ENSG00000013619

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358892 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding protein_coding 3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.01601002 0.0000000 0.12808017 0.00000000 0.12808017 3.7874342 0.007266667 0.0000000 0.05813333 0.05813333 6.490940e-01 3.040704e-13 FALSE TRUE
ENST00000370401 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding protein_coding 3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.41830164 0.0000000 0.38185012 0.00000000 0.20434352 5.2922300 0.149833333 0.0000000 0.19716667 0.19716667 1.071434e-01 3.040704e-13 FALSE TRUE
ENST00000426613 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding protein_coding 3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.05608874 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.055916667 0.0000000 0.00000000 0.00000000   3.040704e-13 FALSE TRUE
ENST00000464149 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding retained_intron 3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.60161309 1.0576534 0.07554007 0.23411217 0.05470424 -3.6416992 0.146133333 0.2065667 0.03543333 -0.17113333 2.253284e-02 3.040704e-13 FALSE TRUE
ENST00000682016 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding protein_coding 3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.15342058 0.4772650 0.00000000 0.25306841 0.00000000 -5.6066347 0.076937500 0.0993000 0.00000000 -0.09930000 2.753154e-01 3.040704e-13 FALSE TRUE
ENST00000683696 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding protein_coding 3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.96884313 1.3633846 0.73875133 0.21676913 0.27528463 -0.8751771 0.321037500 0.2651000 0.35630000 0.09120000 7.814033e-01 3.040704e-13 FALSE TRUE
MSTRG.35034.11 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding   3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.25352095 1.1877850 0.00000000 0.05536441 0.00000000 -6.9042251 0.051570833 0.2345333 0.00000000 -0.23453333 3.040704e-13 3.040704e-13 FALSE TRUE
MSTRG.35034.12 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding   3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.04679350 0.0000000 0.11721339 0.00000000 0.11721339 3.6691786 0.018795833 0.0000000 0.05963333 0.05963333 6.621502e-01 3.040704e-13 FALSE TRUE
MSTRG.35034.8 ENSG00000013619 HEK293_OSMI2_2hA HEK293_TMG_2hB MAMLD1 protein_coding   3.042536 5.079782 2.020368 0.3463885 0.0936094 -1.325863 0.41522370 0.8088034 0.45865247 0.10355868 0.24272183 -0.8049986 0.131075000 0.1621000 0.23873333 0.07663333 1.000000e+00 3.040704e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000013619 E001 0.0000000       X 150361422 150361571 150 +      
ENSG00000013619 E002 0.0000000       X 150361572 150361699 128 +      
ENSG00000013619 E003 0.0000000       X 150362010 150362040 31 +      
ENSG00000013619 E004 0.0000000       X 150362041 150362212 172 +      
ENSG00000013619 E005 0.0000000       X 150362213 150362219 7 +      
ENSG00000013619 E006 0.0000000       X 150362318 150362816 499 +      
ENSG00000013619 E007 0.1817044 0.0398711868 1.000000e+00   X 150362817 150362886 70 + 0.000 0.084 7.952
ENSG00000013619 E008 2.1014772 0.0069718438 2.063975e-02 5.282687e-02 X 150363287 150363316 30 + 0.696 0.316 -1.889
ENSG00000013619 E009 2.1014772 0.0069718438 2.063975e-02 5.282687e-02 X 150363317 150363327 11 + 0.696 0.316 -1.889
ENSG00000013619 E010 3.1313124 0.0049110702 4.301852e-02 9.657680e-02 X 150363328 150363363 36 + 0.775 0.466 -1.362
ENSG00000013619 E011 5.9723932 0.0028342363 1.341062e-02 3.687108e-02 X 150363364 150363530 167 + 0.996 0.686 -1.210
ENSG00000013619 E012 0.1472490 0.0436359148 2.084796e-01   X 150420999 150421117 119 + 0.175 0.000 -12.267
ENSG00000013619 E013 9.3326409 0.0146289580 6.625000e-04 2.761284e-03 X 150445454 150445612 159 + 1.213 0.818 -1.462
ENSG00000013619 E014 6.4390135 0.0027418281 5.122401e-01 6.471518e-01 X 150462772 150462846 75 + 0.871 0.788 -0.325
ENSG00000013619 E015 13.0797388 0.0014139430 4.854772e-04 2.104627e-03 X 150469745 150469865 121 + 1.308 0.990 -1.139
ENSG00000013619 E016 42.1485640 0.0017456092 8.016751e-04 3.265496e-03 X 150469866 150470425 560 + 1.708 1.523 -0.630
ENSG00000013619 E017 68.9912380 0.0005600806 7.433483e-02 1.504799e-01 X 150470426 150471418 993 + 1.838 1.763 -0.252
ENSG00000013619 E018 13.7965999 0.0014000189 4.213059e-03 1.373896e-02 X 150471419 150471490 72 + 1.286 1.027 -0.928
ENSG00000013619 E019 13.6781654 0.0013851291 7.094245e-02 1.449039e-01 X 150473680 150473802 123 + 1.226 1.060 -0.596
ENSG00000013619 E020 30.9145719 0.0030116299 2.335364e-02 5.848506e-02 X 150503274 150503517 244 + 1.546 1.395 -0.519
ENSG00000013619 E021 4.4974432 0.0916945445 2.337239e-01 3.668094e-01 X 150509325 150509961 637 + 0.474 0.734 1.158
ENSG00000013619 E022 23.7712999 0.0009006728 6.838608e-01 7.869583e-01 X 150509962 150510046 85 + 1.358 1.329 -0.100
ENSG00000013619 E023 262.7842335 0.0004576643 2.715689e-22 2.232014e-20 X 150512004 150514178 2175 + 2.215 2.406 0.638