ENSG00000013375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000507404 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding retained_intron 19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 0.6295228 0.1703927 0.9818679 0.17039266 0.2068516 2.4590073 0.05257083 0.02993333 0.02860000 -0.001333333 6.207683e-01 1.679953e-09   FALSE
ENST00000509219 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding protein_coding 19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 1.5482924 0.9431323 1.7314678 0.07991102 0.1780937 0.8695554 0.10209583 0.16350000 0.05023333 -0.113266667 5.120798e-07 1.679953e-09 FALSE TRUE
ENST00000512866 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding protein_coding 19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 3.6637052 0.6610985 7.6165453 0.12059435 0.8814080 3.5064333 0.15245833 0.11610000 0.22136667 0.105266667 7.052002e-02 1.679953e-09 FALSE TRUE
ENST00000513973 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding protein_coding 19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 5.3163577 1.9271039 9.5295546 0.07344409 0.3635288 2.3000205 0.29035000 0.33483333 0.27693333 -0.057900000 3.159981e-01 1.679953e-09 FALSE TRUE
ENST00000605602 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding protein_coding 19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 0.8888582 0.7231179 0.9286560 0.16192904 0.2663106 0.3565513 0.05081667 0.12653333 0.02693333 -0.099600000 3.159405e-03 1.679953e-09   FALSE
ENST00000650640 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding nonsense_mediated_decay 19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 1.3305794 0.0000000 2.4581338 0.00000000 0.2562134 7.9472768 0.04514583 0.00000000 0.07146667 0.071466667 1.679953e-09 1.679953e-09 FALSE TRUE
ENST00000650642 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding protein_coding 19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 2.0337665 0.6614644 3.4670960 0.33585593 0.9543010 2.3725000 0.09753333 0.11153333 0.10036667 -0.011166667 9.537847e-01 1.679953e-09 FALSE TRUE
ENST00000651698 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding nonsense_mediated_decay 19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 0.8071255 0.4829664 0.7620313 0.03532796 0.3962730 0.6471698 0.05784167 0.08360000 0.02223333 -0.061366667 3.478004e-01 1.679953e-09 FALSE TRUE
MSTRG.28598.5 ENSG00000013375 HEK293_OSMI2_2hA HEK293_TMG_2hB PGM3 protein_coding   19.31482 5.768509 34.42442 0.1948734 0.2579395 2.575082 0.7930837 0.0000000 3.0099396 0.00000000 1.5129884 8.2383759 0.02837917 0.00000000 0.08750000 0.087500000 3.702310e-01 1.679953e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000013375 E001 0.2924217 0.0273016530 1.000000e+00   6 83161150 83161242 93 - 0.109 0.001 -7.777
ENSG00000013375 E002 13.6524954 0.0349971636 9.301634e-03 2.703622e-02 6 83164873 83165037 165 - 0.974 1.324 1.256
ENSG00000013375 E003 144.6939522 0.0006752355 4.001743e-06 2.911248e-05 6 83165038 83166129 1092 - 2.020 2.191 0.571
ENSG00000013375 E004 47.1338327 0.0005071208 4.178550e-01 5.611734e-01 6 83166130 83166279 150 - 1.566 1.621 0.187
ENSG00000013375 E005 55.0050397 0.0004071009 7.258772e-01 8.190454e-01 6 83166280 83166466 187 - 1.648 1.629 -0.064
ENSG00000013375 E006 17.2022543 0.0010471012 2.554218e-01 3.923085e-01 6 83166467 83166524 58 - 1.180 1.056 -0.445
ENSG00000013375 E007 220.6987920 0.0011418056 1.449280e-01 2.547403e-01 6 83166525 83167793 1269 - 2.231 2.280 0.166
ENSG00000013375 E008 82.0349303 0.0052841230 3.552573e-01 4.996282e-01 6 83167794 83168266 473 - 1.802 1.855 0.179
ENSG00000013375 E009 73.3542740 0.0003533907 7.495442e-01 8.364636e-01 6 83168267 83168527 261 - 1.768 1.753 -0.049
ENSG00000013375 E010 100.6209365 0.0008661330 2.730996e-02 6.662362e-02 6 83168528 83168902 375 - 1.919 1.812 -0.362
ENSG00000013375 E011 23.2170786 0.0008145509 7.130835e-01 8.096342e-01 6 83168903 83168908 6 - 1.288 1.257 -0.111
ENSG00000013375 E012 29.1969576 0.0007861120 5.341156e-01 6.662317e-01 6 83168909 83168927 19 - 1.388 1.338 -0.174
