ENSG00000014216

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279247 ENSG00000014216 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPN1 protein_coding protein_coding 46.64063 80.27299 31.03765 4.596928 1.322345 -1.37061 37.3148177 67.895909 21.967109 2.9825675 0.4349009 -1.627535 0.77258750 0.84720000 0.70966667 -0.137533333 0.0008720622 4.837366e-09 FALSE TRUE
ENST00000529133 ENSG00000014216 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPN1 protein_coding protein_coding 46.64063 80.27299 31.03765 4.596928 1.322345 -1.37061 0.7522317 0.000000 2.259715 0.0000000 1.2337088 7.826367 0.02402083 0.00000000 0.06976667 0.069766667 0.1085244408 4.837366e-09 FALSE FALSE
ENST00000533820 ENSG00000014216 HEK293_OSMI2_2hA HEK293_TMG_2hB CAPN1 protein_coding protein_coding 46.64063 80.27299 31.03765 4.596928 1.322345 -1.37061 3.5420086 5.877147 2.256818 0.5930903 0.5454846 -1.376900 0.07679167 0.07283333 0.07400000 0.001166667 0.9784188323 4.837366e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000014216 E001 0.0000000       11 65180566 65180645 80 +      
ENSG00000014216 E002 0.0000000       11 65181037 65181055 19 +      
ENSG00000014216 E003 29.5194700 0.0051455110 1.068463e-01 2.008903e-01 11 65181194 65181410 217 + 1.484 1.358 -0.433
ENSG00000014216 E004 3.3463368 0.0051626195 8.212256e-01 8.872982e-01 11 65181687 65181722 36 + 0.526 0.568 0.193
ENSG00000014216 E005 3.8977795 0.0044011987 5.674373e-01 6.942381e-01 11 65181723 65181732 10 + 0.526 0.627 0.456
ENSG00000014216 E006 4.1944677 0.0042203844 8.415659e-01 9.011800e-01 11 65181733 65181744 12 + 0.657 0.627 -0.129
ENSG00000014216 E007 6.5237302 0.0027506279 5.970212e-01 7.188592e-01 11 65181745 65181782 38 + 0.839 0.767 -0.280
ENSG00000014216 E008 4.5642060 0.0035703042 9.844211e-01 9.943305e-01 11 65181783 65181786 4 + 0.657 0.662 0.023
ENSG00000014216 E009 5.5908191 0.0029603013 8.556337e-01 9.107378e-01 11 65181787 65181799 13 + 0.710 0.740 0.122
ENSG00000014216 E010 5.5939396 0.0030389172 5.425814e-01 6.733070e-01 11 65181800 65181806 7 + 0.657 0.754 0.401
ENSG00000014216 E011 10.7805634 0.0099171515 5.272974e-01 6.604054e-01 11 65181807 65181843 37 + 0.907 0.993 0.320
ENSG00000014216 E012 8.7576179 0.0020709338 3.160513e-01 4.588225e-01 11 65181919 65181927 9 + 0.993 0.873 -0.451
ENSG00000014216 E013 9.4907545 0.0018635071 7.364193e-02 1.493616e-01 11 65181928 65181930 3 + 1.086 0.884 -0.753
ENSG00000014216 E014 10.1121296 0.0017122986 2.117903e-02 5.397379e-02 11 65181931 65181933 3 + 1.145 0.894 -0.926
ENSG00000014216 E015 12.2898767 0.0014539943 2.984538e-02 7.166091e-02 11 65181934 65181937 4 + 1.197 0.975 -0.803
ENSG00000014216 E016 19.1349856 0.0009662722 2.006116e-02 5.161470e-02 11 65181938 65181943 6 + 1.358 1.161 -0.695
ENSG00000014216 E017 137.9390822 0.0002586572 6.344300e-04 2.660149e-03 11 65181944 65181999 56 + 2.135 2.019 -0.390
