 4.2241595 0.0120639504 5.059115e-03 1.609191e-02 4 42089769 42090095 327 + 0.475 0.980 2.108
ENSG00000014824 E034 2.6227455 0.0057690736 4.169124e-02 9.417064e-02 4 42090096 42090461 366 + 0.374 0.787 1.910
ENSG00000014824 E035 0.1451727 0.0433398160 1.000000e+00   4 42091225 42091285 61 + 0.051 0.000 -7.072
ENSG00000014824 E036 3.5959528 0.1142794305 7.145732e-01 8.107207e-01 4 42098042 42098261 220 + 0.525 0.651 0.567