ENSG00000013306

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000225308 ENSG00000013306 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A39 protein_coding protein_coding 275.7543 486.167 167.1722 23.85802 4.124718 -1.540061 167.70783 326.72281 87.14951 17.123089 2.765974 -1.9063813 0.5706542 0.67183333 0.52116667 -0.15066667 1.690437e-16 3.308244e-33 FALSE TRUE
ENST00000377095 ENSG00000013306 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A39 protein_coding protein_coding 275.7543 486.167 167.1722 23.85802 4.124718 -1.540061 36.67602 69.04784 19.42136 1.205710 1.147136 -1.8294186 0.1318042 0.14246667 0.11660000 -0.02586667 2.758500e-01 3.308244e-33 FALSE TRUE
ENST00000591006 ENSG00000013306 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A39 protein_coding retained_intron 275.7543 486.167 167.1722 23.85802 4.124718 -1.540061 11.56036 8.44816 12.12929 1.119178 1.005303 0.5212683 0.0553125 0.01733333 0.07236667 0.05503333 2.223718e-15 3.308244e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000013306 E001 3.062223 9.963272e-03 3.778067e-01 5.221150e-01 17 44319625 44319626 2 - 0.663 0.517 -0.657
ENSG00000013306 E002 6.572444 6.264872e-02 6.322901e-01 7.471601e-01 17 44319627 44319627 1 - 0.717 0.824 0.429
ENSG00000013306 E003 83.341493 1.012230e-02 1.472595e-02 3.987404e-02 17 44319628 44319641 14 - 1.680 1.855 0.594
ENSG00000013306 E004 468.453320 1.298069e-03 7.171794e-02 1.462088e-01 17 44319642 44319672 31 - 2.528 2.580 0.174
ENSG00000013306 E005 501.427184 1.438180e-03 1.586594e-02 4.243617e-02 17 44319673 44319677 5 - 2.543 2.613 0.231
ENSG00000013306 E006 647.015571 1.300202e-03 1.143647e-01 2.119136e-01 17 44319678 44319690 13 - 2.676 2.718 0.143
ENSG00000013306 E007 2112.355948 2.150728e-03 7.592870e-05 4.087540e-04 17 44319691 44319819 129 - 3.141 3.242 0.335
ENSG00000013306 E008 2131.005841 1.968375e-03 1.135822e-04 5.842783e-04 17 44319820 44319869 50 - 3.150 3.245 0.317
ENSG00000013306 E009 2836.411799 2.131724e-03 2.777863e-05 1.665056e-04 17 44319870 44319994 125 - 3.268 3.370 0.341
ENSG00000013306 E010 2702.139388 2.506717e-04 6.105309e-20 3.841357e-18 17 44319995 44320116 122 - 3.242 3.349 0.355
ENSG00000013306 E011 2419.762250 5.554048e-04 2.569013e-09 3.530590e-08 17 44320196 44320276 81 - 3.208 3.298 0.298
ENSG00000013306 E012 118.828589 2.180758e-03 9.641799e-05 5.052304e-04 17 44320277 44320354 78 - 2.100 1.935 -0.556
ENSG00000013306 E013 2473.168554 8.648019e-04 1.572134e-03 5.868227e-03 17 44320355 44320436 82 - 3.246 3.302 0.188
ENSG00000013306 E014 1480.179716 1.565259e-04 1.678330e-02 4.445798e-02 17 44320622 44320628 7 - 3.042 3.074 0.108
ENSG00000013306 E015 2380.388516 5.377621e-05 2.377055e-03 8.389862e-03 17 44320629 44320731 103 - 3.248 3.279 0.100
ENSG00000013306 E016 101.851047 2.925537e-04 1.951482e-09 2.738537e-08 17 44320732 44320749 18 - 2.085 1.850 -0.789
ENSG00000013306 E017 119.207676 2.896396e-04 4.045954e-51 2.616020e-48 17 44320750 44320937 188 - 2.328 1.818 -1.712
ENSG00000013306 E018 91.003536 3.021292e-04 1.531951e-60 1.551998e-57 17 44320938 44321057 120 - 2.274 1.652 -2.089