ENSG00000014216 E018 141.0470256 0.0002600540 1.411305e-04 7.084645e-04 11 65182000 65182013 14 + 2.154 2.026 -0.429
ENSG00000014216 E019 5.8971463 0.0169708097 3.883400e-01 5.324350e-01 11 65182014 65182308 295 + 0.839 0.713 -0.502
ENSG00000014216 E020 0.4720498 0.2070205996 1.551210e-01 2.685607e-01 11 65182384 65182434 51 + 0.338 0.072 -2.708
ENSG00000014216 E021 0.3268771 0.0294245127 3.845078e-01   11 65182435 65182452 18 + 0.201 0.072 -1.714
ENSG00000014216 E022 0.3268771 0.0294245127 3.845078e-01   11 65182453 65182461 9 + 0.201 0.072 -1.714
ENSG00000014216 E023 0.6224193 0.0172671820 2.489573e-01 3.847031e-01 11 65182462 65182480 19 + 0.338 0.133 -1.716
ENSG00000014216 E024 0.7655156 0.2152318456 1.572260e-01 2.714072e-01 11 65182481 65182541 61 + 0.441 0.132 -2.308
ENSG00000014216 E025 0.4355181 0.6132023454 6.868721e-02 1.411925e-01 11 65182542 65182562 21 + 0.440 0.000 -12.709
ENSG00000014216 E026 0.5838113 0.4082093489 1.213755e-01 2.218877e-01 11 65182563 65182579 17 + 0.441 0.070 -3.323
ENSG00000014216 E027 1.0652225 0.2941104034 7.552405e-01 8.406465e-01 11 65182580 65182700 121 + 0.338 0.269 -0.452
ENSG00000014216 E028 393.4821523 0.0001468724 2.421377e-04 1.142266e-03 11 65182701 65182901 201 + 2.555 2.480 -0.249
ENSG00000014216 E029 274.7018389 0.0002111410 1.819272e-01 3.036327e-01 11 65182902 65182968 67 + 2.366 2.334 -0.105
ENSG00000014216 E030 316.9788201 0.0001787589 3.875506e-04 1.726765e-03 11 65183128 65183197 70 + 2.466 2.385 -0.269
ENSG00000014216 E031 2.0220947 0.0075216760 4.702771e-02 1.038750e-01 11 65183336 65183473 138 + 0.657 0.318 -1.713
ENSG00000014216 E032 440.7425012 0.0014172917 1.112761e-08 1.360059e-07 11 65183474 65183592 119 + 2.657 2.514 -0.475
ENSG00000014216 E033 0.6632174 0.0217045689 9.387757e-01 9.655432e-01 11 65183593 65183668 76 + 0.201 0.187 -0.131
ENSG00000014216 E034 1.6982389 0.0097498553 2.741524e-02 6.683484e-02 11 65185891 65185916 26 + 0.657 0.278 -1.980
ENSG00000014216 E035 252.5961083 0.0038976581 8.722413e-05 4.619870e-04 11 65185917 65185931 15 + 2.421 2.272 -0.495
ENSG00000014216 E036 436.1112863 0.0013067056 1.621336e-04 8.011615e-04 11 65185932 65186050 119 + 2.615 2.523 -0.307
ENSG00000014216 E037 1.0223597 0.2481215563 8.031076e-01 8.746656e-01 11 65186051 65186169 119 + 0.201 0.278 0.604
ENSG00000014216 E038 444.0653737 0.0008197462 1.776090e-02 4.662384e-02 11 65186170 65186338 169 + 2.591 2.540 -0.172
ENSG00000014216 E039 368.2393018 0.0023819498 7.577894e-02 1.527488e-01 11 65187215 65187298 84 + 2.511 2.459 -0.171
ENSG00000014216 E040 3.7840689 0.6703730034 1.825748e-01 3.044419e-01 11 65187299 65187686 388 + 0.871 0.487 -1.637
ENSG00000014216 E041 1.8456758 0.0099184575 5.046856e-03 1.605912e-02 11 65187941 65187954 14 + 0.710 0.235 -2.520
ENSG00000014216 E042 415.2966780 0.0002628975 8.717707e-03 2.558113e-02 11 65187955 65188040 86 + 2.562 2.509 -0.176
ENSG00000014216 E043 2.9527285 0.0052073659 1.493176e-02 4.033255e-02 11 65188245 65188413 169 + 0.800 0.418 -1.715
