ENSG00000013561

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394514 ENSG00000013561 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF14 protein_coding protein_coding 20.17929 9.913039 31.68373 2.002454 0.2853619 1.675343 2.9756949 0.7502009 5.0640365 0.4072722 0.6653335 2.738681 0.14030417 0.06913333 0.16020000 0.09106667 0.48265283 0.001992991 FALSE TRUE
ENST00000394520 ENSG00000013561 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF14 protein_coding protein_coding 20.17929 9.913039 31.68373 2.002454 0.2853619 1.675343 2.0180120 3.3943624 0.6387532 0.7108836 0.6387532 -2.391643 0.14045833 0.34153333 0.01996667 -0.32156667 0.01568547 0.001992991 FALSE TRUE
ENST00000502341 ENSG00000013561 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF14 protein_coding processed_transcript 20.17929 9.913039 31.68373 2.002454 0.2853619 1.675343 0.5571661 0.4600238 0.0000000 0.3131902 0.0000000 -5.554662 0.02661250 0.05833333 0.00000000 -0.05833333 0.12547214 0.001992991 FALSE FALSE
ENST00000506938 ENSG00000013561 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF14 protein_coding protein_coding 20.17929 9.913039 31.68373 2.002454 0.2853619 1.675343 1.8998014 0.2319405 4.9597142 0.2319405 0.5395040 4.360438 0.07062083 0.02950000 0.15663333 0.12713333 0.10125971 0.001992991 FALSE TRUE
MSTRG.27082.9 ENSG00000013561 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF14 protein_coding   20.17929 9.913039 31.68373 2.002454 0.2853619 1.675343 9.8442701 3.8872677 16.1803529 0.9759645 0.5629890 2.054599 0.47719167 0.38520000 0.51073333 0.12553333 0.01782319 0.001992991 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000013561 E001 0.0000000       5 141958328 141958336 9 +      
ENSG00000013561 E002 0.2966881 0.0272976320 5.267142e-01   5 141958337 141958425 89 + 0.160 0.000 -9.189
ENSG00000013561 E003 0.1472490 0.0463324541 1.000000e+00   5 141966820 141966836 17 + 0.087 0.000 -9.861
ENSG00000013561 E004 0.1472490 0.0463324541 1.000000e+00   5 141966837 141966904 68 + 0.087 0.000 -9.861
ENSG00000013561 E005 0.7813216 0.0302917400 2.253128e-01 3.567862e-01 5 141968886 141969050 165 + 0.160 0.384 1.674
ENSG00000013561 E006 4.4550981 0.0149517000 5.757227e-01 7.012546e-01 5 141969051 141969089 39 + 0.754 0.681 -0.303
ENSG00000013561 E007 5.3742055 0.0049577909 6.095995e-01 7.290742e-01 5 141969090 141969094 5 + 0.817 0.760 -0.229
ENSG00000013561 E008 6.1784178 0.0026476913 4.882871e-01 6.258735e-01 5 141969095 141969103 9 + 0.873 0.794 -0.305
ENSG00000013561 E009 7.2920037 0.0027214638 2.990372e-01 4.405196e-01 5 141969104 141969104 1 + 0.944 0.826 -0.450
ENSG00000013561 E010 7.9164993 0.0020916831 4.309917e-01 5.735880e-01 5 141969105 141969110 6 + 0.966 0.884 -0.308
ENSG00000013561 E011 23.8742225 0.0169486798 1.243196e-01 2.261569e-01 5 141969111 141969135 25 + 1.429 1.270 -0.555
ENSG00000013561 E012 30.2057014 0.0073806380 3.003124e-02 7.202046e-02 5 141969136 141969150 15 + 1.531 1.359 -0.591
ENSG00000013561 E013 35.6686620 0.0413035810 1.977305e-01 3.233919e-01 5 141969151 141969156 6 + 1.600 1.430 -0.581
ENSG00000013561 E014 42.2844561 0.0299176183 2.931142e-01 4.341507e-01 5 141969157 141969167 11 + 1.659 1.537 -0.416
ENSG00000013561 E015 2.1101117 0.1241823281 6.453339e-01 7.574440e-01 5 141969168 141969234 67 + 0.509 0.390 -0.619
ENSG00000013561 E016 0.5138669 0.0224397579 1.000000e+00 1.000000e+00 5 141969269 141969276 8 + 0.160 0.169 0.097
ENSG00000013561 E017 1.1404508 0.0115665904 3.877954e-02 8.877504e-02 5 141969277 141969385 109 + 0.160 0.528 2.415
ENSG00000013561 E018 1.8465321 0.0079515207 2.249495e-01 3.563557e-01 5 141969386 141969617 232 + 0.369 0.585 1.092
ENSG00000013561 E019 94.6981087 0.0016286722 3.428065e-02 8.029593e-02 5 141970704 141970877 174 + 1.995 1.914 -0.270
ENSG00000013561 E020 165.8477495 0.0003742555 2.011831e-04 9.688241e-04 5 141973583 141973742 160 + 2.242 2.145 -0.325
ENSG00000013561 E021 136.9039685 0.0007998782 1.673855e-01 2.848018e-01 5 141974804 141974955 152 + 2.140 2.104 -0.118
ENSG00000013561 E022 328.5574701 0.0005845197 1.241605e-02 3.453761e-02 5 141978303 141978830 528 + 2.521 2.479 -0.143
ENSG00000013561 E023 168.3844839 0.0072889675 2.844540e-01 4.246903e-01 5 141980123 141980310 188 + 2.230 2.194 -0.119
ENSG00000013561 E024 93.9093224 0.0089492990 2.403865e-01 3.745939e-01 5 141980311 141980351 41 + 1.986 1.933 -0.178
ENSG00000013561 E025 194.8358784 0.0037510637 1.175354e-01 2.164193e-01 5 141983380 141983552 173 + 2.298 2.253 -0.149
ENSG00000013561 E026 179.0896242 0.0002568718 9.417938e-01 9.674092e-01 5 141984803 141984933 131 + 2.242 2.260 0.058
ENSG00000013561 E027 229.1675006 0.0003117174 2.655074e-02 6.505629e-02 5 141987733 141987975 243 + 2.329 2.396 0.224
ENSG00000013561 E028 71.8096968 0.0115982813 3.398533e-04 1.539739e-03 5 141987976 141988095 120 + 1.753 1.982 0.771
ENSG00000013561 E029 348.6903372 0.0027088115 2.150405e-09 2.995498e-08 5 141988096 141990292 2197 + 2.459 2.640 0.603
ENSG00000013561 E030 0.6696487 0.0404213434 7.911758e-01 8.664424e-01 5 142010975 142011089 115 + 0.222 0.169 -0.487