ENSG00000014123

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369278 ENSG00000014123 HEK293_OSMI2_2hA HEK293_TMG_2hB UFL1 protein_coding protein_coding 10.36197 2.789554 15.98288 0.06231322 0.8401482 2.514161 9.5596609 1.389360 15.3710349 0.08568725 0.6093211 3.458313 0.7763083 0.4987333 0.96313333 0.4644 1.201705e-08 1.201705e-08 FALSE TRUE
ENST00000461673 ENSG00000014123 HEK293_OSMI2_2hA HEK293_TMG_2hB UFL1 protein_coding processed_transcript 10.36197 2.789554 15.98288 0.06231322 0.8401482 2.514161 0.8023103 1.400194 0.6118437 0.11344823 0.2329240 -1.181269 0.2236917 0.5012667 0.03686667 -0.4644 1.239297e-08 1.201705e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000014123 E001 1.172907 0.1925586212 1.559745e-01 2.697643e-01 6 96521595 96521805 211 + 0.162 0.531 2.402
ENSG00000014123 E002 46.280210 0.0044600004 4.353941e-04 1.910504e-03 6 96521806 96521950 145 + 1.391 1.727 1.150
ENSG00000014123 E003 6.563208 0.0353663782 2.136671e-20 1.431857e-18 6 96522863 96522964 102 + 0.237 1.566 5.624
ENSG00000014123 E004 64.724222 0.0023293887 3.572047e-03 1.193351e-02 6 96523146 96523291 146 + 1.585 1.386 -0.684
ENSG00000014123 E005 45.723766 0.0005142101 2.197648e-03 7.834883e-03 6 96524382 96524410 29 + 1.442 1.176 -0.931
ENSG00000014123 E006 69.101288 0.0004865478 3.070407e-02 7.333603e-02 6 96525297 96525394 98 + 1.606 1.496 -0.378
ENSG00000014123 E007 80.277893 0.0003555213 1.820710e-03 6.665790e-03 6 96526321 96526435 115 + 1.674 1.496 -0.608
ENSG00000014123 E008 82.425345 0.0003280217 4.880047e-04 2.114230e-03 6 96528502 96528632 131 + 1.687 1.479 -0.709
ENSG00000014123 E009 58.190128 0.0004987595 5.223311e-02 1.131323e-01 6 96534263 96534321 59 + 1.532 1.426 -0.365
ENSG00000014123 E010 79.125172 0.0004044488 1.408325e-02 3.841102e-02 6 96536244 96536390 147 + 1.664 1.542 -0.415
ENSG00000014123 E011 77.169197 0.0027772597 1.109810e-02 3.140076e-02 6 96537374 96537549 176 + 1.656 1.512 -0.491
ENSG00000014123 E012 87.938834 0.0003357810 1.430644e-03 5.409198e-03 6 96538631 96538810 180 + 1.713 1.542 -0.583
ENSG00000014123 E013 69.841933 0.0003341211 4.055044e-05 2.333772e-04 6 96540535 96540655 121 + 1.623 1.319 -1.046
ENSG00000014123 E014 75.816799 0.0003374457 1.736054e-03 6.396153e-03 6 96542894 96543016 123 + 1.650 1.462 -0.641
ENSG00000014123 E015 72.593011 0.0003335595 3.946927e-03 1.299344e-02 6 96548164 96548281 118 + 1.632 1.462 -0.580
ENSG00000014123 E016 74.872457 0.0045290266 1.961529e-02 5.066338e-02 6 96549412 96549578 167 + 1.644 1.511 -0.452
ENSG00000014123 E017 62.043388 0.0004295000 2.443519e-01 3.792974e-01 6 96549669 96549799 131 + 1.558 1.527 -0.106
ENSG00000014123 E018 49.261693 0.0005602000 6.837224e-01 7.868516e-01 6 96551433 96551513 81 + 1.454 1.479 0.089
ENSG00000014123 E019 54.618231 0.0004138951 4.358144e-01 5.779831e-01 6 96551838 96551923 86 + 1.500 1.496 -0.013
ENSG00000014123 E020 78.948462 0.0003791942 8.508426e-01 9.075172e-01 6 96552482 96552662 181 + 1.650 1.699 0.166
ENSG00000014123 E021 310.286801 0.0034338204 9.925527e-28 1.373529e-25 6 96553285 96555276 1992 + 2.188 2.599 1.373