ENSG00000013573

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537136 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding retained_intron 86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 5.255514 4.280613 3.459246 0.6419782 0.5909526 -0.3065617 0.05897500 0.05370000 0.05356667 -0.0001333333 1.000000e+00 1.388526e-06 FALSE FALSE
ENST00000538345 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding nonsense_mediated_decay 86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 4.502285 6.153660 1.517267 0.6199322 0.3931980 -2.0128354 0.05288750 0.07823333 0.02410000 -0.0541333333 1.815053e-03 1.388526e-06 FALSE TRUE
ENST00000538740 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding retained_intron 86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 5.434140 2.882750 4.668653 0.3129201 0.1833483 0.6936516 0.06144583 0.03630000 0.07353333 0.0372333333 1.388526e-06 1.388526e-06   FALSE
ENST00000539699 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding retained_intron 86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 5.117748 1.704790 3.015317 0.8694692 0.7531311 0.8190542 0.05689583 0.02083333 0.04633333 0.0255000000 6.390828e-01 1.388526e-06 FALSE TRUE
ENST00000539702 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding protein_coding 86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 12.591019 17.355649 7.280005 2.2157764 0.6946359 -1.2522445 0.14150833 0.21973333 0.11376667 -0.1059666667 1.623797e-03 1.388526e-06 FALSE TRUE
ENST00000542777 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding retained_intron 86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 6.486264 3.217567 4.944583 0.5813123 0.6053744 0.6183163 0.07265417 0.04016667 0.07760000 0.0374333333 1.353896e-02 1.388526e-06   FALSE
ENST00000542838 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding protein_coding 86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 6.077024 11.617792 4.289883 2.3874519 0.8102559 -1.4352080 0.08008750 0.14520000 0.06883333 -0.0763666667 1.005567e-01 1.388526e-06 FALSE TRUE
MSTRG.7070.5 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding   86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 4.660483 2.687725 4.217090 0.1476128 0.6355235 0.6479216 0.05525417 0.03406667 0.06566667 0.0316000000 1.752194e-03 1.388526e-06 FALSE TRUE
MSTRG.7070.6 ENSG00000013573 HEK293_OSMI2_2hA HEK293_TMG_2hB DDX11 protein_coding   86.06593 78.96168 63.74163 5.092928 3.820452 -0.3088731 8.663942 6.368632 5.908980 0.5342206 0.5347645 -0.1078985 0.09766667 0.08126667 0.09340000 0.0121333333 7.652295e-01 1.388526e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000013573 E001 2.5295408 0.0755314061 7.807001e-02 1.563769e-01 12 31073852 31073855 4 + 0.257 0.621 1.978
ENSG00000013573 E002 4.0730420 0.0212615032 1.868053e-01 3.097160e-01 12 31073856 31073859 4 + 0.534 0.757 0.962
ENSG00000013573 E003 11.7823494 0.0221619683 3.357263e-02 7.891655e-02 12 31073860 31073867 8 + 1.224 0.987 -0.857
ENSG00000013573 E004 27.1402622 0.0167309702 7.207713e-01 8.153236e-01 12 31073868 31073875 8 + 1.441 1.423 -0.063
ENSG00000013573 E005 27.9882914 0.0144681939 8.947246e-01 9.367154e-01 12 31073876 31073878 3 + 1.441 1.444 0.008
ENSG00000013573 E006 32.0742121 0.0144683864 5.787893e-01 7.037910e-01 12 31073879 31073881 3 + 1.522 1.489 -0.112
