ENSG00000013563

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000014935 ENSG00000013563 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1L1 protein_coding protein_coding 36.62464 65.75652 24.25688 1.957815 0.6675433 -1.438365 7.408756 12.14679 3.056460 1.4747125 0.3982697 -1.987116 0.2008708 0.1845333 0.1253000 -0.05923333 0.20883130 0.01259008 FALSE  
ENST00000309585 ENSG00000013563 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1L1 protein_coding protein_coding 36.62464 65.75652 24.25688 1.957815 0.6675433 -1.438365 14.526910 29.55463 9.561301 1.2640334 0.3241037 -1.627085 0.3782125 0.4505667 0.3955333 -0.05503333 0.53962534 0.01259008 FALSE  
ENST00000424626 ENSG00000013563 HEK293_OSMI2_2hA HEK293_TMG_2hB DNASE1L1 protein_coding protein_coding 36.62464 65.75652 24.25688 1.957815 0.6675433 -1.438365 9.143343 14.87462 7.336139 0.8432245 0.5162645 -1.018765 0.2597417 0.2258333 0.3018000 0.07596667 0.01259008 0.01259008 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000013563 E001 0.2214452 0.0391584404 1.000000e+00   X 154401236 154401237 2 - 0.000 0.072 7.765
ENSG00000013563 E002 11.6791188 0.0207445274 2.249934e-01 3.564086e-01 X 154401238 154401757 520 - 0.873 1.056 0.684
ENSG00000013563 E003 4.9179626 0.0289237867 5.005419e-01 6.367804e-01 X 154401758 154401760 3 - 0.595 0.725 0.553
ENSG00000013563 E004 858.8438140 0.0033131469 5.432085e-05 3.033433e-04 X 154401761 154402486 726 - 2.735 2.863 0.425
ENSG00000013563 E005 354.8720884 0.0003820925 1.766548e-03 6.493099e-03 X 154402487 154402721 235 - 2.384 2.475 0.303
ENSG00000013563 E006 243.1407732 0.0010111312 1.865185e-02 4.856829e-02 X 154402722 154402841 120 - 2.222 2.311 0.298
ENSG00000013563 E007 21.5077942 0.0009050322 2.439917e-01 3.788904e-01 X 154402842 154402941 100 - 1.162 1.283 0.430
ENSG00000013563 E008 267.5788869 0.0010787182 3.921599e-01 5.360963e-01 X 154402942 154403091 150 - 2.300 2.341 0.136
ENSG00000013563 E009 195.6601882 0.0025988907 3.560741e-01 5.004609e-01 X 154403092 154403137 46 - 2.213 2.193 -0.067
ENSG00000013563 E010 223.1979953 0.0001899606 6.150821e-02 1.291742e-01 X 154403138 154403190 53 - 2.284 2.247 -0.126
ENSG00000013563 E011 303.6064153 0.0003537039 8.506586e-03 2.505437e-02 X 154403269 154403381 113 - 2.426 2.375 -0.168
ENSG00000013563 E012 283.5151751 0.0002338594 7.407308e-03 2.227802e-02 X 154403522 154403622 101 - 2.399 2.347 -0.174
ENSG00000013563 E013 239.1286311 0.0012756804 9.230914e-01 9.554976e-01 X 154404828 154404914 87 - 2.271 2.288 0.058
ENSG00000013563 E014 228.4746625 0.0039756202 3.332733e-01 4.769712e-01 X 154404995 154405083 89 - 2.286 2.260 -0.086
ENSG00000013563 E015 173.6117082 0.0019483020 2.659624e-01 4.040851e-01 X 154405434 154405488 55 - 2.168 2.140 -0.092
ENSG00000013563 E016 306.1702039 0.0002107561 6.118695e-02 1.286236e-01 X 154405489 154405655 167 - 2.415 2.384 -0.102
ENSG00000013563 E017 6.6918076 0.1187606882 9.089870e-01 9.461806e-01 X 154408558 154409111 554 - 0.800 0.811 0.043
ENSG00000013563 E018 177.3805170 0.0002741411 4.739047e-01 6.127952e-01 X 154409112 154409196 85 - 2.163 2.154 -0.028
ENSG00000013563 E019 2.7085659 0.2221302671 5.513211e-01 6.808078e-01 X 154409197 154409278 82 - 0.597 0.458 -0.659
ENSG00000013563 E020 275.5421936 0.0016985397 5.436323e-03 1.711500e-02 X 154409418 154409675 258 - 2.400 2.329 -0.237
ENSG00000013563 E021 53.0905778 0.0054005921 9.601409e-01 9.789089e-01 X 154409676 154409813 138 - 1.625 1.635 0.036
ENSG00000013563 E022 36.2920533 0.0140467175 3.646801e-01 5.090147e-01 X 154409814 154410039 226 - 1.389 1.490 0.348
ENSG00000013563 E023 203.4532825 0.0002249447 5.880179e-06 4.120976e-05 X 154411891 154412112 222 - 2.304 2.189 -0.383