ENSG00000014216 E044 426.6882945 0.0001753958 2.187322e-05 1.343737e-04 11 65188414 65188488 75 + 2.596 2.513 -0.279
ENSG00000014216 E045 510.4100436 0.0012891597 5.074266e-02 1.104922e-01 11 65188586 65188746 161 + 2.644 2.601 -0.143
ENSG00000014216 E046 0.1482932 0.0417984118 1.000000e+00   11 65203372 65203454 83 + 0.000 0.072 9.550
ENSG00000014216 E047 0.1482932 0.0417984118 1.000000e+00   11 65203545 65203638 94 + 0.000 0.072 9.550
ENSG00000014216 E048 443.8523095 0.0005460267 9.701744e-01 9.853402e-01 11 65204683 65204858 176 + 2.546 2.549 0.011
ENSG00000014216 E049 204.7594060 0.0002209407 3.904766e-02 8.928525e-02 11 65205710 65205721 12 + 2.161 2.228 0.226
ENSG00000014216 E050 5.9955755 0.0086764031 1.086838e-04 5.620871e-04 11 65205722 65206075 354 + 1.107 0.608 -1.950
ENSG00000014216 E051 6.7631515 0.0084557721 1.392530e-03 5.282448e-03 11 65206257 65206462 206 + 1.087 0.680 -1.567
ENSG00000014216 E052 324.9719610 0.0001495363 4.425656e-01 5.841721e-01 11 65206463 65206537 75 + 2.397 2.418 0.072
ENSG00000014216 E053 462.5157537 0.0001596817 6.930475e-01 7.941362e-01 11 65206538 65206674 137 + 2.556 2.568 0.038
ENSG00000014216 E054 293.5796806 0.0001728248 2.282899e-02 5.738813e-02 11 65206780 65206819 40 + 2.318 2.380 0.209
ENSG00000014216 E055 379.5299983 0.0003551985 2.487591e-02 6.161718e-02 11 65208055 65208120 66 + 2.434 2.491 0.191
ENSG00000014216 E056 431.4074735 0.0001709099 2.592345e-04 1.213671e-03 11 65208205 65208262 58 + 2.469 2.552 0.277
ENSG00000014216 E057 3.7622499 0.0041759416 2.413755e-02 6.009787e-02 11 65208478 65208949 472 + 0.839 0.499 -1.450
ENSG00000014216 E058 2.1550494 0.0681836440 1.914943e-03 6.962082e-03 11 65208950 65209143 194 + 0.800 0.237 -2.872
ENSG00000014216 E059 2.4850469 0.0106929325 2.949874e-03 1.011649e-02 11 65209144 65209322 179 + 0.800 0.318 -2.298
ENSG00000014216 E060 417.4572500 0.0007012961 1.047725e-03 4.124435e-03 11 65209323 65209387 65 + 2.454 2.540 0.287
ENSG00000014216 E061 3.6192725 0.0050772429 4.401317e-07 3.935880e-06 11 65209388 65209848 461 + 1.042 0.318 -3.217
ENSG00000014216 E062 476.2552293 0.0011621038 1.569852e-04 7.783195e-04 11 65209849 65209917 69 + 2.498 2.601 0.344
ENSG00000014216 E063 5.2804054 0.0425126053 1.327118e-01 2.378718e-01 11 65209918 65210017 100 + 0.907 0.661 -0.979
ENSG00000014216 E064 454.5563951 0.0009993420 7.225465e-05 3.911203e-04 11 65210018 65210096 79 + 2.475 2.582 0.355
ENSG00000014216 E065 472.6467081 0.0007843288 1.910216e-03 6.947565e-03 11 65210336 65210452 117 + 2.515 2.594 0.264
ENSG00000014216 E066 398.0935773 0.0002465665 9.177997e-05 4.833201e-04 11 65210814 65210872 59 + 2.426 2.521 0.314
ENSG00000014216 E067 5.6087387 0.0775204440 3.936273e-01 5.375143e-01 11 65210873 65211259 387 + 0.838 0.700 -0.554
ENSG00000014216 E068 1202.1950046 0.0011479650 1.919594e-17 9.057569e-16 11 65211260 65212006 747 + 2.838 3.014 0.585