ENSG00000013573 E007 39.0105366 0.0066404903 2.841038e-01 4.243199e-01 12 31073882 31073890 9 + 1.621 1.561 -0.203
ENSG00000013573 E008 43.1457273 0.0042305389 2.537050e-02 6.263752e-02 12 31073891 31073891 1 + 1.701 1.577 -0.422
ENSG00000013573 E009 60.3080955 0.0052182996 1.488880e-02 4.023793e-02 12 31073892 31073893 2 + 1.843 1.717 -0.426
ENSG00000013573 E010 63.0256598 0.0060264633 2.279056e-02 5.731054e-02 12 31073894 31073897 4 + 1.858 1.738 -0.402
ENSG00000013573 E011 65.7410459 0.0062184767 4.228984e-02 9.525359e-02 12 31073898 31073901 4 + 1.867 1.763 -0.352
ENSG00000013573 E012 69.4126142 0.0012935504 6.782998e-03 2.065847e-02 12 31073902 31073908 7 + 1.893 1.783 -0.371
ENSG00000013573 E013 99.6634539 0.0015975019 1.217258e-03 4.698573e-03 12 31073909 31073969 61 + 2.051 1.934 -0.391
ENSG00000013573 E014 117.6100960 0.0004073897 3.224695e-03 1.092919e-02 12 31073970 31074054 85 + 2.105 2.019 -0.289
ENSG00000013573 E015 92.7762416 0.0018008958 7.001766e-02 1.433999e-01 12 31074055 31074091 37 + 1.991 1.929 -0.207
ENSG00000013573 E016 2.4156924 0.1199010924 8.764556e-01 9.247153e-01 12 31074214 31074219 6 + 0.479 0.531 0.248
ENSG00000013573 E017 8.6168316 0.0345202908 3.777306e-01 5.220342e-01 12 31074220 31074255 36 + 1.029 0.923 -0.395
ENSG00000013573 E018 11.9537858 0.0332354778 5.731896e-02 1.220170e-01 12 31074256 31074261 6 + 1.224 0.999 -0.810
ENSG00000013573 E019 14.9303868 0.0529937999 1.040894e-01 1.967379e-01 12 31074262 31074263 2 + 1.300 1.102 -0.705
ENSG00000013573 E020 34.0436948 0.0161396073 1.590472e-01 2.738486e-01 12 31074264 31074327 64 + 1.586 1.483 -0.354
ENSG00000013573 E021 15.1216758 0.0011668840 3.079521e-01 4.501833e-01 12 31077945 31078107 163 + 1.234 1.158 -0.272
ENSG00000013573 E022 8.6981595 0.0071450666 9.462171e-01 9.702396e-01 12 31078108 31078177 70 + 0.958 0.961 0.013
ENSG00000013573 E023 7.3173621 0.0296123655 7.180721e-01 8.132804e-01 12 31078178 31078194 17 + 0.917 0.882 -0.135
ENSG00000013573 E024 17.7338478 0.0013990239 4.774065e-01 6.159523e-01 12 31078195 31078288 94 + 1.283 1.237 -0.160
ENSG00000013573 E025 96.9206706 0.0039103279 6.112219e-01 7.303761e-01 12 31078390 31078414 25 + 1.978 1.969 -0.030
ENSG00000013573 E026 109.7772419 0.0005045216 5.147667e-02 1.117757e-01 12 31078415 31078462 48 + 2.060 2.005 -0.185
ENSG00000013573 E027 117.7819358 0.0003506917 6.598886e-03 2.018321e-02 12 31078463 31078519 57 + 2.104 2.026 -0.260
ENSG00000013573 E028 73.8442687 0.0003617039 6.116679e-02 1.285892e-01 12 31078520 31078537 18 + 1.895 1.830 -0.218
ENSG00000013573 E029 78.8487989 0.0005053379 9.220614e-02 1.785729e-01 12 31083813 31083827 15 + 1.917 1.861 -0.187
ENSG00000013573 E030 113.2207124 0.0030351235 1.994242e-02 5.136894e-02 12 31083828 31083876 49 + 2.091 2.006 -0.284
ENSG00000013573 E031 162.0737077 0.0002591593 1.016051e-03 4.014262e-03 12 31083877 31083966 90 + 2.240 2.159 -0.270
ENSG00000013573 E032 158.7242828 0.0013517875 2.683890e-01 4.068421e-01 12 31083967 31084061 95 + 2.193 2.170 -0.077
ENSG00000013573 E033 131.9301891 0.0002462585 5.187949e-01 6.529791e-01 12 31084583 31084669 87 + 2.075 2.110 0.117
ENSG00000013573 E034 2.9285272 0.2031624819 7.513820e-01 8.378433e-01 12 31084798 31084911 114 + 0.533 0.596 0.286
ENSG00000013573 E035 99.5098032 0.0004073972 1.934665e-01 3.181291e-01 12 31084969 31085009 41 + 1.935 1.999 0.212
ENSG00000013573 E036 175.3894244 0.0002287323 8.899304e-02 1.735923e-01 12 31085010 31085126 117 + 2.182 2.244 0.209