ENSG00000013375 E013 45.9351701 0.0004624358 5.083020e-01 6.437468e-01 6 83168928 83168972 45 - 1.560 1.605 0.156
ENSG00000013375 E014 32.5620572 0.0005972546 1.727597e-01 2.917838e-01 6 83168973 83168973 1 - 1.403 1.507 0.359
ENSG00000013375 E015 55.6698886 0.0005090999 2.746542e-04 1.276619e-03 6 83168974 83169062 89 - 1.607 1.811 0.693
ENSG00000013375 E016 44.9779454 0.0043746851 1.575313e-03 5.879169e-03 6 83169063 83169122 60 - 1.515 1.733 0.744
ENSG00000013375 E017 70.3029451 0.0003481527 2.249049e-02 5.670278e-02 6 83169123 83169241 119 - 1.725 1.845 0.404
ENSG00000013375 E018 75.2026952 0.0003820590 9.059486e-01 9.442007e-01 6 83169242 83169323 82 - 1.777 1.786 0.030
ENSG00000013375 E019 0.4751703 0.0207977415 5.057749e-02 1.101870e-01 6 83169521 83169568 48 - 0.058 0.395 3.375
ENSG00000013375 E020 7.0623949 0.0024831577 3.187803e-07 2.933073e-06 6 83169569 83169841 273 - 0.617 1.238 2.376
ENSG00000013375 E021 2.0044789 0.0075527464 2.008045e-01 3.271992e-01 6 83170301 83170304 4 - 0.359 0.598 1.205
ENSG00000013375 E022 149.8788126 0.0002075768 6.699091e-01 7.765400e-01 6 83170305 83170478 174 - 2.070 2.089 0.062
ENSG00000013375 E023 127.2950121 0.0002696227 4.366239e-01 5.786692e-01 6 83171937 83172059 123 - 2.008 1.979 -0.098
ENSG00000013375 E024 96.2991976 0.0003034692 3.229442e-01 4.663065e-01 6 83174374 83174436 63 - 1.873 1.921 0.160
ENSG00000013375 E025 80.4359457 0.0003188039 6.720039e-01 7.781065e-01 6 83174437 83174487 51 - 1.802 1.826 0.081
ENSG00000013375 E026 107.1992522 0.0002708635 9.691494e-01 9.847169e-01 6 83175962 83176060 99 - 1.928 1.932 0.015
ENSG00000013375 E027 1.3985321 0.0111546520 6.421904e-01 7.550303e-01 6 83176061 83176135 75 - 0.301 0.395 0.570
ENSG00000013375 E028 93.5675293 0.0002981087 7.683403e-01 8.503184e-01 6 83178673 83178756 84 - 1.874 1.863 -0.038
ENSG00000013375 E029 131.2444742 0.0002350954 5.314029e-02 1.147385e-01 6 83179810 83179967 158 - 2.031 1.954 -0.258
ENSG00000013375 E030 63.1820438 0.0004989757 1.969919e-01 3.224595e-01 6 83181736 83181761 26 - 1.717 1.643 -0.250
ENSG00000013375 E031 153.4942852 0.0002028831 1.854222e-05 1.159176e-04 6 83181762 83181931 170 - 2.111 1.943 -0.564
ENSG00000013375 E032 118.5121581 0.0002643294 2.191478e-01 3.493435e-01 6 83182845 83182949 105 - 1.982 1.932 -0.168
ENSG00000013375 E033 72.3271399 0.0014409395 4.833301e-01 6.213456e-01 6 83182950 83182978 29 - 1.755 1.796 0.139
ENSG00000013375 E034 68.5034268 0.0003886319 8.244582e-01 8.894103e-01 6 83187008 83187024 17 - 1.739 1.730 -0.032
ENSG00000013375 E035 86.3641073 0.0003728553 4.614398e-01 6.013965e-01 6 83187025 83187075 51 - 1.845 1.811 -0.114
ENSG00000013375 E036 4.9196342 0.0031774934 2.114886e-01 3.402478e-01 6 83188503 83188613 111 - 0.646 0.841 0.791
ENSG00000013375 E037 62.6073750 0.0004035284 4.259461e-01 5.688139e-01 6 83188614 83188616 3 - 1.709 1.665 -0.148
ENSG00000013375 E038 141.5297904 0.0002841070 7.290626e-01 8.213530e-01 6 83188617 83188744 128 - 2.052 2.041 -0.035
ENSG00000013375 E039 100.3136392 0.0003061621 3.932010e-01 5.370948e-01 6 83188745 83188794 50 - 1.908 1.872 -0.124
ENSG00000013375 E040 61.8395111 0.0005296668 9.888645e-02 1.887721e-01 6 83188795 83188798 4 - 1.711 1.613 -0.332
ENSG00000013375 E041 3.5794960 0.0048725708 6.489866e-02 1.348657e-01 6 83190510 83190808 299 - 0.632 0.241 -2.147
ENSG00000013375 E042 174.2886276 0.0002577946 9.581619e-03 2.773641e-02 6 83190809 83191014 206 - 2.155 2.064 -0.305
ENSG00000013375 E043 3.2579295 0.0048353682 8.879159e-02 1.732690e-01 6 83191187 83191323 137 - 0.602 0.241 -2.016
ENSG00000013375 E044 1.2576127 0.0102710873 5.303899e-01 6.630119e-01 6 83192962 83193104 143 - 0.269 0.395 0.792
ENSG00000013375 E045 0.9535377 0.0690503606 1.000000e+00 1.000000e+00 6 83193105 83193178 74 - 0.234 0.242 0.063
ENSG00000013375 E046 74.5982606 0.0004779508 3.370467e-03 1.135216e-02 6 83193179 83193293 115 - 1.802 1.636 -0.562
ENSG00000013375 E047 0.7623952 0.6199170649 6.458746e-01 7.579412e-01 6 83193823 83198888 5066 - 0.195 0.242 0.398