ENSG00000013441

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321356 ENSG00000013441 HEK293_OSMI2_2hA HEK293_TMG_2hB CLK1 protein_coding protein_coding 31.02446 12.39064 49.59653 1.304194 1.12659 2.000115 9.862766 3.6213812 20.509116 0.46165538 0.7454896 2.4983783 0.28094583 0.29136667 0.41346667 0.122100000 0.001092342 0.001092342 FALSE TRUE
ENST00000409769 ENSG00000013441 HEK293_OSMI2_2hA HEK293_TMG_2hB CLK1 protein_coding protein_coding 31.02446 12.39064 49.59653 1.304194 1.12659 2.000115 2.346347 2.3357791 1.761746 1.16662939 0.5142209 -0.4048955 0.11194583 0.17563333 0.03553333 -0.140100000 0.061715854 0.001092342 FALSE TRUE
ENST00000432425 ENSG00000013441 HEK293_OSMI2_2hA HEK293_TMG_2hB CLK1 protein_coding nonsense_mediated_decay 31.02446 12.39064 49.59653 1.304194 1.12659 2.000115 5.099641 1.8101064 8.901794 0.52929405 0.5147690 2.2916930 0.15795000 0.15100000 0.17930000 0.028300000 0.776804504 0.001092342 FALSE TRUE
ENST00000461326 ENSG00000013441 HEK293_OSMI2_2hA HEK293_TMG_2hB CLK1 protein_coding retained_intron 31.02446 12.39064 49.59653 1.304194 1.12659 2.000115 1.614574 0.3218927 1.686694 0.32189272 0.1900272 2.3539374 0.06043750 0.03256667 0.03390000 0.001333333 0.403900554 0.001092342   FALSE
ENST00000461981 ENSG00000013441 HEK293_OSMI2_2hA HEK293_TMG_2hB CLK1 protein_coding retained_intron 31.02446 12.39064 49.59653 1.304194 1.12659 2.000115 2.079823 0.7138804 3.360191 0.07136962 0.2264981 2.2190071 0.06801667 0.05770000 0.06786667 0.010166667 0.721553858 0.001092342 TRUE TRUE
ENST00000473565 ENSG00000013441 HEK293_OSMI2_2hA HEK293_TMG_2hB CLK1 protein_coding retained_intron 31.02446 12.39064 49.59653 1.304194 1.12659 2.000115 5.254537 1.4967163 7.356767 0.25216992 0.6402277 2.2896238 0.15360417 0.12120000 0.14806667 0.026866667 0.599751382 0.001092342 FALSE TRUE
ENST00000496205 ENSG00000013441 HEK293_OSMI2_2hA HEK293_TMG_2hB CLK1 protein_coding retained_intron 31.02446 12.39064 49.59653 1.304194 1.12659 2.000115 2.666663 1.4483080 3.452036 0.21206739 0.1685011 1.2473252 0.09619167 0.12080000 0.06956667 -0.051233333 0.151293823 0.001092342   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000013441 E001 1.220990 0.0110376027 3.486016e-04 1.574554e-03 2 200853009 200853075 67 - 0.068 0.675 4.457
ENSG00000013441 E002 1.072697 0.0121989077 1.440007e-03 5.439456e-03 2 200853076 200853076 1 - 0.068 0.614 4.195
ENSG00000013441 E003 1.072697 0.0121989077 1.440007e-03 5.439456e-03 2 200853077 200853080 4 - 0.068 0.614 4.195
ENSG00000013441 E004 1.581278 0.0094640748 3.875989e-04 1.726858e-03 2 200853081 200853081 1 - 0.127 0.729 3.680
ENSG00000013441 E005 1.581278 0.0094640748 3.875989e-04 1.726858e-03 2 200853082 200853097 16 - 0.127 0.729 3.680
ENSG00000013441 E006 2.838786 0.0055722927 2.637096e-08 3.003427e-07 2 200853098 200853112 15 - 0.127 0.988 4.680
ENSG00000013441 E007 47.986968 0.0007461643 7.498610e-15 2.517659e-13 2 200853113 200853195 83 - 1.483 1.900 1.414