ENSG00000013573 E037 6.7126972 0.0024625341 4.982420e-01 6.347325e-01 12 31086014 31086024 11 + 0.796 0.893 0.379
ENSG00000013573 E038 20.7177265 0.0009256335 8.365952e-01 8.978154e-01 12 31086025 31086212 188 + 1.292 1.321 0.103
ENSG00000013573 E039 9.8690889 0.0049211954 8.073690e-01 8.776265e-01 12 31087109 31087311 203 + 1.012 0.998 -0.054
ENSG00000013573 E040 5.3821280 0.0029629124 3.067594e-02 7.328455e-02 12 31087576 31087644 69 + 0.938 0.670 -1.062
ENSG00000013573 E041 16.4353814 0.0150103314 5.591326e-04 2.381590e-03 12 31087645 31087937 293 + 1.395 1.065 -1.166
ENSG00000013573 E042 170.1984576 0.0006707891 4.112839e-01 5.548751e-01 12 31087938 31087983 46 + 2.217 2.207 -0.034
ENSG00000013573 E043 139.7174316 0.0026357550 5.686495e-02 1.212304e-01 12 31089044 31089068 25 + 2.162 2.104 -0.194
ENSG00000013573 E044 209.0311101 0.0010776852 5.888416e-02 1.247211e-01 12 31089069 31089151 83 + 2.325 2.285 -0.133
ENSG00000013573 E045 37.2497219 0.0005517277 1.354174e-13 3.777152e-12 12 31089152 31089402 251 + 1.781 1.372 -1.396
ENSG00000013573 E046 158.5325739 0.0012448269 2.383700e-02 5.947383e-02 12 31089403 31089490 88 + 2.215 2.156 -0.198
ENSG00000013573 E047 91.2287479 0.0027819405 8.238801e-11 1.474833e-09 12 31089491 31089839 349 + 2.098 1.823 -0.923
ENSG00000013573 E048 34.3537746 0.0056248249 2.512620e-03 8.802092e-03 12 31089840 31089885 46 + 1.641 1.445 -0.671
ENSG00000013573 E049 74.2245146 0.0003622807 5.657953e-01 6.928421e-01 12 31089886 31089890 5 + 1.858 1.847 -0.036
ENSG00000013573 E050 189.7745309 0.0028454254 9.681379e-01 9.840851e-01 12 31089891 31090094 204 + 2.245 2.260 0.051
ENSG00000013573 E051 0.4751703 0.0221460637 8.618417e-01 9.149271e-01 12 31091037 31091273 237 + 0.147 0.183 0.377
ENSG00000013573 E052 1.2628095 0.0252883831 1.867096e-01 3.096088e-01 12 31091553 31091718 166 + 0.480 0.252 -1.361
ENSG00000013573 E053 153.4731200 0.0074496446 5.018023e-01 6.379426e-01 12 31091719 31091871 153 + 2.178 2.159 -0.063
ENSG00000013573 E054 93.0147030 0.0029239906 4.023903e-01 5.461188e-01 12 31092846 31092861 16 + 1.963 1.939 -0.080
ENSG00000013573 E055 102.6076061 0.0014541146 5.271515e-01 6.602936e-01 12 31092862 31092892 31 + 1.998 1.987 -0.038
ENSG00000013573 E056 74.5721757 0.0003812393 2.222647e-01 3.531136e-01 12 31093245 31093248 4 + 1.877 1.839 -0.128
ENSG00000013573 E057 107.9668787 0.0002780376 4.829939e-01 6.210878e-01 12 31093249 31093324 76 + 2.022 2.011 -0.037
ENSG00000013573 E058 8.9802683 0.0022513928 6.763957e-04 2.812641e-03 12 31093325 31093720 396 + 1.168 0.814 -1.316
ENSG00000013573 E059 9.5341938 0.0110968745 1.729716e-03 6.376274e-03 12 31094295 31094589 295 + 1.192 0.848 -1.267
ENSG00000013573 E060 81.4375369 0.0032606431 5.809090e-01 7.055711e-01 12 31094590 31094634 45 + 1.865 1.908 0.144
ENSG00000013573 E061 83.1277704 0.0006493960 3.267713e-01 4.702197e-01 12 31094755 31094792 38 + 1.919 1.893 -0.087
ENSG00000013573 E062 96.8263009 0.0002869844 8.113086e-01 8.802624e-01 12 31094793 31094822 30 + 1.953 1.976 0.076
ENSG00000013573 E063 128.0306398 0.0002574566 5.777146e-01 7.029341e-01 12 31096341 31096379 39 + 2.068 2.100 0.108
ENSG00000013573 E064 2.1893038 0.0122514793 1.715870e-01 2.902715e-01 12 31096635 31096636 2 + 0.626 0.410 -1.040
ENSG00000013573 E065 211.7559805 0.0002018157 2.779947e-01 4.176236e-01 12 31096637 31096745 109 + 2.277 2.319 0.140