ENSG00000013306 E019 3309.547473 4.143219e-05 3.669991e-04 1.646620e-03 17 44321058 44321231 174 - 3.392 3.422 0.099
ENSG00000013306 E020 132.491496 6.313177e-03 6.973058e-32 1.328999e-29 17 44321232 44321297 66 - 2.415 1.833 -1.951
ENSG00000013306 E021 188.763882 1.414014e-02 3.982486e-20 2.570597e-18 17 44321298 44321433 136 - 2.570 1.983 -1.960
ENSG00000013306 E022 2016.372893 8.256482e-05 2.715796e-01 4.103520e-01 17 44321434 44321476 43 - 3.191 3.204 0.044
ENSG00000013306 E023 2809.537929 1.400268e-04 5.386757e-01 6.700843e-01 17 44321477 44321558 82 - 3.349 3.345 -0.012
ENSG00000013306 E024 2273.855362 5.180392e-05 7.486026e-01 8.357870e-01 17 44321700 44321767 68 - 3.254 3.253 -0.006
ENSG00000013306 E025 23.384877 9.138185e-04 1.270296e-12 3.063701e-11 17 44321768 44321828 61 - 1.640 1.120 -1.809
ENSG00000013306 E026 1182.780277 1.784506e-04 3.650919e-01 5.094243e-01 17 44322419 44322421 3 - 2.978 2.967 -0.037
ENSG00000013306 E027 1522.996443 8.477856e-05 2.193416e-01 3.495807e-01 17 44322422 44322438 17 - 3.089 3.076 -0.043
ENSG00000013306 E028 1879.182489 1.352609e-04 3.748816e-01 5.193249e-01 17 44322439 44322472 34 - 3.161 3.173 0.039
ENSG00000013306 E029 1968.443551 2.139804e-04 5.649455e-01 6.921533e-01 17 44322473 44322526 54 - 3.183 3.192 0.030
ENSG00000013306 E030 1057.988713 8.500197e-04 7.789482e-01 8.577970e-01 17 44322527 44322528 2 - 2.923 2.921 -0.006
ENSG00000013306 E031 263.855433 1.755948e-04 4.152395e-03 1.357057e-02 17 44322529 44322552 24 - 2.378 2.304 -0.249
ENSG00000013306 E032 55.666875 4.192910e-04 2.301963e-49 1.341846e-46 17 44322553 44322807 255 - 2.100 1.395 -2.391
ENSG00000013306 E033 1589.838104 1.970558e-03 1.780445e-01 2.986912e-01 17 44322808 44322852 45 - 3.120 3.094 -0.087
ENSG00000013306 E034 1728.094618 2.587070e-03 8.076410e-02 1.607396e-01 17 44323284 44323343 60 - 3.168 3.128 -0.133
ENSG00000013306 E035 1560.393769 5.005836e-03 3.428760e-02 8.030846e-02 17 44323478 44323550 73 - 3.147 3.078 -0.228
ENSG00000013306 E036 977.918974 1.155141e-02 2.216746e-02 5.602298e-02 17 44323551 44323577 27 - 2.977 2.865 -0.372
ENSG00000013306 E037 73.893030 3.348564e-04 1.549135e-20 1.056060e-18 17 44323578 44323590 13 - 2.061 1.657 -1.361
ENSG00000013306 E038 89.914031 4.468635e-03 4.091029e-34 9.405743e-32 17 44323591 44323719 129 - 2.256 1.655 -2.019
ENSG00000013306 E039 62.864202 2.320524e-03 9.356103e-38 2.814064e-35 17 44323720 44323800 81 - 2.122 1.482 -2.165
ENSG00000013306 E040 110.934542 3.577206e-03 3.955278e-46 1.946274e-43 17 44323801 44324129 329 - 2.364 1.731 -2.121
ENSG00000013306 E041 63.235071 3.528102e-03 1.584992e-32 3.210439e-30 17 44324130 44324199 70 - 2.117 1.493 -2.109
ENSG00000013306 E042 50.891242 4.144574e-03 4.344513e-33 9.134905e-31 17 44324248 44324298 51 - 2.057 1.364 -2.351
ENSG00000013306 E043 99.457776 1.175873e-02 5.995608e-25 6.539147e-23 17 44324299 44324710 412 - 2.327 1.669 -2.211
ENSG00000013306 E044 918.129830 8.812406e-03 3.677529e-02 8.503978e-02 17 44324711 44324870 160 - 2.932 2.843 -0.296