ENSG00000013441 E008 53.624210 0.0005380312 1.978894e-14 6.233712e-13 2 200853196 200853246 51 - 1.544 1.933 1.315
ENSG00000013441 E009 101.606028 0.0062613552 1.206883e-06 9.851366e-06 2 200853247 200853331 85 - 1.868 2.133 0.887
ENSG00000013441 E010 158.984491 0.0058044789 8.091662e-05 4.323137e-04 2 200853332 200853449 118 - 2.084 2.281 0.657
ENSG00000013441 E011 207.011265 0.0030656346 2.493614e-03 8.744890e-03 2 200853903 200853993 91 - 2.223 2.344 0.406
ENSG00000013441 E012 7.885638 0.0027819401 4.015198e-03 1.318428e-02 2 200853994 200854134 141 - 0.785 1.129 1.286
ENSG00000013441 E013 211.706808 0.0004483493 8.142569e-03 2.414477e-02 2 200854616 200854695 80 - 2.244 2.325 0.270
ENSG00000013441 E014 13.004030 0.0019619004 2.443128e-02 6.071349e-02 2 200854696 200854886 191 - 1.022 1.251 0.819
ENSG00000013441 E015 188.701797 0.0002154288 1.958801e-02 5.060221e-02 2 200855004 200855086 83 - 2.195 2.268 0.244
ENSG00000013441 E016 224.581661 0.0002359592 7.031851e-02 1.438792e-01 2 200856682 200856811 130 - 2.276 2.330 0.180
ENSG00000013441 E017 169.791029 0.0002668399 7.381724e-01 8.281196e-01 2 200856891 200856985 95 - 2.167 2.183 0.054
ENSG00000013441 E018 49.307403 0.0011307041 2.327655e-02 5.832438e-02 2 200856986 200857717 732 - 1.670 1.531 -0.472
ENSG00000013441 E019 220.670878 0.0026269609 5.451961e-01 6.755952e-01 2 200857718 200857884 167 - 2.287 2.270 -0.057
ENSG00000013441 E020 218.354579 0.0016546601 1.440441e-01 2.535211e-01 2 200857973 200858089 117 - 2.289 2.245 -0.148
ENSG00000013441 E021 7.406356 0.0092260148 6.329048e-01 7.477000e-01 2 200858090 200858166 77 - 0.883 0.820 -0.242
ENSG00000013441 E022 169.627553 0.0004399685 3.264746e-01 4.699141e-01 2 200859680 200859746 67 - 2.174 2.146 -0.092
ENSG00000013441 E023 86.281776 0.0004513827 8.724461e-02 1.709608e-01 2 200859747 200860124 378 - 1.854 1.933 0.267
ENSG00000013441 E024 146.213417 0.0026309951 3.208921e-03 1.088157e-02 2 200860125 200860215 91 - 2.129 2.007 -0.409
ENSG00000013441 E025 140.900591 0.0126064661 1.762356e-01 2.963414e-01 2 200860216 200860964 749 - 2.105 2.026 -0.265
ENSG00000013441 E026 38.006190 0.0039249641 2.035520e-03 7.336965e-03 2 200860965 200861089 125 - 1.577 1.334 -0.837
ENSG00000013441 E027 41.348785 0.0005392765 2.408937e-04 1.137134e-03 2 200861090 200861237 148 - 1.614 1.358 -0.881
ENSG00000013441 E028 156.100324 0.0036197101 2.519578e-06 1.917898e-05 2 200861238 200861331 94 - 2.175 1.960 -0.721
ENSG00000013441 E029 180.674547 0.0014689119 3.144655e-09 4.250771e-08 2 200861332 200861466 135 - 2.239 2.017 -0.743
ENSG00000013441 E030 2.648872 0.0084904548 6.928370e-01 7.939617e-01 2 200861467 200861701 235 - 0.529 0.458 -0.349
ENSG00000013441 E031 176.844906 0.0002521362 3.807146e-16 1.519300e-14 2 200861702 200861862 161 - 2.241 1.958 -0.949
ENSG00000013441 E032 6.928203 0.0027532882 8.538469e-01 9.095800e-01 2 200864101 200864563 463 - 0.842 0.820 -0.086
ENSG00000013441 E033 105.592294 0.0003144437 1.150088e-11 2.370008e-10 2 200864564 200864691 128 - 2.022 1.711 -1.045