ENSG00000013573 E066 173.9988182 0.0014660307 6.912674e-02 1.419297e-01 12 31096859 31096913 55 + 2.168 2.243 0.252
ENSG00000013573 E067 211.8315161 0.0004105367 3.014470e-01 4.432664e-01 12 31096914 31096990 77 + 2.275 2.317 0.139
ENSG00000013573 E068 210.4690610 0.0019826258 8.446285e-02 1.665425e-01 12 31097885 31097997 113 + 2.251 2.324 0.243
ENSG00000013573 E069 8.9147902 0.0470934931 3.133503e-02 7.455152e-02 12 31100407 31100559 153 + 1.131 0.840 -1.079
ENSG00000013573 E070 12.6268800 0.0013654330 2.749280e-02 6.699289e-02 12 31100560 31100634 75 + 1.224 1.030 -0.697
ENSG00000013573 E071 157.0966740 0.0112973996 1.650418e-01 2.817502e-01 12 31100635 31100707 73 + 2.108 2.208 0.333
ENSG00000013573 E072 25.7663041 0.0008264819 1.850640e-02 4.824458e-02 12 31100708 31100904 197 + 1.495 1.347 -0.511
ENSG00000013573 E073 16.5729245 0.0325553660 5.167754e-02 1.121425e-01 12 31100999 31101026 28 + 1.357 1.139 -0.769
ENSG00000013573 E074 114.5267283 0.0120044950 3.879303e-01 5.320411e-01 12 31101027 31101044 18 + 1.989 2.063 0.247
ENSG00000013573 E075 190.7763748 0.0019190041 2.750712e-01 4.143235e-01 12 31101045 31101130 86 + 2.223 2.275 0.176
ENSG00000013573 E076 39.2837577 0.0019575403 9.301778e-13 2.295173e-11 12 31101131 31101475 345 + 1.803 1.400 -1.375
ENSG00000013573 E077 31.2380662 0.0017718900 3.371182e-12 7.589547e-11 12 31101513 31101832 320 + 1.718 1.287 -1.483
ENSG00000013573 E078 215.0603411 0.0017486733 1.667693e-01 2.839808e-01 12 31101833 31101982 150 + 2.273 2.333 0.199
ENSG00000013573 E079 10.1889357 0.0018357044 5.805961e-02 1.233082e-01 12 31102214 31102242 29 + 1.131 0.948 -0.669
ENSG00000013573 E080 136.8499680 0.0002495010 1.253163e-02 3.480946e-02 12 31102243 31102267 25 + 2.052 2.147 0.317
ENSG00000013573 E081 142.9451932 0.0002852525 3.888267e-03 1.283154e-02 12 31102268 31102311 44 + 2.065 2.171 0.355
ENSG00000013573 E082 4.2414449 0.0739583958 8.615645e-01 9.147201e-01 12 31102312 31102335 24 + 0.666 0.717 0.214
ENSG00000013573 E083 128.0956268 0.0002679708 6.380815e-04 2.673389e-03 12 31102427 31102450 24 + 2.000 2.129 0.433
ENSG00000013573 E084 171.3823785 0.0002518878 2.242200e-04 1.067201e-03 12 31102451 31102527 77 + 2.132 2.254 0.408
ENSG00000013573 E085 7.9263314 0.0643500480 3.762385e-01 5.205873e-01 12 31102528 31102729 202 + 1.013 0.880 -0.498
ENSG00000013573 E086 108.1980718 0.0014654009 1.215948e-04 6.211277e-04 12 31102936 31102974 39 + 1.897 2.069 0.577
ENSG00000013573 E087 124.2242734 0.0002817153 5.369246e-05 3.001793e-04 12 31102975 31103020 46 + 1.969 2.122 0.514
ENSG00000013573 E088 33.8835753 0.0010273333 5.625537e-01 6.901280e-01 12 31103021 31103218 198 + 1.528 1.505 -0.078
ENSG00000013573 E089 88.3525132 0.0003062834 2.487051e-02 6.160688e-02 12 31103317 31103321 5 + 1.855 1.959 0.349
ENSG00000013573 E090 161.9865064 0.0002106405 5.825177e-02 1.236277e-01 12 31103322 31103395 74 + 2.141 2.211 0.234
ENSG00000013573 E091 11.4526437 0.0040199967 1.047100e-02 2.991012e-02 12 31103396 31103460 65 + 1.224 0.984 -0.866
ENSG00000013573 E092 262.0169918 0.0002015867 4.300785e-04 1.890332e-03 12 31103577 31103731 155 + 2.331 2.428 0.324
ENSG00000013573 E093 62.6397668 0.0031439758 1.161807e-02 3.262444e-02 12 31103732 31103806 75 + 1.855 1.740 -0.389
ENSG00000013573 E094 1056.6627060 0.0049888930 1.442582e-05 9.235359e-05 12 31103807 31104799 993 + 2.889 3.054 0.549